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Acute Cycling on Executive Control (ACE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT03499977
Recruitment Status : Not yet recruiting
First Posted : April 17, 2018
Last Update Posted : June 21, 2018
Information provided by (Responsible Party):
Dr. Harry Prapavessis, Western University, Canada

Brief Summary:
This study will examine whether 10-minute bouts of cycling at various intensities will impact executive functioning (i.e., cognitive ability) as assessed by the antisaccade (AS) task through a total of five visits. An antisaccade is a rapid eye movement away from a visual target. The ability to suppress making an eye movement towards a visual target gauges inhibitory control (i.e., a domain of executive functioning). In the initial visit, participants' exercise capacity will be assessed through a maximal effort cycling test. Intensities for the cycling bouts (i.e., high, moderate, low) in subsequent sessions will be based upon this maximal effort cycling test. In visits 2 through 5, participants will complete an AS task, followed by a 10-minute bout of cycling, and then complete the AS task again. The order of cycling intensities will be randomized between participants. Differences in the AS task (i.e., reaction time and accuracy) will be compared between and within cycling conditions.

Condition or disease Intervention/treatment Phase
Physical Activity Behavioral: Sitting Behavioral: Light-Intensity Cycling Behavioral: Moderate-Intensity Cycling Behavioral: High-Intensity Cycling Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Effects of Acute Cycling on Executive Control
Estimated Study Start Date : July 1, 2018
Estimated Primary Completion Date : December 31, 2018
Estimated Study Completion Date : July 31, 2019

Arm Intervention/treatment
Experimental: Sitting
The participant will be asked to sit for 10 min (not increasing their heart rate) then do the anti-saccade task
Behavioral: Sitting
10 min bouts

Experimental: Low-Intensity Cycling
Participant will be asked to cycle for 10 min (<40% VO2R) and then perform the anti-saccade task
Behavioral: Light-Intensity Cycling
10min bout

Experimental: Moderate-Intensity Cycling
The participant will be asked to do 10 min of cycling (40-59% VO2R) followed but the anti-saccade task
Behavioral: Moderate-Intensity Cycling
10 min bout

Experimental: High-Intensity Cycling
The participant will be asked to do 10 min of cycling (60%-84% VO2R) followed but the anti-saccade task
Behavioral: High-Intensity Cycling
10 min bout

Primary Outcome Measures :
  1. Reaction Time [ Time Frame: 30 minutes ]
    Time in milliseconds to target

  2. Accuracy [ Time Frame: 30 minutes ]
    Directional errors

Other Outcome Measures:
  1. Heart Rate [ Time Frame: 10 minutes ]
    Heart rate measured in beats per minute with a Polar Heart Rate Monitor as a manipulation check

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Able to read, write and understand English
  • Full time student enrolled at Western University
  • Able to perform a ten-minute exercise task at a light intensity without health implications
  • Have email or phone number for contacting purposes

Exclusion Criteria:

  • Do not have a medical condition that prevents you from exercise (e.g. heart attack in the past year, heart disease, irregular heartbeat, etc.)
  • Do not have history of eye injury or neurological impairment
  • Do not have an orthopaedic limitation
  • Are not pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03499977

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Contact: Harry Prapavessis, Ph.D 5196612111 ext 80173
Contact: Kirsten B Dillon, B.Sc 6043566359

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Canada, Ontario
Western University
London, Ontario, Canada, N6A3K7
Contact: Harry Prapavessis, Ph.D         
Sponsors and Collaborators
Western University, Canada
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Principal Investigator: Harry Prapavessis, Ph.D Western University

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Responsible Party: Dr. Harry Prapavessis, Principal Investigator, Western University, Canada Identifier: NCT03499977    
Other Study ID Numbers: PA and Executive Functioning
First Posted: April 17, 2018    Key Record Dates
Last Update Posted: June 21, 2018
Last Verified: June 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Dr. Harry Prapavessis, Western University, Canada:
Physical Activity
Executive function