Genomic Profiling of the Residual Disease of Advanced-stage Ovarian Cancer After Neoadjuvant Chemotherapy
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|ClinicalTrials.gov Identifier: NCT03491033|
Recruitment Status : Completed
First Posted : April 6, 2018
Last Update Posted : April 10, 2018
|Condition or disease||Intervention/treatment|
|Advanced-stage Ovarian Cancer||Drug: chemotherapy|
|Study Type :||Observational|
|Actual Enrollment :||250 participants|
|Official Title:||Genomic Profiling of the Residual Disease of Advanced-stage Ovarian Cancer After Neoadjuvant Chemotherapy|
|Actual Study Start Date :||August 28, 2017|
|Actual Primary Completion Date :||October 31, 2017|
|Actual Study Completion Date :||October 31, 2017|
advanced-stage ovarian cancer group
250 patients with pathologically confirmed epithelial ovarian cancer who received at least 1 cycle of NAC at Yonsei Cancer Hospital from 2006 to 2017.
All of the patients in this study underwent NAC regimens consisting of taxane and platinum combination chemotherapy. After NAC, all of the patients underwent interval debulking surgery. Subsequently, additional cycles of chemotherapy were administered after IDS to complete a total of 6 cycles at the discretion of the treating physician.
- genomic profiling [ Time Frame: 3 months ]demonstrates the spectrum of genomic alterations/ profiling present in residual disease after neoadjuvant chemotherapy.
- immunohistochemistry [ Time Frame: 3 months ]To evaluate the prognostic significance of BRCA-1 IHC in residual disease after neoadjuvant chemotherapy in ovarian cancer
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03491033
|Korea, Republic of|
|Seoul, Korea, Republic of, 03722|