A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (IMpassion030)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT03498716 |
Recruitment Status :
Recruiting
First Posted : April 17, 2018
Last Update Posted : May 22, 2023
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Triple Negative Breast Cancer | Drug: Atezolizumab Drug: Paclitaxel Drug: Dose-dense Doxorubicin or dose-dense Epirubicin Drug: Cyclophosphamide | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 2300 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti PD-L1 Antibody) in Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone in Patients With Operable Triple Negative Breast Cancer |
Actual Study Start Date : | August 2, 2018 |
Estimated Primary Completion Date : | August 2, 2023 |
Estimated Study Completion Date : | August 24, 2025 |

Arm | Intervention/treatment |
---|---|
Experimental: Atezolizumab + Chemotherapy
Participants will receive atezolizumab (in combination with chemotherapy as described below) every 2 weeks for 10 doses, followed by atezolizumab maintenance therapy every 3 weeks to complete 1 year of treatment from the first dose Chemotherapy will consist of paclitaxel every week for 12 weeks, followed by dose-dense doxorubicin +cyclophosphamide or dose-dense epirubicin + cyclophosphamide every 2 weeks, for 4 doses supported with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) |
Drug: Atezolizumab
Atezolizumab will be administered by IV, 840 mg every 2 weeks, for 10 doses. Atezolizumab maintenance will be administered by IV, 1200 mg every 3 weeks to complete 1 year Drug: Paclitaxel Paclitaxel will be administered by IV, 80 mg/m^2 every week for 12 weeks. Drug: Dose-dense Doxorubicin or dose-dense Epirubicin Dose-dense doxorubicin will be administered by IV, 60 mg/m^2 every 2 weeks for a total of 4 doses. Or Dose-dense epirubicin will be administered by IV, (90 mg/m^2) every 2 weeks for a total of 4 doses Drug: Cyclophosphamide Cyclophosphamide will be administered by IV, 600 mg/m^2 every 2 weeks for 4 doses |
Active Comparator: Chemotherapy
Chemotherapy will consist of paclitaxel every week for 12 weeks, followed by dose-dense doxorubicin +cyclophosphamide or dose-dense epirubicin + cyclophosphamide every 2 weeks, for 4 doses supported with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)
|
Drug: Paclitaxel
Paclitaxel will be administered by IV, 80 mg/m^2 every week for 12 weeks. Drug: Dose-dense Doxorubicin or dose-dense Epirubicin Dose-dense doxorubicin will be administered by IV, 60 mg/m^2 every 2 weeks for a total of 4 doses. Or Dose-dense epirubicin will be administered by IV, (90 mg/m^2) every 2 weeks for a total of 4 doses Drug: Cyclophosphamide Cyclophosphamide will be administered by IV, 600 mg/m^2 every 2 weeks for 4 doses |
- Invasive Disease-Free Survival (iDFS) [ Time Frame: Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years). ]
iDFS events are defined as follows:
- Ipsilateral invasive breast tumor recurrence
- Ipsilateral local-regional invasive breast cancer recurrence
- Ipsilateral second primary invasive breast cancer
- Contralateral invasive breast cancer
- Distant recurrence
- Death attributable to any cause
- Overall Survival (OS) [ Time Frame: Randomization to death from any cause through the end of study (approximately 7 years) ]
- Disease-Free Survival (DFS) [ Time Frame: Randomization until the first occurrence of an DFS event, through the end of study (approximately 7 years) ]DFS is defined as any event of the primary endpoint and new diagnosis of an ipsilateral or contralateral non-invasive breast cancer.
- Recurrence-Free Interval (RFI) [ Time Frame: Randomization until local, regional, or distant disease recurrence of breast cancer, through the end of study (approximately 7 years) ]
- Distant RFI [ Time Frame: Randomization until distant disease recurrence, through the end of study (approximately 7 years) ]
- Percentage of participants with adverse events [ Time Frame: Baseline to end of study (approximately 7 years) ]Safety Objective
- Serum concentration of Atezolizumab [ Time Frame: Pre-infusion (0 hour), 30 minutes post-infusion on Week 1 Day 1 (infusion length = 60 minutes); pre-infusion on Day 1 of Weeks 5, 9, 13, 21, 33 and 45; at treatment discontinuation (up to approximately 1 year), 120 days after last dose ]
- Invasive Disease-Free Survival (iDFS) in PDL1- Selected Patients [ Time Frame: Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years) ]
- Invasive Disease-Free Survival (iDFS) in Node- Positive Disease [ Time Frame: Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years) ]
- Invasive Disease Free Survival (iDFS) including second primary non-breast invasive cancer [ Time Frame: Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years) ]
- Percentage of Participants with Anti-Drug Antibodies (ADAs) to Atezolizumab [ Time Frame: Updated: Pre-infusion (0 hour) on Day 1 of Weeks 1, 5, 9, 13, 21, 33 and 45; at treatment discontinuation (up to Week 51), 120 days after last dose ]
- Mean changes from baseline in patient-reported function (role, physical) [ Time Frame: Baseline, Cycle 4 Day 1, Day 1 of every other cycle until Cycle 16 (cycle = 21 days), at the end of treatment/discontinuation visit ((up to approximately 1 year), and during Study Follow-up (up to approximately 7 years). ]Mean changes from baseline score in role, physical function will be assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire - Core 30 (EORTC QLQ-C30)
- Mean changes from baseline in patient-reported health-related quality of life (HRQoL) [ Time Frame: Time Frame: Baseline, Cycle 4 Day 1, Day 1 of every other cycle until Cycle 16 (cycle = 21 days), at the end of treatment/discontinuation visit (up to approximately 1 year), and during Study Follow-up (up to approximately 7 years). ]Mean changes from baseline score in HRQoL will be assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire - Core 30 (EORTC QLQ-C30).

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Non-metastatic operable Stage II-III breast cancer
- Histologically documented TNBC (Triple Negative Breast Cancer)
- Confirmed tumor PD-L1 evaluation as documented through central testing of a representative tumor tissue specimen
- Adequately excised: Patients must have undergone either breast-conserving surgery or mastectomy/nipple- or skin-sparing mastectomy
- Adequate hematologic and end-organ function
- For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures
- For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures and agreement to refrain from donating sperm.
- No more than 8 weeks (56 days) may elapse between definitive breast surgery and randomization.
- Representative formalin-fixed, paraffin embedded (FFPE) tumor specimen from surgical resection in paraffin blocks (preferred) or at least 25 unstained slides.
Exclusion Criteria
- Prior history of invasive breast cancer
- For the currently diagnosed breast cancer, any previous systemic anti-cancer treatment (e.g., neoadjuvant or adjuvant), including, but not limited to, chemotherapy, anti-HER2 therapy.
- Previous therapy with anthracyclines or taxanes for any malignancy
- Cardiopulmonary dysfunction
- Prior malignancies within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death and treated with expected curative outcome
- Active or history of autoimmune disease or immune deficiency
- History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan
- Urinary outflow obstruction
- Active tuberculosis
- Major surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment or anticipation of need for a major surgical procedure during study treatment or within 5 months following the last dose of Atezolizumab (for patients randomized to Atezolizumab)
- Prior allogeneic stem cell or solid organ transplant
- Treatment with systemic immunosuppressive medications within 2 weeks prior to initiation of study treatment or anticipation of need for systemic immunosuppressive medication during the study

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03498716
Contact: Reference Study ID Number: WO39391 https://forpatients.roche.com/ | 888-662-6728 (U.S. and Canada) | global-roche-genentech-trials@gene.com |


United States, California | |
John Muir Health Clinical Research Center | Completed |
Concord, California, United States, 94520 | |
Cedars-Sinai Medical Center | Completed |
Los Angeles, California, United States, 90048 | |
Martin-O?Neil Cancer Center | Completed |
Saint Helena, California, United States, 94574 | |
United States, Florida | |
Baptist - MD Anderson Cancer Center | Completed |
Jacksonville, Florida, United States, 32207 | |
United States, Georgia | |
Northwest Georgia Oncology Centers PC - Marietta | Withdrawn |
Marietta, Georgia, United States, 30060 | |
United States, Illinois | |
Advocate Illinois Masonic Outpatient Center for Advanced Care | Completed |
Chicago, Illinois, United States, 60657 | |
United States, Iowa | |
Des Moines Oncology Research Association | Completed |
Des Moines, Iowa, United States, 50309 | |
United States, Kansas | |
Cancer Center of Kansas | Completed |
Wichita, Kansas, United States, 67214-3728 | |
United States, Louisiana | |
Christus Cabrini Cancer Center | Withdrawn |
Alexandria, Louisiana, United States, 71301 | |
United States, Maryland | |
University of Maryland Greenebaum Comprehensive Cancer Center | Completed |
Baltimore, Maryland, United States, 21201 | |
Mercy Medical Center | Active, not recruiting |
Baltimore, Maryland, United States, 21202 | |
University of Maryland; St. Joseph Medical Center | Withdrawn |
Towson, Maryland, United States, 21204 | |
United States, Minnesota | |
Fairview Southdale Medical Oncology Clinic | Completed |
Edina, Minnesota, United States, 55435 | |
United States, Missouri | |
Mercy Cancer Center - Joplin | Withdrawn |
Joplin, Missouri, United States, 64804 | |
HCA Midwest Division | Completed |
Kansas City, Missouri, United States, 64132 | |
United States, Montana | |
MT Cancer Consortium | Withdrawn |
Billings, Montana, United States, 59101 | |
United States, New Hampshire | |
New Hampshire Hematology Oncology | Recruiting |
Manchester, New Hampshire, United States, 03103 | |
United States, New Jersey | |
The Valley Hospital | Withdrawn |
Paramus, New Jersey, United States, 07652 | |
United States, New York | |
Monter Cancer Center | Active, not recruiting |
Lake Success, New York, United States, 11042 | |
Memorial Sloan Kettering Cancer Center | Completed |
New York, New York, United States, 11101 | |
Rochester General Hospital; Lipson Cancer and Blood Center | Completed |
Rochester, New York, United States, 14621 | |
United States, North Carolina | |
Southeastern Medical Oncology Center - Goldsboro | Withdrawn |
Goldsboro, North Carolina, United States, 27534 | |
United States, Pennsylvania | |
Lancaster General Hospital | Withdrawn |
Lancaster, Pennsylvania, United States, 17604 | |
United States, South Dakota | |
Monument Health Rapid City Hospital, Inc. | Withdrawn |
Rapid City, South Dakota, United States, 57701 | |
United States, Tennessee | |
SCRI | Recruiting |
Nashville, Tennessee, United States, 37203 | |
Vanderbilt University Medical Center | Withdrawn |
Nashville, Tennessee, United States, 37204 | |
United States, Texas | |
The Center for Cancer and Blood Disorders - Fort Worth | Withdrawn |
Fort Worth, Texas, United States, 76104 | |
United States, Utah | |
Intermountain Medical Center | Withdrawn |
Murray, Utah, United States, 84107 | |
Intermountain Precision Genomics Cancer Research Clinic-Dixie | Completed |
Saint George, Utah, United States, 84770 | |
United States, West Virginia | |
St. Mary's Medical Center | Completed |
Huntington, West Virginia, United States, 25702 | |
Argentina | |
Centro de Oncologia e; Investigacion Buenos Aires - COIBA | Active, not recruiting |
Berazategui, Argentina, B1880BBF | |
INSTITUTO DE INVESTIGACIONES METABOLICAS (IDIM); Oncology | Completed |
Ciudad Autonoma Buenos Aires, Argentina, C1012AAR | |
Hospital Britanico de Buenos Aires | Completed |
Ciudad Autonoma Buenos Aires, Argentina, C1284AEB | |
Clinica Universitaria Reina Fabiola | Completed |
Cordoba, Argentina, X5004FHP | |
Fundación Ars Medica | Recruiting |
Jujuy, Argentina | |
Centro Oncologico Riojano Integral (CORI) | Completed |
La Rioja, Argentina, F5300COE | |
Centro de Investigacion Pergamino SA | Recruiting |
Pergamino, Argentina, B2700CPM | |
Instituto de Oncología de Rosario | Completed |
Rosario, Argentina, S2000KZE | |
Centro Medico San Roque | Completed |
San Miguel de Tucuman, Argentina, T4000IAK | |
Centro de Investigacion Clinica - Clinica Viedma S.A.; Oncology Department | Completed |
Viedma, Argentina, R8500ACE | |
Australia, New South Wales | |
Bankstown-Lidcombe Hospital | Completed |
Bankstown, New South Wales, Australia, 2200 | |
Chris O'Brien Lifehouse | Recruiting |
Camperdown, New South Wales, Australia, 2050 | |
St Vincent's Hospital Sydney | Completed |
Darlinghurst, New South Wales, Australia, 2010 | |
Lismore Base Hospital | Completed |
Lismore, New South Wales, Australia, 2480 | |
Macquarie University Hospital | Completed |
Macquarie Park, New South Wales, Australia, 2109 | |
Northern Cancer Institute | Withdrawn |
St Leonards, New South Wales, Australia, 2065 | |
Tweed Hospital | Completed |
Tweed Heads, New South Wales, Australia, 2485 | |
Sydney Adventist Hospital | Completed |
Wahroonga, New South Wales, Australia, 2076 | |
Australia, Queensland | |
Icon Cancer Care Wesley | Completed |
Auchenflower, Queensland, Australia, 4066 | |
Icon Cancer Foundation; Icon Cancer Care Chermside | Active, not recruiting |
Chermside, Queensland, Australia, 4032 | |
Icon Cancer Care South Brisbane | Active, not recruiting |
South Brisbane, Queensland, Australia, 4101 | |
Icon Cancer Foundation | Withdrawn |
South Brisbane, Queensland, Australia, 4101 | |
Mater Hospital; Cancer Services | Completed |
South Brisbane, Queensland, Australia, 4101 | |
Icon Cancer Foundation; Icon Cancer Care Southport | Active, not recruiting |
Southport, Queensland, Australia, 4215 | |
Princess Alexandra Hospital; Cancer Trials Unit | Completed |
Woolloongabba, Queensland, Australia, 4102 | |
Australia, South Australia | |
Royal Adelaide Hospital; Cancer Centre | Completed |
Adelaide, South Australia, Australia, 5000 | |
Ashford Cancer Center Research | Completed |
Kurralta Park, South Australia, Australia, 5037 | |
Australia, Victoria | |
Box Hill Hospital; Eastern Clinical Research Unit | Active, not recruiting |
Box Hill, Victoria, Australia, 3128 | |
Monash Medical Centre | Completed |
Clayton, Victoria, Australia, 3168 | |
Peninsula and South Eastern Haematology and Oncology Group | Withdrawn |
Frankston, Victoria, Australia, 3199 | |
Austin Hospital Olivia Newton John Cancer Centre | Completed |
Heidelberg, Victoria, Australia, 3084 | |
Maroondah Hospital; Breast Clinic | Recruiting |
Ringwood East, Victoria, Australia, 3135 | |
Austria | |
Lkh-Univ. Klinikum Graz; Klinik Für Gynäkologie | Active, not recruiting |
Graz, Austria, 8036 | |
Medical University Innsbruck; Frauenklinik Innsbruck, Dept Gyn | Active, not recruiting |
Innsbruck, Austria, 6020 | |
Ordensklinikum Linz Barmherzige Schwestern; Interne 1 - Hämato-Onkologie | Active, not recruiting |
Linz, Austria, 4010 | |
Uniklinikum Salzburg, LKH; Univ.Klinik f. Innere Medizin III der PMU | Active, not recruiting |
Salzburg, Austria, 5020 | |
AKH - Medizinische Universität Wien; Department of Oncology | Active, not recruiting |
Vienna, Austria, 1090 | |
General Hospital Hietzing, KLI; Dept. Obstet&Gynecol | Active, not recruiting |
Vienna, Austria, 1130 | |
Salzkammergut-Klinikum Voecklabruck | Active, not recruiting |
Vöcklabruck, Austria, 4840 | |
Klinikum Kreuzschwestern Wels; Iv. Interne Abt. | Active, not recruiting |
Wels, Austria, 4600 | |
Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie | Recruiting |
Wien, Austria, 1090 | |
Belgium | |
AZ KLINA | Completed |
Brasschaat, Belgium, 2930 | |
Institut Jules Bordet | Completed |
Bruxelles, Belgium, 1000 | |
UZ Leuven Gasthuisberg | Completed |
Leuven, Belgium, 3000 | |
CHC MontLégia | Completed |
Liege, Belgium, 4000 | |
Chr de La Citadelle | Completed |
Liège, Belgium, 4000 | |
CHU de Liège | Withdrawn |
Liège, Belgium, 4000 | |
CHU Ambroise Paré | Completed |
Mons, Belgium, 7000 | |
Clinique Sainte-Elisabeth; Oncologie | Completed |
Namur, Belgium, 5000 | |
Vitaz | Completed |
Sint Niklaas, Belgium, 9100 | |
Brazil | |
Nucleo de Oncologia da Bahia - NOB | Completed |
Salvador, Bahia, BA, Brazil, 40170-380 | |
Nucleo de Oncologia da Bahia - NOB | Withdrawn |
Salvador, Bahia, BA, Brazil, 40170-380 | |
Crio - Centro Regional Integrado de Oncologia | Completed |
Fortaleza, CE, Brazil, 60336-232 | |
Instituto Nacional de Cancer - INCa; Oncologia | Completed |
Rio de Janeiro, RJ, Brazil, 20560-120 | |
Hospital Jardim Amália | Completed |
Volta Redonda, RJ, Brazil, 27251-260 | |
Universidade de Caxias do Sul - Rio Grande do Sul | Recruiting |
Caxias do Sul, RS, Brazil, 95070-560 | |
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda | Recruiting |
Ijui, RS, Brazil, 98700-000 | |
Hospital Moinhos de Vento | Completed |
Porto Alegre, RS, Brazil, 90035-000 | |
Hospital das Clinicas - UFRGS | Completed |
Porto Alegre, RS, Brazil, 90035-903 | |
Hospital Mae de Deus | Completed |
Porto Alegre, RS, Brazil, 90110-000 | |
Hospital Sao Lucas - PUCRS | Recruiting |
Porto Alegre, RS, Brazil, 90610-000 | |
Clinica de Neoplasias Litoral | Completed |
Itajai, SC, Brazil, 88301-220 | |
Hospital de Cancer de Barretos | Completed |
Barretos, SP, Brazil, 14784-400 | |
Hospital Amaral Carvalho | Completed |
Jau, SP, Brazil, 17210-120 | |
Faculdade de Medicina do ABC - FMABC | Completed |
Santo Andre, SP, Brazil, 09060-650 | |
Hospital Sírio-Libanês | Withdrawn |
Sao Paulo, SP, Brazil, 01308-050 | |
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda | Completed |
Sao Paulo, SP, Brazil, 01317-001 | |
Instituto Brasileiro de Controle Do Câncer ? São Camilo Oncologia | Recruiting |
Sao Paulo, SP, Brazil, 04014-002 | |
Instituto Do Câncer Do Estado de São Paulo Octávio Frias de Oliveira | Completed |
São Paulo, SP, Brazil, 01246 000 | |
China | |
The 307th Hospital of Chinese People?s Liberation Army | Recruiting |
Beijing City, China, 100071 | |
Peking University People's Hospital | Completed |
Beijing, China, 100044 | |
Beijing Hospital; Internal Medicine-Oncology | Completed |
Beijing, China, 100730 | |
Beijing Union Hospital | Completed |
Beijing, China, 100730 | |
The First Hospital of Jilin University | Completed |
Changchun City, China, 130021 | |
Jilin Cancer Hospital | Completed |
Changchun, China, 132013 | |
West China Hospital, Sichuan University | Completed |
Chengdu, China, 610041 | |
Chongqing Cancer Hospital | Completed |
Chongqing, China, 400030 | |
Fujian Medical University Union Hospital | Completed |
Fuzhou City, China, 350001 | |
The 900th Hospital of PLA joint service support force | Recruiting |
Fuzhou, China, 110016 | |
Sun yat-sen University Cancer Center; Internal Medicine of Oncology | Completed |
Guangzhou, China, 510060 | |
Guangdong General Hospital | Completed |
Guangzhou, China, 510080 | |
Sun Yat-Sen University Cancer Center - Huangpu Campus | Completed |
Guangzhou, China | |
The First Affiliated Hospital of College of Medicine, Zhejiang University | Completed |
Hangzhou, China, 310003 | |
The Second Affiliated Hospital of Zhejiang University College | Completed |
Hangzhou, China, 310009 | |
Harbin Medical University Cancer Hospital | Completed |
Harbin, China, 150081 | |
Shandong Cancer Hospital | Completed |
Jinan, China, 250117 | |
Luoyang Central Hospital | Completed |
Luoyang City, China, 471000 | |
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School | Completed |
Nanjing City, China, 210008 | |
Jiangsu Province Hospital | Withdrawn |
Nanjing, China, 210008 | |
The Affiliated Hospital of Medical College Qingdao University | Recruiting |
Qingdao, China, 266003 | |
Fudan University Shanghai Cancer Center | Completed |
Shanghai City, China, 200120 | |
Shanghai Jiao Tong University School of Medicine (SJTUSM) - Ruijin Hospital (GuangCi Hospital) | Recruiting |
Shanghai, China, 200025 | |
Zhongshan Hospital Fudan University | Completed |
Shanghai, China, 200032 | |
Changhai Hospital of Shanghai | Withdrawn |
Shanghai, China, 200433 | |
The University of Hong Kong-Shenzhen Hospital | Completed |
Shenzhen City, China, 518053 | |
Hebei Medical University Fourth Hospital;(Tumor Hospital of Hebei Province) | Completed |
Shijiazhuang, China, 050035 | |
Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology | Completed |
Wuhan City, China, 430022 | |
Hubei Cancer Hospital | Completed |
Wuhan, China, 430079 | |
The First Affiliated Hospital of Xian Jiao Tong University | Completed |
Xi'an City, China, 710061 | |
Zhejiang Cancer Hospital | Completed |
Zhejiang, China, 310022 | |
Henan Cancer Hospital | Recruiting |
Zhengzhou, China, 450008 | |
Czechia | |
Nemocnice Horovice, NH Hospital a.s.; Oncology Department | Completed |
Horovice, Czechia, 26831 | |
Fakultni nemocnice Hradec Kralove | Withdrawn |
Hradec Kralove, Czechia, 500 05 | |
Fakultni nemocnice Olomouc; Onkologicka klinika | Completed |
Olomouc, Czechia, 779 00 | |
Fakultni Nemocnice V Motole, S.P. | Withdrawn |
Prague, Czechia, 15060 | |
Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika | Completed |
Praha 2, Czechia, 128 08 | |
Krajska nemocnice T. Bati, a.s. | Completed |
Zlin, Czechia, 76001 | |
Denmark | |
Herlev Hospital; Afdeling for Kræftbehandling | Completed |
Herlev, Denmark, 2730 | |
Sjællands Universitetshospital, Næstved; Onkologisk Afdeling | Withdrawn |
Naestved, Denmark, 4700 | |
Odense Universitetshospital, Onkologisk Afdeling, Klinisk Forsknings Enhed | Completed |
Odense C, Denmark, 5000 | |
Sygehus Lillebælt, Vejle | Completed |
Vejle, Denmark, 7100 | |
France | |
Centre Hospitalier Regional Metz-Thionville - Hopital de Mercy | Completed |
Ars-Laquenexy, France, 57530 | |
Institut Sainte Catherine | Completed |
Avignon, France, 84082 | |
CH de Beauvais | Completed |
Beauvais, France, 60000 | |
CHU Jean Minjoz | Completed |
Besançon, France, 25030 | |
Centre Hospitalier De Blois | Withdrawn |
Blois, France, 41016 | |
Clinique Tivoli; Sce Radiotherapie | Completed |
Bordeaux, France, 33000 | |
Institut Bergonie | Withdrawn |
Bordeaux, France, 33076 | |
Polyclinique Bordeaux Nord Aquitaine | Completed |
Bordeaux, France, 33300 | |
Centre Hospitalier Fleyriat | Completed |
Bourg-en- Bresse Cedex, France, 01012 | |
CHRU De Brest - Hopital Morvan - Institut De Cancerologie Et D'Hematologie | Completed |
Brest, France, 29609 | |
CRLCC-Francois Baclesse; Oncologie Médicale | Completed |
Caen, France, 14076 | |
CH de Cholet; oncologie | Completed |
Cholet, France, 49325 | |
Centre Jean Perrin | Recruiting |
Clermont Ferrand, France, 63011 | |
Centre Hospitalier de Compiegne | Completed |
Compiegne, France, 60321 | |
Centre Hospitalier Alpes Leman | Completed |
Contamine Sur Arve, France, 74130 | |
Centre Georges Francois Leclerc | Completed |
Dijon, France, 21000 | |
CHU de Grenoble - Hôpital André Michallon | Active, not recruiting |
Grenoble Cedex 9, France, 38043 | |
Centre Hospitalier Departemental de Vendee | Completed |
La Roche Sur Yon, France, 85925 | |
Centre Hospitalier De Versailles | Withdrawn |
Le Chesnay, France, 78157 | |
Clinique des Ormeaux; Oncologie | Withdrawn |
Le Havre, France, 76600 | |
Hôpital Privé de l'Estuaire | Withdrawn |
Le Havre, France, 76620 | |
Clinique Chenieux; Oncology | Completed |
Limoges, France, 87039 | |
Centre Hospitalier Bretagne Sud | Completed |
Lorient, France, 56100 | |
Centre Leon Berard | Withdrawn |
Lyon, France, 69008 | |
Hopital Prive Jean Mermoz | Completed |
Lyon, France, 69008 | |
Hopital Europeen | Withdrawn |
Marseille, France, 13003 | |
Hôpital Saint Joseph | Completed |
Marseille, France, 13008 | |
Institut Paoli Calmettes | Withdrawn |
Marseille, France, 13009 | |
Centre Hospitalier de Mont de Marsan - Hopital Layne | Withdrawn |
Mont De Marsan, France, 40024 | |
Clinique Clémentville | Completed |
Montpellier, France, 34070 | |
Institut régional du Cancer Montpellier | Completed |
Montpellier, France, 34298 | |
l'Hôpital privé du Confluent SAS | Completed |
Nantes, France, 44202 | |
Centre Antoine Lacassagne | Completed |
Nice, France, 06189 | |
CHR Orleans, Hopital Madeleine | Withdrawn |
Orléans, France, 45067 | |
Institut Curie | Withdrawn |
Paris, France, 75005 | |
Polyclinique Francheville | Withdrawn |
Perigueux, France, 24004 | |
Centre Armoricain de Radiotherapie, de Imagerie Medicale et de Oncologie (CARIO) | Withdrawn |
Plerin, France, 22190 | |
CH Annecy Genevois site Annecy; Oncologie | Completed |
Pringy, France, 74374 | |
Chi De Cornouaille; Oncologie Hospitalisation | Completed |
Quimper, France, 29107 | |
Institut Jean Godinot | Completed |
Reims, France, 51056 | |
Institut du Cancer Coulancy Reims | Completed |
Reims, France, 51100 | |
Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer | Withdrawn |
Rennes, France, 35000 | |
Centre Henri Becquerel | Completed |
Rouen, France, 76038 | |
Institut De Cancerologie Lucien Newrth | Completed |
St Priest en Jarez CEDEX, France, 42271 | |
Centre Paul Strauss | Completed |
Strasbourg, France, 67000 | |
Hopitaux Du Leman - Site Georges Pianta | Completed |
Thonon Les Bains, France, 74200 | |
Institut Claudius Régaud | Completed |
Toulouse, France, 31059 | |
Clinique Pasteur | Withdrawn |
Toulouse, France, 31076 | |
Clinique Pasteur; Imagerie Medicale | Withdrawn |
Toulouse, France, 31300 | |
CHU Tours - Hôpital Bretonneau | Completed |
Tours, France, 37044 | |
Hopital Prive Drome Ardeche; Hopital De Jour | Completed |
Valence, France, 26000 | |
Institut de Cancérologie de Lorraine | Completed |
Vandoeuvre-Les-Nancy, France, 54519 | |
Institut Gustave Roussy; Departement Oncologie Medicale | Completed |
Villejuif, France, 94805 | |
Hopital Prive Villeneuve d Ascq;Chimiotherapie Radiotherapie | Withdrawn |
Villeneuve D Ascq, France, 59657 | |
Germany | |
Praxisklinik Krebsheilkunde für Frauen / Brustzentrum (Dres. Kittel/Klare) | Withdrawn |
Berlin, Germany, 10367 | |
Studienzentrum Berlin City | Completed |
Berlin, Germany, 14169 | |
Hämato-Onkologie im Medicum/Home | Withdrawn |
Bremen, Germany, 28209 | |
St. Johannes-Hospital | Recruiting |
Dortmund, Germany, 44137 | |
Onkozentrum Dres. Göhler | Recruiting |
Dresden, Germany, 01127 | |
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie | Recruiting |
Dresden, Germany, 01307 | |
Praxis für Hamatologie und Onkologie | Recruiting |
Erfurt, Germany, 99085 | |
Klinikum Frankfurt Höchst GmbH | Withdrawn |
Frankfurt, Germany, 65929 | |
Onkodok GmbH | Active, not recruiting |
Gütersloh, Germany, 33332 | |
Albertinen-Krankenhaus Klinik f.Gynäkologie und Geburtshilfe | Recruiting |
Hamburg, Germany, 22457 | |
Gynäkologisch Onkologische Praxis Hannover | Recruiting |
Hannover, Germany, 30177 | |
Ärztehaus am Bahnhofsplatz; Praxis Uleer/Pourfard | Recruiting |
Hildesheim, Germany, 31134 | |
ViDia Christliche Kliniken Karlsruhe, Vincentius-Diakonissen-Kliniken gAG; Frauenklinik | Recruiting |
Karlsruhe, Germany, 76135 | |
St. Elisabeth-Krankenhaus | Recruiting |
Köln, Germany, 50935 | |
Gemeinschaftspraxis für Onkologie und Hämatologie | Withdrawn |
Langen, Germany, 63225 | |
Klinikum Ludwigsburg; Studiensekretariat | Recruiting |
Ludwigsburg, Germany, 71640 | |
St. Vincenz-Elisabeth-Hospital; Katholisches Klinikum Mainz | Recruiting |
Mainz, Germany, 55131 | |
Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde | Recruiting |
Mainz, Germany, 55131 | |
Universitaets Medizin Mannheim | Withdrawn |
Mannheim, Germany, 68167 | |
Dres. Michael Maasberg Marion Schmitz und Maria Theresia Keller | Completed |
Mayen, Germany, 56727 | |
Klinikum Memmingen; Abt.Gynäkologie | Recruiting |
Memmingen, Germany, 87700 | |
Johannes Wesling Klinikum Minden; Hämatologie, Onkologie, Hämostaseologie und Palliativmedizin | Recruiting |
Minden, Germany, 32429 | |
Brustzentrum Rhein-Ruhr Servicegesellschaft mbH | Recruiting |
Mönchengladbach, Germany, 41061 | |
Klinikum der Universität München; Frauenklinik - Onkologie II | Recruiting |
München, Germany, 80336 | |
Klinikum Neumarkt; Frauenklinik | Recruiting |
Neumarkt i.d.OPf., Germany, 92318 | |
Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe | Completed |
Offenbach, Germany, 63069 | |
Studienzentrum Onkologie Ravensburg GbR; Onkologie Ravensburg | Withdrawn |
Ravensburg, Germany, 88212 | |
Johanniter Frauenklinik Stendal Germany | Recruiting |
Stendal, Germany, 39676 | |
Gynäkologie Kompetenzzentrum; Praxis Dr. med. Carsten Hielscher | Recruiting |
Stralsund, Germany, 18439 | |
Universitätsklinik Tübingen; Frauenklinik | Recruiting |
Tübingen, Germany, 72076 | |
GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe | Active, not recruiting |
Weinheim, Germany, 69469 | |
Marien-Hospital Witten, MVZ Witten | Recruiting |
Witten, Germany, 58452 | |
Klinikum Worms; Frauenklinik; Klinik für Gynäkologie und Geburtshilfe | Recruiting |
Worms, Germany, 67550 | |
Hong Kong | |
Pamela Youde Nethersole Eastern Hospital; Clinical Oncology | Completed |
Hong Kong, Hong Kong | |
Queen Mary Hospital | Completed |
Hong Kong, Hong Kong | |
Queen Elizabeth Hospital Department of Clinical Oncology | Completed |
Kowloon, Hong Kong | |
Hungary | |
Szent Margit Hospital; Dept. of Oncology | Withdrawn |
Budapest, Hungary, 1032 | |
National Institute of Oncology, A Dept of Internal Medicine | Completed |
Budapest, Hungary, 1122 | |
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház | Completed |
Miskolc, Hungary, 3526 | |
Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet | Completed |
Pécs, Hungary, 7623 | |
Ireland | |
Mater Misecordiae University Hospital | Completed |
Dublin, Ireland, 7 | |
Beaumont Hospital; Cancer Clinical Trials Unit | Completed |
Dublin, Ireland, 9 | |
University Hospital Limerick - PIN | Withdrawn |
Limerick, Ireland, V 94 F858 | |
Israel | |
Rambam Health Care Campus; Hematology | Withdrawn |
Haifa, Israel, 31096 | |
Shaare Zedek Medical Center | Completed |
Jerusalem, Israel, 9103102 | |
Hadassah Med Org Kiryat; Oncology Institute | Completed |
Jerusalem, Israel, 9112000 | |
Meir Medical center, Pediatrics | Completed |
Kfar Sava, Israel, 4428164 | |
Rabin MC; Davidof Center - Oncology Institute | Completed |
Petach Tikva, Israel, 4941492 | |
The Chaim Sheba Medical Center | Completed |
Ramat Gan, Israel, 5211401 | |
Kaplan Medical Center | Withdrawn |
Rehovot, Israel, 7610001 | |
Italy | |
Azienda Ospedaliera Papa Giovanni XXIII | Completed |
Bergamo, Abruzzo, Italy, 24060 | |
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica | Active, not recruiting |
Napoli, Campania, Italy, 80131 | |
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S.Orsola Malpighi; UO Farmacia Clinica | Completed |
Bologna, Emilia-Romagna, Italy, 40138 | |
U.O Medicina Oncologica Ospedale di Carpi | Recruiting |
Carpi, Emilia-Romagna, Italy, 41012 | |
Ospedale Degli Infermi - Faenza; Oncologia Medica | Completed |
Faenza, Emilia-Romagna, Italy, 48018 | |
Ospedale Civile; Day Hospital Oncologico | Recruiting |
Guastalla, Emilia-Romagna, Italy, 42016 | |
Azienda Ospedaliero - Universitaria di Modena Policlinico | Completed |
Modena, Emilia-Romagna, Italy, 41110 | |
Azienda Ospedaliero Universitaria di Parma | Completed |
Parma, Emilia-Romagna, Italy, 43126 | |
Ospedale degli Infermi | Completed |
Rimini, Emilia-Romagna, Italy, 47923 | |
Centro Di Riferimento Oncologico; SOC Oncologia Medica C | Withdrawn |
Aviano, Friuli-Venezia Giulia, Italy, 33081 | |
A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia | Completed |
Udine, Friuli-Venezia Giulia, Italy, 33100 | |
Policlinico Universitario Campus Biomedico Di Roma | Completed |
Roma, Lazio, Italy, 00128 | |
Ospedale Belcolle Di Viterbo; Oncologia | Active, not recruiting |
Viterbo, Lazio, Italy, 01100 | |
Ente Ospedaliero Ospedali Galliera | Recruiting |
Genova, Liguria, Italy, 16128 | |
Azienda Ospedaliero Universitaria San Martino | Completed |
Genova, Liguria, Italy, 16132 | |
ASST DI LECCO; Oncologia Medica | Completed |
Lecco, Lombardia, Italy, 23900 | |
Ospedale Mater Salutis | Completed |
Legnago (VR), Lombardia, Italy, 37045 | |
Fondazione IRCCS CA? Granda Ospedale Maggiore Policlinico; U.O.C. di Oncologia Medica | Active, not recruiting |
Milano, Lombardia, Italy, 20122 | |
Istituto Europeo Di Oncologia | Completed |
Milano, Lombardia, Italy, 20141 | |
Fondazione Salvatore Maugeri | Completed |
Pavia, Lombardia, Italy, 27100 | |
Policlinico San Mattea | Completed |
Pavia, Lombardia, Italy, 27100 | |
Istituto Clinico Humanitas | Completed |
Rozzano (MI), Lombardia, Italy, 20089 | |
Ospedale Civile Di Sondrio; Divisione Medicina Generale | Recruiting |
Sondrio, Lombardia, Italy, 23100 | |
Azienda Ospedaliera SS. Antonio E. Biagio E. Cesare Arrigo di Alessandria | Completed |
Alessandria, Piemonte, Italy, 15121 | |
Ospedale Degli Infermi Di Biella; Reparto Oncologia Medica | Completed |
Ponderano (BI), Piemonte, Italy, 13875 | |
Ospedale Santa Maria Annunziata; Oncologia | Completed |
Bagno a Ripoli, Toscana, Italy, 50012 | |
Azienda Usl 7; Dept. Oncologico | Completed |
Poggibonsi, Toscana, Italy, 53036 | |
Nuovo Ospedale Di Prato | Completed |
Prato, Toscana, Italy, 50047 | |
Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia | Completed |
Perugia, Umbria, Italy, 06100 | |
Azienda Ospedaliero Universitaria di Ferrara - U.O. Di Oncologia | Recruiting |
Cona (FE), Veneto, Italy, 44124 | |
Japan | |
Aichi Cancer Center Hospital | Active, not recruiting |
Aichi, Japan, 464-8681 | |
Chiba Cancer Center | Active, not recruiting |
Chiba, Japan, 260-8717 | |
Shikoku Cancer Center | Active, not recruiting |
Ehime, Japan, 791-0280 | |
National Hospital Organization Kyushu Cancer Center | Active, not recruiting |
Fukuoka, Japan, 811-1395 | |
Fukushima Medical University Hospital | Active, not recruiting |
Fukushima, Japan, 960-1295 | |
Hiroshima City Hiroshima Citizens Hospital | Active, not recruiting |
Hiroshima, Japan, 730-8518 | |
National Hospital Organization Hokkaido Cancer Center | Active, not recruiting |
Hokkaido, Japan, 003-0804 | |
Hyogo Medical University Hospital | Active, not recruiting |
Hyogo, Japan, 663-8501 | |
University of Tsukuba Hospital | Active, not recruiting |
Ibaraki, Japan, 305-8576 | |
Sagara Hospital | Active, not recruiting |
Kagoshima, Japan, 892-0833 | |
Kanagawa Cancer Center | Active, not recruiting |
Kanagawa, Japan, 241-8515 | |
Tokai University Hospital | Active, not recruiting |
Kanagawa, Japan, 259-1193 | |
Kumamoto Shinto General Hospital | Withdrawn |
Kumamoto, Japan, 862-8655 | |
Kyoto University Hospital | Active, not recruiting |
Kyoto, Japan, 606-8507 | |
Okayama University Hospital | Active, not recruiting |
Okayama, Japan, 700-8558 | |
Naha-nishi Clinic | Active, not recruiting |
Okinawa, Japan, 901-0154 | |
National Hospital Organization Osaka National Hospital | Active, not recruiting |
Osaka, Japan, 540-0006 | |
Osaka International Cancer Institute | Active, not recruiting |
Osaka, Japan, 541-8567 | |
Saitama Medical University International Medical Center | Active, not recruiting |
Saitama, Japan, 350-1298 | |
Saitama Cancer Center | Active, not recruiting |
Saitama, Japan, 362-0806 | |
Shizuoka Cancer Center | Active, not recruiting |
Shizuoka, Japan, 411-8777 | |
St. Luke's Internat. Hospital, Breast Surgical Oncology | Active, not recruiting |
Tokyo, Japan, 104-8560 | |
The Cancer Institute Hospital of JFCR | Active, not recruiting |
Tokyo, Japan, 135-8550 | |
Korea, Republic of | |
Chungbuk National University Hospital | Completed |
Cheongju-si, Korea, Republic of, 28644 | |
Soon Chun Hyang University Cheonan Hospital | Completed |
Dongnam-gu, Cheonan-si, Korea, Republic of, 31151 | |
National Cancer Center | Completed |
Goyang-si, Korea, Republic of, 10408 | |
Uijeongbu St. Mary's Hospital | Recruiting |
Gyeonggi-do, Korea, Republic of, 11765 | |
CHA Bundang Medical Center | Completed |
Gyeonggi-do, Korea, Republic of, 13496 | |
Gachon University Gil Medical Center | Completed |
Incheon, Korea, Republic of, 21565 | |
Inha University Hospital | Completed |
Incheon, Korea, Republic of, 22332 | |
Seoul National University Bundang Hospital | Completed |
Seongnam-si, Korea, Republic of, 463-707 | |
Seoul National University Hospital | Completed |
Seoul, Korea, Republic of, 03080 | |
Kangbuk Samsung Hospital | Recruiting |
Seoul, Korea, Republic of, 03181 | |
Severance Hospital; Yonsei University Health System | Completed |
Seoul, Korea, Republic of, 03722 | |
Asan Medical Center | Completed |
Seoul, Korea, Republic of, 05505 | |
Gangnam Severance Hospital | Completed |
Seoul, Korea, Republic of, 06273 | |
Seoul St Mary's Hospital | Completed |
Seoul, Korea, Republic of, 06591 | |
Ewha Womans University Hospital (Seoul) | Recruiting |
Seoul, Korea, Republic of, 07804 | |
Ewha Womans University Mokdong Hospital | Completed |
Seoul, Korea, Republic of, 07985 | |
Samsung Medical Center | Completed |
Seoul, Korea, Republic of, 135-710 | |
Ajou University Hospital | Completed |
Suwon City, Korea, Republic of, 443-721 | |
Ulsan University Hosiptal | Completed |
Ulsan, Korea, Republic of, 44033 | |
Wonju Christian Hospital | Completed |
Wonju, Korea, Republic of, 220-701 | |
Mexico | |
Centro de Estudios y Prevencion del Cancer AC | Recruiting |
Tuxtla Gutiérrez, Chiapas, Mexico, 29038 | |
Health Pharma Professional Research | Completed |
Cdmx, Mexico CITY (federal District), Mexico, 03100 | |
Iem-Fucam | Completed |
D.f., Mexico CITY (federal District), Mexico, 04980 | |
Instituto Nacional De Cancerologia; Oncology; Tumores Mamarios | Completed |
Distrito Federal, Mexico CITY (federal District), Mexico, 14000 | |
Centro Médico Zambrano Hellion | Completed |
Monterrey, Nuevo LEON, Mexico, 66278 | |
Centro de Investigacion Clinica de Oaxaca | Completed |
Oaxaca de Juárez, Oaxaca, Mexico, 68020 | |
Oncologico Potosino | Completed |
San Luis Potosí, SAN LUIS Potosi, Mexico, 78209 | |
Clinica Medica Research SC | Recruiting |
Orizaba, Veracruz, Mexico, 94300 | |
Merida | Investigacion Clinica | Completed |
Mérida, Yucatan, Mexico, 97125 | |
Consultorio de Medicina Especializada; Dentro de Condominio San Francisco | Completed |
Mexico City, Mexico, 03100 | |
Centro Medico Dalinde | Completed |
Mexico City, Mexico, 06700 | |
Peru | |
Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud; Oncology & Haemathology | Completed |
Arequipa, Peru, 04001 | |
Oncosalud Sac; Oncología | Completed |
Lima, Peru, 41 | |
Clinica San Felipe | Withdrawn |
Lima, Peru, Lima 11 | |
Instituto Nacional de Enfermedades Neoplasicas | Completed |
Lima, Peru, Lima 34 | |
Poland | |
Instytut MSF Sp. z o.o. | Completed |
?ód?, Poland, 90-302 | |
Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii | Withdrawn |
Gda?sk, Poland, 80-214 | |
Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii | Withdrawn |
Kraków, Poland, 30-688 | |
MedTrials | Withdrawn |
Kraków, Poland, 31-436 | |
Szpital Kliniczny Przemienienia Panskiego Uni. Medycznego im. Karola Marcinkowskiego; Chemotherapy | Withdrawn |
Pozna?, Poland, 60-569 | |
MedPolonia | Completed |
Poznan, Poland, 60-693 | |
Wielkopolskie Centrum Onkologi | Completed |
Poznan, Poland, 61-866 | |
Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy; Klinika Onkologii | Completed |
Warszawa, Poland, 00-909 | |
Romania | |
"Filantropia" Clinical Hospital; Gynecological Oncology | Completed |
Bucharest, Romania, 011191 | |
Institutul Oncologic Prof. Dr. Al. Trestioreanu Bucuresti | Withdrawn |
Bucuresti, Romania, 022328 | |
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca; Oncologie Medicala | Completed |
Cluj Napoca, Romania, 400015 | |
Centrul de Oncologie Sfantul Nectarie | Completed |
Craiova, Romania, 200347 | |
Russian Federation | |
Medsi Clinic | Completed |
Moscow, Adygeja, Russian Federation, 143442 | |
Arkhangelsk Regional Clinical Oncology Dispensary | Completed |
Arkhangelsk, Arhangelsk, Russian Federation, 163045 | |
Bashkirian Republican Clinical Oncology Dispensary | Completed |
UFA, Baskortostan, Russian Federation, 450054 | |
Regional Clinical Oncology Hospital | Completed |
Yaroslavl, Jaroslavl, Russian Federation, 150054 | |
Federal State Institution Medical Radiology Research Center | Recruiting |
Obninsk, Kaluga, Russian Federation, 249036 | |
Oncologica Dispensary #2 | Completed |
Sochi, Krasnodar, Russian Federation, 354057 | |
Evimed | Completed |
Chelyabinsk, Kurgan, Russian Federation | |
City Clinical Hospital #4 | Completed |
Saransk, Mordovija, Russian Federation, 430032 | |
Mordovia State University | Completed |
Saransk, Mordovija, Russian Federation, 430032 | |
Moscow City Oncology Hospital #62 | Withdrawn |
Moscovskaya Oblast, Moskovskaja Oblast, Russian Federation, 143423 | |
Moscow Clinical Scientific Center | Completed |
Moscow, Moskovskaja Oblast, Russian Federation, 111123 | |
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF | Completed |
Moscow, Moskovskaja Oblast, Russian Federation, 115478 | |
Russian Scientific Center of Roentgenoradiology | Withdrawn |
Moscow, Moskovskaja Oblast, Russian Federation, 117997 | |
P.A. Herzen Oncological Inst. ; Oncology | Completed |
Moscow, Moskovskaja Oblast, Russian Federation, 125248 | |
Nizhny Novgorod Regional Clinical Oncology Center | Completed |
Nizhny Novgorod, Niznij Novgorod, Russian Federation, 603126 | |
National Medical Research Center for Oncology | Completed |
Rostov-na-donu, Rostov, Russian Federation, 344037 | |
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological) | Completed |
Saint-Petersburg, Sankt Petersburg, Russian Federation, 197758 | |
FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov" | Completed |
Saint-Petersburg, Sankt Petersburg, Russian Federation | |
LLC Strategic Medical Systems | Completed |
Sankt-peterburg, Sankt Petersburg, Russian Federation, 194291 | |
EosMed LLC | Completed |
Sankt-peterburg, Sankt Petersburg, Russian Federation, 195197 | |
LCC Center of Palliative Medicine - Devita | Completed |
Sankt-peterburg, Sankt Petersburg, Russian Federation, 197343 | |
Private Healthcare Institution Clinical Hospital RZhD Medicine | Completed |
St. Petersburg, Sankt Petersburg, Russian Federation, 195271 | |
Pyatigorsky Oncologic Dispensary | Completed |
Pyatigorsk, Stavropol, Russian Federation, 357524 | |
Belgorod Regional Oncology Dispensary; Chemotherapy | Withdrawn |
Belgorod, Russian Federation, 308010 | |
Regional Oncology Hospital | Completed |
Irkutsk, Russian Federation, 664035 | |
Ivanovo Regional Oncology Dispensary | Completed |
Ivanovo, Russian Federation, 153040 | |
GUZ Kaluga Regional Oncological Dispensary | Recruiting |
Kaluga, Russian Federation, 248007 | |
Regional Oncology Dispensary; Dept of Chemotherapy | Completed |
Novgorod Veliky, Russian Federation, 173016 | |
BIH at Omsk Region "Clinical Oncology Dispensary", Outpatient clinic | Completed |
Omsk, Russian Federation, 644013 | |
Multidisciplinary clinic Reaviz | Completed |
Samara, Russian Federation, 443011 | |
Samara Regional Oncology Dispensary | Completed |
Samara, Russian Federation, 443031 | |
Regional Clinical Hospital | Completed |
Saratov, Russian Federation, 410053 | |
SHI Volgograd Regional Clinical Oncological Dispensary#1 | Completed |
Volgograd, Russian Federation, 400138 | |
Singapore | |
National University Hospital; Medical Oncology | Completed |
Singapore, Singapore, 119074 | |
National Cancer Centre | Completed |
Singapore, Singapore, 169610 | |
Tan Tock Seng Hospital; Oncology | Withdrawn |
Singapore, Singapore, 308433 | |
Spain | |
Hospital de Torrevieja; Servicio de Oncologia | Withdrawn |
Torrevieja, Alicante, Spain, 03186 | |
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia | Completed |
Badalona, Barcelona, Spain, 08916 | |
Hospital General De Catalunya; Servicio de Oncologia | Completed |
Sant Cugat Del Valles, Barcelona, Spain, 28981 | |
Hospital Mutua de Terrassa; Servicio de Oncologia | Completed |
Terrassa, Barcelona, Spain, 08221 | |
Consorci Hospitalari de Terrassa | Completed |
Terrassa, Barcelona, Spain, 08227 | |
Hospital de Jerez | Completed |
Jerez De La Frontera, Cadiz, Spain, 11407 | |
Hospital Provincial Castellón | Completed |
Castellon DE LA Plana/castello DE LA Plana, Castellon, Spain, 12002 | |
Hospital de Donostia.; Servicio de Oncología Radioterápica | Withdrawn |
San Sebastián, Guipuzcoa, Spain, 20014 | |
Hospital Son Llatzer | Completed |
Palma de Mallorca, Islas Baleares, Spain, 07198 | |
Centro Oncologico de Galicia COG; Medical Oncology | Completed |
A Coruna, LA Coruña, Spain, 15009 | |
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia | Withdrawn |
A Coruña, LA Coruña, Spain, 15006 | |
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia | Completed |
Santiago de Compostela, LA Coruña, Spain, 15706 | |
Hospital Universitario Puerta de Hierro - Majadahonda | Completed |
Majadahonda, Madrid, Spain, 28220 | |
Hospital Universitario Rey Juan Carlos de Móstoles; Servicio de Neurología | Withdrawn |
Móstoles, Madrid, Spain, 28933 | |
Hospital Infanta Cristina; Servicio de Oncologia | Recruiting |
Parla, Madrid, Spain, 28981 | |
Hospital Infanta Sofia; Servico de Oncologia | Completed |
San Sebastian de Los Reyes, Madrid, Spain, 28702 | |
Complexo Hospitalario de Vigo. Hospital Álvaro Cunqueiro; Servicio de Oncología | Completed |
Vigo, Pontevedra, Spain, 36312 | |
Hospital Universitari Sant Joan de Reus; Planta baja, color lila | Completed |
Reus, Tarragona, Spain, 43204 | |
Hospital Universitario de Canarias;servicio de Oncologia | Completed |
La Laguna, Tenerife, Spain, 38320 | |
Hospital General Univ. de Alicante; Servicio de Oncologia | Withdrawn |
Alicante, Spain, 3010 | |
Hospital del Mar | Active, not recruiting |
Barcelona, Spain, 08003 | |
Hospital Santa Creu i Sant Pau | Recruiting |
Barcelona, Spain, 08041 | |
Hospital Universitario de Burgos | Completed |
Burgos, Spain, 09006 | |
Hospital San Pedro De Alcantara; Servicio de Oncologia | Completed |
Caceres, Spain, 10003 | |
Complejo Hospitalario de Jaen | Completed |
Jaen, Spain, 23007 | |
Complejo Asistencial Universitario de Leon; Servicio de Oncologia | Completed |
Leon, Spain, 24071 | |
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia | Completed |
Madrid, Spain, 28007 | |
MD Anderson Cancer Center | Withdrawn |
Madrid, Spain, 28033 | |
Hospital Ruber Internacional;Servicio de Oncologia | Recruiting |
Madrid, Spain, 28034 | |
Hospital Universitario Ramón y Cajal | Completed |
Madrid, Spain, 28034 | |
Hospital Universitario 12 de Octubre; Servicio de Oncologia | Completed |
Madrid, Spain, 28041 | |
Hospital Universitario La Paz; Servicio de Oncologia | Withdrawn |
Madrid, Spain, 28046 | |
Centro Integral Oncológico Clara Campal Ensayos Clínicos START | Completed |
Madrid, Spain, 28050 | |
Hosp Univ Fundacion Alcorcon | Completed |
Madrid, Spain, 28922 | |
Hospital Universitario de Fuenlabrada; Servicio de Oncologia | Completed |
Madrid, Spain, 28943 | |
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia | Completed |
Malaga, Spain, 29010 | |
Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia | Completed |
Murcia, Spain, 30120 | |
Hospital Quirón Sagrado Corazón | Completed |
Sevilla, Spain, 41013 | |
Hospital Universitario Virgen de la Macarena; | Recruiting |
Sevilla, Spain, 41071 | |
Instituto Valenciano Oncologia; Oncologia Medica | Completed |
Valencia, Spain, 46009 | |
Hospital Clinico Universitario de Valencia | Completed |
Valencia, Spain, 46010 | |
Hospital General Universitario de Valencia; Servicio de oncologia | Completed |
Valencia, Spain, 46014 | |
Hospital Arnau de Vilanova (Valencia) | Recruiting |
Valencia, Spain, 46015 | |
Hospital Universitari i Politecnic La Fe; Oncologia | Completed |
Valencia, Spain, 46026 | |
Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia | Completed |
Zaragoza, Spain, 50009 | |
Switzerland | |
Hirslanden Medical Center - Tumorzentrum | Completed |
Aarau, Switzerland, 5000 | |
Inselspital Bern; Universitätsklinik für medizinische Onkologie | Withdrawn |
Bern, Switzerland, 3010 | |
Centre Hospitalier Universitaire Vaudois - Lausanne | Completed |
Lausanne, Switzerland, 1011 | |
Kantonsspital Olten; Medizinische Klinik | Withdrawn |
Olten, Switzerland, 4600 | |
Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich | Completed |
Zürich, Switzerland, 8008 | |
Taiwan | |
Chunghua Christian hospital | Completed |
Changhua, Taiwan, 500 | |
Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital | Completed |
Kaoshiung City, Taiwan, 807 | |
E-Da Cancer Hospital; Hematology- Oncology Department | Completed |
Kaoshiung, Taiwan, 824 | |
Chi Mei Medical Center Liou Ying Campus | Completed |
Liuying Township, Taiwan, 736 | |
Taipei Medical University ?Shuang Ho Hospital | Recruiting |
New Taipei City, Taiwan, 23561 | |
China Medical University Hospital;Oncology and Hematology Office Critical Care Center, 14H | Completed |
Taichung, Taiwan, 404 | |
National Cheng Kung University Hospital | Completed |
Tainan, Taiwan, 70457 | |
Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology | Recruiting |
Taipei City, Taiwan, 11259 | |
Taipei Veterans General Hospital | Completed |
Taipei City, Taiwan, 112 | |
National Taiwan University Hospital | Completed |
Taipei, Taiwan, 10002 | |
Mackay Memorial Hospital - Taipei Branch | Completed |
Taipei, Taiwan, 104 | |
Tri-Service General Hospital | Completed |
Taipei, Taiwan, 11490 | |
Chang Gung Medical Foundation Linkou Branch | Completed |
Taoyuan City, Taiwan, 333 | |
Thailand | |
Bhumibol Adulyadej Hospital; Medicine | Withdrawn |
Bangkok, Thailand, 10220 | |
Rajavithi Hospital; Division of Medical Oncology | Completed |
Bangkok, Thailand, 10400 | |
Ramathibodi Hospital; Medicine/Oncology | Completed |
Bangkok, Thailand, 10400 | |
Siriraj Hospital; Clinical Research Center, Pharmacy Department | Recruiting |
Bangkok, Thailand, 10700 | |
Chiang Rai Prachanukroh Hospital; Department Of Medicine | Recruiting |
Chiang Rai, Thailand, 57000 | |
Songklanagarind Hospital | Completed |
Hat Yai, Thailand, 90110 | |
Srinagarind Hospital, Khon Kaen University | Completed |
Khon Kaen, Thailand, 40002 | |
Lampang Cancer Hospital | Completed |
Muang Lampang, Thailand, 52000 | |
King Chulalongkorn Memorial Hospital; Faculty of Medicine Chulalongkorn University | Completed |
Patumwan, Thailand, 10330 | |
Turkey | |
Adana Ac?badem Hospital Oncology Department | Recruiting |
Adana, Turkey, 01130 | |
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi | Recruiting |
Adana, Turkey, 01240 | |
Gülhane E?itim Ve Ara?t?rma Hastanesi | Recruiting |
Ankara, Turkey, 06010 | |
Hacettepe Universitesi Onkoloji Hastanesi | Recruiting |
Ankara, Turkey, 06100 | |
Memorial Antalya Hospital | Recruiting |
Antalya, Turkey, 07025 | |
Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi | Recruiting |
Bursa, Turkey, 16059 | |
Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi | Recruiting |
Edirne, Turkey, 22030 | |
Ba?c?lar Medipol Mega Üniversite Hastanesi; Oncology | Recruiting |
Istanbul, Turkey, 34214 | |
T.C. Saglik Bakanligi Istanbul Il Saglik Mudurlugu Prof. Dr. Cemil Tascioglu Sehir Hastanesi | Recruiting |
Istanbul, Turkey, 34384 | |
T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin City Hospital | Recruiting |
Istanbul, Turkey, 34722 | |
Kartal Dr Lutfi Kirdar Sehir Hastanesi; Medical Oncology Department | Recruiting |
Istanbul, Turkey, 34865 | |
Ege Universitesi Hastanesi (Saglik Uygulama ve Arastirma Merkezi) | Recruiting |
Izmir, Turkey, 35100 | |
Izmir Ekonomi Universitesi Medical Park Hastanesi | Recruiting |
Izmir, Turkey, 35575 | |
Kocaeli Universitesi Tip Fakultesi Arastirma ve Uygulama Hastanesi | Recruiting |
Kocaeli, Turkey, 41380 | |
Inonu Universitesi Turgut Ozal Tip Merkezi | Recruiting |
Malatya, Turkey, 44280 | |
Mersin Universitesi Tip Fakultesi Hastanesi; Tibbi Onkoloji Birimi | Recruiting |
Mersin, Turkey, 33110 | |
Medikal Park Samsun | Completed |
Samsun, Turkey, 55200 | |
Vehbi Koc Vakfi (VKV) - Amerikan Hastanesi | Recruiting |
Te?v?k?ye, Turkey, 34365 | |
Ukraine | |
Yulis Medical and Diagnostic Center | Completed |
Zaporizhzhia, Katerynoslav Governorate, Ukraine, 69061 | |
Municipal Noncommercial Institution Regional Center of Oncology | Recruiting |
Kharkiv, Kharkiv Governorate, Ukraine, 61070 | |
MI "Clinical Oncological Dispensary" of Dnipro Reg Council; chemotherapy department | Completed |
Dnipro, KIEV Governorate, Ukraine, 49100 | |
Municipal Institution Odesa Regional Oncology Dispensary | Completed |
Odesa, KIEV Governorate, Ukraine, 65055 | |
Vinnytsya Regional Clinical Oncology Dispensary | Completed |
Vinnytsya, Podolia Governorate, Ukraine, 21029 | |
Regional Oncology Center; Department of Mammology | Completed |
Chernigiv, Ukraine, 14029 | |
Chernivtsi Regional Clinical Oncology Dispensary | Completed |
Chernivtsi, Ukraine, 58013 | |
Municipal Institution Kirovograd Regional Oncology Dispensary | Completed |
Kirovograd, Ukraine, 25011 | |
ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council; Chemotherapy Department | Completed |
Kryvyi Rih, Ukraine, 50048 | |
Kyiv Regional Oncological Dispensary | Withdrawn |
Kyiv, Ukraine, 04107 | |
Volyn Regional Oncology Dispensary | Completed |
Lutsk, Ukraine, 43018 | |
Lviv State Oncological Regional Treatment and Diagnostic Center | Completed |
Lviv, Ukraine, 79031 | |
Municipal Institution Odesa Regional Clinical Hospital | Completed |
Odesa, Ukraine, 65025 | |
Sumy Reg. Clin. Oncological Dispensary; Thoracall Department | Completed |
Sumy, Ukraine, 40005 | |
CCCH City Oncological Center SHEI Uzhgorod NU | Completed |
Uzhgorod, Ukraine, 88000 | |
Transkarpathian Regional Oncology Clinic; Chemotherapy | Completed |
Uzhgorod, Ukraine, 88000 | |
Zaporizhzhia Regional Clinical Oncology Dispensary; Zaporizhzhya State Medical University | Terminated |
Zaporizhzhya, Ukraine, 69040 | |
United Kingdom | |
NHS Lothian - Western General Hospital; NHS Lothian - Western General Hospital | Completed |
Edinburgh, United Kingdom, EH4 2XU | |
NHS Greater Glasgow and Clyde; Beatson West of Scotland Cancer Centre | Active, not recruiting |
Glasgow, United Kingdom, G12 0YN | |
Calderdale and Huddersfield NHS Foundation Trust | Completed |
Huddersfield, United Kingdom, HD3 3EA | |
Leeds Teaching Hosp NHS Trust;St James's Institute of Onc | Completed |
Leeds, United Kingdom, LS9 7TF | |
Guys and St Thomas NHS Foundation Trust, Guys Hospital | Recruiting |
London, United Kingdom, SE1 9RT | |
Sarah Cannon Research Institute | Withdrawn |
London, United Kingdom, W1G 6AD | |
The Christie NHS Foundation Trust | Completed |
Manchester, United Kingdom, M20 4BX | |
Mount Vernon Cancer Centre | Withdrawn |
Northwood, United Kingdom, HA6 2RN | |
Nottingham University Hospitals NHS Trust - City Hospital | Completed |
Nottingham, United Kingdom, NG5 1PB | |
North West Anglia NHS Foundation Trust | Withdrawn |
Peterborough, United Kingdom, PE3 9GZ | |
University Hospitals of North Midlands NHS Trust-Royal Stoke University Hospital | Completed |
Stoke-On-Trent, United Kingdom, ST4 6QG |
Study Director: | Clinical Trials | Hoffmann-La Roche |
Responsible Party: | Hoffmann-La Roche |
ClinicalTrials.gov Identifier: | NCT03498716 |
Other Study ID Numbers: |
WO39391 2016-003695-47 ( EudraCT Number ) BIG 16-05 ( Other Identifier: Breast International Group (BIG) ) AFT-27 ( Other Identifier: Alliance Foundation Trials ) ALEXANDRA ( Other Identifier: Breast International Group (BIG) ) |
First Posted: | April 17, 2018 Key Record Dates |
Last Update Posted: | May 22, 2023 |
Last Verified: | May 2023 |
Studies a U.S. FDA-regulated Drug Product: | Yes |
Studies a U.S. FDA-regulated Device Product: | No |
Breast Neoplasms Triple Negative Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Paclitaxel Cyclophosphamide Doxorubicin Atezolizumab Epirubicin Antineoplastic Agents, Phytogenic Antineoplastic Agents Tubulin Modulators Antimitotic Agents |
Mitosis Modulators Molecular Mechanisms of Pharmacological Action Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Antirheumatic Agents Antineoplastic Agents, Alkylating Alkylating Agents Myeloablative Agonists Antibiotics, Antineoplastic Topoisomerase II Inhibitors Topoisomerase Inhibitors Enzyme Inhibitors Immune Checkpoint Inhibitors Antineoplastic Agents, Immunological |