Comparison of Oral Lamotrigine and Oral Pregabalin for Control of Acute and Chronic Pain
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03419949|
Expanded Access Status : Available
First Posted : February 2, 2018
Last Update Posted : February 6, 2018
Breast cancer is the most frequent neoplastic tumor in women, and surgical treatment is indicated in most patients. Complications related to this treatment, such as post-mastectomy pain syndrome (PMPS), a persistent pain that develops after surgery, have been reported. Although the genesis of the pain is multifactorial, sectioning of the intercostobrachial nerve is the nerve lesion diagnosed more often (1) ..
Pain relief using drugs with high efficacy provides significant improvement in the patients' lives. Drugs like lamotrigine (LTG) and gabapentin (GBP) have the ability to overcome the symptoms of neuropathic pain (4).
Both LTG and PGB have been extensively reviewed in the past for management of painful neuropathic conditions (5)
|Condition or disease||Intervention/treatment|
|Acute and Chronic Pain Following Modified Radical Mastectomy||Drug: oral lamotrigine 100 mg Drug: oral pregabalin 150 mg|
Show Detailed Description
|Study Type :||Expanded Access|
|Expanded Access Type :||Individual Patients|
|Official Title:||Comparison of Oral Lamotrigine and Oral Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy|
- Drug: oral lamotrigine 100 mg
Pain relief drug Lamotrigine inhibits the voltage-gated sodium and calcium channels. Inhibition of the voltage-gated sodium channel stabilizes the presynaptic neuronal membrane, thus preventing the release of excitatory neurotransmitters such as glutamate and inhibiting sustained repetitive neuronal firingOther Name: lamictal
- Drug: oral pregabalin 150 mg
Pain relief using drug Pregabalin is a structural analogue of the inhibitory neurotransmitter gama-aminobutyric acid (GABA), with anticonvulsant, antihyperalgesic, and anxiolytic propertiesOther Name: lyrica
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03419949
|Contact: salma firstname.lastname@example.org|