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Cadence Modulation to Improve Well-Being, Kinematics and Aerobic Performance in Cyclists

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03482726
Recruitment Status : Completed
First Posted : March 29, 2018
Last Update Posted : December 26, 2019
Sponsor:
Information provided by (Responsible Party):
University of Wisconsin, Madison

Brief Summary:
This study will utilize a combination of cardiovascular analysis, 3D motion capture, and a software package, Metrifit, to monitor measures of well-being to comprehensively evaluate both the musculoskeletal and physiological responses following a HIIT training intervention at EOC as a means of improving performance and potentially reducing injury risk factors. This holistic approach of physiological and biomechanical factors is unprecedented. This is the first interventional study to determine the effect of high intensity training at EOC on cardiovascular performance, kinematics and well-being which may minimize risk of injury factors.

Condition or disease Intervention/treatment Phase
Healthy Behavioral: Cycling Cadence Modulation Not Applicable

Detailed Description:

In the first session, each individual will be asked to fill out a questionnaire to regarding cycling experience, prior bike fits (with data sheets when available), and injury history. Maximal aerobic capacity (VO2max) will be determined. During the test, subjects will be asked rate exertion. Before testing, the system will be calibrated with known oxygen and carbon dioxide concentrations. During the test, subjects will be asked to breathe normally through a low dead space bidirectional turbine. Inspired and expired gases will be analyzed for concentrations of O2 and CO2, to determine alveolar gas exchange. Total ventilation (VE), respiratory rate, oxygen consumption (VO2), carbon dioxide (VCO2) will be measured, and respiratory exchange ratio (RER; VCO2/VO2) will be calculated continuously during the test and expressed as a 30-second rolling average.

Participants will return 48 hours later, at which time EOC will be determined after a moderate intensity prolonged cycling exercise (PCE) at seven different cadences. Cadences from 50rpm to 110rpm will be randomly generated and introduced every 3 minutes, followed by a 3 minute cool down at FCC at 40% PP (Figure Subjects will then be pair matched by gender and randomized into control (FCC) or EOC modulation groups.

48 hours following EOC testing, subject will return for a second progressive maximal cycling test performed at FCC or EOC based on group assignment.

Subjects will then participate in a 6 week high intensity training (HIIT) indoor cycling program at their prescribed cadence (FCC or EOC), using cadence meters. Training will consist of three non-consecutive days each week for 60 min, and alternate between two HIIT workouts. Resistance will be increased to meet the HIIT requirement, while cadence will remain at FCC or EOC. Subjects will be asked to warm-up at a light (3/10) workload for 10 minutes, followed by HIIT consisting of 4 minutes at an intensity of 8/10 on the modified Borg, and 90 seconds recovery (2/10). This will be repeated 8 times, followed by 10 minutes of cool down. The alternating HIIT workout will include a 10 minute warm up, followed by 12 intervals lasting 2 minutes at an RPE of 9/10 and 3 minutes of recovery. The session will conclude with a 10 minute cool down.

Within one week of completing their training program, subjects will return for their fourth and final study visit, at which time a VO2max test and kinematic data collection will be repeated at FCC or EOC.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 25 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Other
Official Title: Cadence Modulation to Improve Well-Being, Kinematics and Aerobic Performance in Cyclists
Actual Study Start Date : June 26, 2017
Actual Primary Completion Date : April 2, 2019
Actual Study Completion Date : April 2, 2019

Arm Intervention/treatment
Cycling Cadence Modulation
3 initial visits to collect baseline information; 6-week HIIT indoor cycling program at the individual prescribed cadence; final study visit for post-intervention measures.
Behavioral: Cycling Cadence Modulation
6-week high intensity training (HIIT) indoor cycling program, described later, at their prescribed cadence (FCC or EOC), using cadence meters.




Primary Outcome Measures :
  1. Time to exhaustion T(max) [ Time Frame: Baseline ]
    time to reach exhaustion

  2. Ventilatory threshold (VT) [ Time Frame: Baseline ]
  3. Maximal cardiac output [ Time Frame: Baseline ]
  4. Maximal stroke volume [ Time Frame: Baseline ]
  5. decreased trunk lean [ Time Frame: Baseline ]
    decrease in degree of lean in truck

  6. decreased ankle dorsiflexion [ Time Frame: Baseline ]
    decrease in amount of ankle dorsiflexion

  7. decreased knee splay [ Time Frame: Baseline ]
    decreased degree of knee splay


Secondary Outcome Measures :
  1. Improved VO2 max [ Time Frame: 6 weeks ]
    Increased maximum O2 volume

  2. Increased O2 consumption at VT [ Time Frame: 6 weeks ]
    Improved oxygen consumption at ventilatory threshold

  3. Time to VT [ Time Frame: 6 weeks ]
    Improved time to reach ventilatory threshold

  4. Time to T(max) [ Time Frame: 6 weeks ]
    Improved time to reach exhaustion

  5. decreased trunk lean [ Time Frame: 6 weeks ]
    decrease in degree of lean in truck

  6. decreased ankle dorsiflexion [ Time Frame: 6 weeks ]
    decrease in amount of ankle dorsiflexion

  7. decreased knee splay [ Time Frame: 6 weeks ]
    decreased degree of knee splay

  8. change in overall soreness and fatigue [ Time Frame: 6 weeks ]
    decrease in reported soreness and fatigue as measured and reported via Metrifit software



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 89 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. An experienced cyclist will be defined as one with at least 5 years of cycling experience and 5000 miles of training on a road bike with a clipless pedal system.
  2. Able to tolerate strenuous, maximal exercise and comply with a 6 week training protocol
  3. Have access to an indoor trainer or spin bike with a cadence sensor in order to train 3 times per week for 60 minutes

Exclusion Criteria:

  1. Taking medication which could impact cardiovascular function or performance (stimulants, beta-blockers, e.g.)
  2. Significant cardiac or pulmonary disease (congenital cardiac disease, uncontrolled hypertension, uncontrolled asthma, e.g.)
  3. Musculoskeletal injuries that preclude a maximal cycling effort and participation in training program

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03482726


Locations
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United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53705
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
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Principal Investigator: Andrew M Watson, MD University of Wisconsin, Madison

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Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT03482726    
Other Study ID Numbers: 2017-0131
A536110 ( Other Identifier: UW Madison )
SMPH\ORTHOPEDIC&REHAB\ORTHO ( Other Identifier: UW Madison )
First Posted: March 29, 2018    Key Record Dates
Last Update Posted: December 26, 2019
Last Verified: April 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by University of Wisconsin, Madison:
bicycle
cadence
cyclist
modulation