High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03487029|
Recruitment Status : Recruiting
First Posted : April 3, 2018
Last Update Posted : February 26, 2019
Aim: To assess whether there are different training effects on glucose concentration and cardiorespiratory parameters of different high-intensity training protocols in patients with type 2 diabetes.
Type 2 diabetes is a highly prevalent disease associated with cardiovascular disease leading to high levels of mortality, morbidity and health expenditure, characterized by impaired glucose control during activities and reduced aerobic exercise capacity .
Exercise training is the most effective way to improve compliance, reduce blood glucose concentration and increase insulin sensitivity. Training increases muscle capacity, oxidative capacity and glucose transport, peripheral insulin sensitivity is improved.
Exercise training with high-intensity interval (resting and exercise period) High Intensity Interval Training (HIIT) is a form of exercise training that has recently been widely used in the management of type 2 diabetes, including short duration high intensity exercise periods and lower severity or passive rest periods. There are different HIIT exercise training programs according to physiological responses in the literature. However, long-term and short-term HIIT training training programs were not compared in terms of their effect on glucose concentration and cardiorespiratory fitness. The aim of this study was to compare the effects of different HIIT exercise training programs so that exercise programs for patients with type 2 diabetes could be planned more effectively.
|Condition or disease||Intervention/treatment||Phase|
|Diabetes||Other: Short duration Other: Long duration||Not Applicable|
This study will be participated patients with Type 2 diabetes. Patients' laboratory values, pulmonary function test, respiratory muscle strength, exercise capacity, physical activity level, quality of life will be evaluated.
Pulmonary function test will be assesed with spirometer, respiratory muscle strength will be evaluated with mouth pressure. Exercise capacity will be evaluated using six minute walking test, incremental shuttle walk test, cycle ergometer. Muscle oxigeneration will be asssed with wearable lactate threshold predicting device. Physical activity level will be evaluated trial accelerometer.
Then, patients will be randomly divided two high intensity interval exercise training groups.
First group: short duration high intensity exercise training (Exercise load phase : 30sn %100 Patients performance, rest phase: 120sn %25 patients performance) Second group: Long duration high intensity interval exercise training (Exercise load phase : 4 dk %100 Patients performance, rest phase: 120sn %25 patients performance) All patients will participate three times a week during eight weeks. The muscle oxigeneration, blood glucose consantration, blood pressure, heart rate will be recorded before and after each exercise session. After 8 week, all test will be done again.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||The Effects of Different High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes|
|Actual Study Start Date :||March 2, 2018|
|Actual Primary Completion Date :||September 20, 2018|
|Estimated Study Completion Date :||December 20, 2019|
Experimental: short duration group
30sn %100 Wmax 120sn %25 Wmax 3 sessions/week total 8 weeks
Other: Short duration
exercise Short duration high intensity training
Other Name: training
Experimental: long duration group
4dk %85 Wmax 120sn %25 Wmax 3 sessions/week total 8 weeks
Other: Long duration
exercise Long duration high intensity training
Other Name: training
- muscle oxigeneration [ Time Frame: Change from baseline muscle oxigeneration at 8 weeks ]It is evaluate with wearable lactate threshold device on gastrocinemius
- The blood glucose consentration [ Time Frame: before and after 8 weeks ]It is evaluate with sample from blood
- Functional Exercise capacity [ Time Frame: before and after 8 weeks ]İt is evaluated with six minute walk test
- Maximal exercise capacity [ Time Frame: before and after 8 weeks ]İt is evaluated using with incremental shuttle test
- Symptom limited maximal exercise capacity [ Time Frame: before and after 8 weeks ]İt is evaluated with cycle ergometer test
- Lipit profile-High density lipoprotein cholesterol [ Time Frame: before and after 8 weeks ]High density lipoprotein cholesterol wiil be assesed
- Lipit profile- low density lipoprotein cholesterol [ Time Frame: before and after 8 weeks ]low density lipoprotein cholesterol wiil be assesed
- Lipit profile- trigliseride [ Time Frame: before and after 8 weeks ]trigliseride wiil be assesed
- pulmonary parameter-Forced vital capacity [ Time Frame: before and after 8 weeks ]Forced vital capacity will be evaluated
- pulmonary parameter-Forced vital capacity in the first second [ Time Frame: before and after 8 weeks ]Forced vital capacity in the first second will be evaluated
- pulmonary parameter-Mid expiratory flow rate [ Time Frame: before and after 8 weeks ]Mid expiratory flow rate will be evaluated
- pulmonary parameter-Peak expiratory flow [ Time Frame: before and after 8 weeks ]Peak expiratory flow will be evaluated
- Respiratory muscle strength [ Time Frame: before and after 8 weeks ]It is evaluated with mouth pressure
- Physical activity level [ Time Frame: before and after 8 weeks ]ıt is assessed using accelerometer
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03487029
|Contact: cemile bozdemir email@example.com|
|Ankara, State, Turkey, 06100|
|Contact: cemile bozdemir özel 0905352138084 firstname.lastname@example.org|
|Principal Investigator:||Cemile Bozdemir Özel, McS||Hacettepe University Physiotherapy and Rehabilitation|