Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Effect of Impulsivity and Decision Making Style on Brain Volume

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03483220
Recruitment Status : Enrolling by invitation
First Posted : March 30, 2018
Last Update Posted : January 15, 2019
Sponsor:
Information provided by (Responsible Party):
Sayed Mostafa, Assiut University

Brief Summary:

drug addiction is a major health hazard that has its effect on personality and behavior including the impulsivity and pattern of decision making. It also has its effect on both the structure and function of different brain regions mainly the prefrontal cortex.

the aim of the study is to study the decision making styles and impulsivity among people with different psychoactive substance addiction, studying the change in the volume of prefrontal cortex in relation to drug addiction and studying the relation between drug impulsivity, decision making patterns and brain volume.


Condition or disease Intervention/treatment
Addiction Diagnostic Test: MRI brain

Show Show detailed description

Layout table for study information
Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Impulsivity and Decision Making Style Among Drug Addicts and Its Relation to Volume of Prefrontal Cortex
Actual Study Start Date : August 30, 2018
Estimated Primary Completion Date : August 2019
Estimated Study Completion Date : December 2019

Group/Cohort Intervention/treatment
cases
patients with substance use disorder
Diagnostic Test: MRI brain
  1. Addiction severity index 4th version for assessment of addiction pattern.
  2. UPPS-P Impulsive Behavior Scale is a 59-item inventory designed to measure five distinct personality pathways to impulsive behavior: Negative Urgency, Lack of Perseverance, Lack of Premeditation, Sensation Seeking, and Positive Urgency.
  3. Iowa gambling task computerized version: The task involved drawing one card per trial from one of four decks (labeled as A, B, C, and D). Each deck contained 40 cards in a fixed sequence which is unknown to participants at the start of the task. Next, participants are asked to select cards from the four decks to gain as much money as possible. The task ends when the 100th card is drawn, although subjects do not know this in advance.
  4. MRI brain examination:

    • Voxel based morphometry through analysis of 3D T1 weighted sequence in order to assess total intracranial volume.
    • Resting state functional MRI.
Other Names:
  • Iowa gambling task
  • UPPS-P Impulsive Behavior Scale
  • Addiction severity index




Primary Outcome Measures :
  1. degree of impulsivity in addicts [ Time Frame: 12 months ]
    the UPPS scale will be used to measure the degree of impulsivity. it is a 45-item self-report questionnaire that was designed to measure impulsivity across dimensions of the Five Factor Model of personality. The UPPS includes 4 sub-scales: lack of premediation, urgency, lack of perseverance, and sensation-seeking

  2. measuring the volume of prefrontal cortex in addicts [ Time Frame: 12 months ]
    MRI brain with voxel based morphometry will be used in measuring the volume of different parts of prefrontal cortex mainly the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), ventromedial prefrontal cortex (VMPFC)



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Sampling Method:   Non-Probability Sample
Study Population
20 participants with drug addiction diagnosed by DSM-5 criteria will be recruited from addiction unit at Assiut University hospitals
Criteria

Inclusion Criteria:

  • Age above 18 years.
  • Clearly consenting to participate in the study. . patient with substance use disorder

Exclusion Criteria:

  • Intoxication or withdrawal state.
  • Comorbid Axis I psychiatric disorder.
  • Comorbid Axis II psychiatric disorder.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03483220


Locations
Layout table for location information
Egypt
Assiut University
Assiut, Egypt, 71111
Sponsors and Collaborators
Assiut University
Investigators
Layout table for investigator information
Study Chair: Khaled AM Elbeh, professor Assiut University
Study Director: Yasser M Elsorogy, professor Assiut University
Study Director: Mohamed F Abdelaal, Lecturer Assiut University

Publications:

Layout table for additonal information
Responsible Party: Sayed Mostafa, Assistant lecturer of psychiatry, Assiut University
ClinicalTrials.gov Identifier: NCT03483220    
Other Study ID Numbers: MRI brain study in addiction
First Posted: March 30, 2018    Key Record Dates
Last Update Posted: January 15, 2019
Last Verified: January 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Sayed Mostafa, Assiut University:
Addiction, MRI, Decision making
Additional relevant MeSH terms:
Layout table for MeSH terms
Behavior, Addictive
Impulsive Behavior
Compulsive Behavior