Seoul National University Pituitary Disease Cohort Study (SNU-PIT)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT03474601 |
Recruitment Status :
Recruiting
First Posted : March 22, 2018
Last Update Posted : March 18, 2020
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Condition or disease | Intervention/treatment |
---|---|
Pituitary Disease Pituitary Incidentaloma Acromegaly Central Diabetes Insipidus Pituitary Stalk Compression Hyperprolactinaemia Cushing's Disease Pituitary Tumor Prolactinoma | Other: Dynamic hormone study and Magnetic resonance imaging |
Study Type : | Observational |
Estimated Enrollment : | 1600 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Seoul National University Pituitary Disease Cohort Study |
Actual Study Start Date : | March 15, 2015 |
Estimated Primary Completion Date : | February 14, 2025 |
Estimated Study Completion Date : | February 14, 2025 |

Group/Cohort | Intervention/treatment |
---|---|
Acromegaly
Patients diagnosed with acromegaly
|
Other: Dynamic hormone study and Magnetic resonance imaging
|
Cushing's disease
Patients diagnosed with Cushing's disease
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Other: Dynamic hormone study and Magnetic resonance imaging
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Hyperprolactinemia/prolactinomas
Patients diagnosed with hyperprolactinemia/prolactinoma
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Other: Dynamic hormone study and Magnetic resonance imaging
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Pituitary stalk lesions
Patients diagnosed with pituitary stalk lesions
|
Other: Dynamic hormone study and Magnetic resonance imaging
|
Nonfunctioning pituitary adenomas
Patients diagnosed with nonfunctioning pituitary adenomas
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Other: Dynamic hormone study and Magnetic resonance imaging
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Central diabetes insipidus
Patients diagnosed with central diabetes insipidus
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Other: Dynamic hormone study and Magnetic resonance imaging
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Craniopharyngioma
Patients diagnosed with craniopharyngiomas
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Other: Dynamic hormone study and Magnetic resonance imaging
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Others
Patients diagnosed with other suprasellar/parasellar lesions
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Other: Dynamic hormone study and Magnetic resonance imaging
|
- Treatment outcome of pituitary diseases [ Time Frame: Up to 10 years ]Remission rate
- Complications of pituitary disease [ Time Frame: Up to 10 years ]Visual field defect or hypopituitarism, hormone hyperfunction-related complications
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
-
Subjects for this study will be recruited if they are:
- Adults, male or female aged 18 years or older
- diagnosed with pituitary diseases such as acromegaly, Cushing's disease, hyperprolactinemia, nonfunctioning pituitary adenoma, pituitary stalk lesions, central diabetes insipidus, and craniopharyngiomas
Exclusion Criteria:
- Patients who do not agree with the study

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03474601
Contact: Jung Hee Kim, M.D | 82-2-2072-4073 | jhkxingfu@gmail.com |
Korea, Republic of | |
Seoul National University Hospital | Recruiting |
Seoul, Korea, Republic of, 03080 | |
Contact: Jung Hee Kim, M.D jhkxingfu@gmail.com |
Principal Investigator: | Jung Hee Kim, M.D | Seoul National University Hospital |
Responsible Party: | Jung Hee Kim, Principal Investigator, Seoul National University Hospital |
ClinicalTrials.gov Identifier: | NCT03474601 |
Other Study ID Numbers: |
1503-040-654 |
First Posted: | March 22, 2018 Key Record Dates |
Last Update Posted: | March 18, 2020 |
Last Verified: | March 2019 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Pituitary Diseases Pituitary incidentaloma Central Diabetes Insipidus Pituitary Neoplasms |
Acromegaly Pituitary Neoplasms ACTH-Secreting Pituitary Adenoma Prolactinoma Pituitary Diseases Pituitary ACTH Hypersecretion Hyperprolactinemia Diabetes Insipidus Diabetes Insipidus, Neurogenic Hypothalamic Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Endocrine System Diseases Bone Diseases, Endocrine |
Bone Diseases Musculoskeletal Diseases Hyperpituitarism Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Hypothalamic Neoplasms Supratentorial Neoplasms Brain Neoplasms Central Nervous System Neoplasms Nervous System Neoplasms Adenoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Kidney Diseases |