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Pathogen Screening in OA and Non-OA Orthopaedic Surgical Patients

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ClinicalTrials.gov Identifier: NCT03394170
Recruitment Status : Recruiting
First Posted : January 9, 2018
Last Update Posted : January 10, 2018
Sponsor:
Information provided by (Responsible Party):
The Foundation for Sports Medicine and Arthritis Research

Brief Summary:
The purpose of this study is to screen orthopedic surgery patients with and without a diagnosis of osteoarthritis for the presence of 11 pathogens associated with periodontal disease (PD) from a collection of oral rinse, synovial fluid and their synovium. The investigators hypothesize that there is a correlation between the presence of specific oral pathogens in saliva, synovial fluid and synovial tissue with clinical diagnosis of OA.

Condition or disease Intervention/treatment
Osteoarthritis, Knee Other: Collection of specimens prior to and during surgery

Detailed Description:

Osteoarthritis (OA) is the most common form of arthritis, affecting over 27 million people in the US. Rheumatoid arthritis (RA), a less common form of arthritis, is believed to differ from OA in its etiology, however both result in breakdown of cartilage. Studies have reported the association between chronic or adult periodontal disease (PD), Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobic bacterium, and rheumatoid arthritis (RA). Whether or not there is an infectious component of osteoarthritis is of significant interest.

The purpose of this study is to screen orthopedic surgery patients with and without a diagnosis of osteoarthritis for the presence of 11 pathogens associated with PD from a collection of oral rinse, synovial fluid and their synovium. The investigators hypothesize that there is a correlation between the presence of specific oral pathogens in saliva, synovial fluid and synovial tissue with clinical diagnosis of OA.

If an association between OA disease status and the presence of one or more pathogens can be confirmed, further studies can be undertaken to investigate the causative nature of oral pathogens in the clinical manifestation of OA, and eventually may lead to development of targeted therapies to prevent or slow the progression of OA.

This study will recruit 50 patients with indications for knee surgery, who fit the inclusion/exclusion criteria. Prior to surgery, patients will undergo an Institutional Review Board (IRB) approved informed consent process for in vitro cellular and biochemical characterization of their tissue. Two discreet populations, essentially normal knees and confirmed osteoarthritic knees will be studied. All patients will provide specimens for analysis, to identify the presence of oral pathogens in each participants saliva, synovial fluid and synovium.

Evaluation will include identifying the type and concentration of the following perio-pathogenic bacteria that are known to cause periodontal disease:

  • Aggregatibacter actinomycetemcomitans
  • Campylobacter rectus
  • Capnocytophaga species (gingivalis, ochracea, sputigena)
  • Eikenella corrodens
  • Eubacterium nodatum
  • Fusobacterium nucleatum/periodonticum
  • Parvimonas micra
  • Porphyromonas gingivalis
  • Prevotella intermedia
  • Tannerella forsythia
  • Treponema denticola

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Pathogen Screening in OA and Non-OA Orthopaedic Surgical Patients
Actual Study Start Date : May 1, 2017
Estimated Primary Completion Date : May 2018
Estimated Study Completion Date : June 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis

Group/Cohort Intervention/treatment
Osteoarthritis
Participants who are undergoing unicompartmental knee replacement will be considered OA status
Other: Collection of specimens prior to and during surgery
Collection of specimens prior to and during surgery
Other Name: Specimen collection

Non-Osteoarthritis
Participants with an acute injury (occurring no more than 90 days prior to surgery) with no history of knee injury or surgery, will be considered "Non-OA" status
Other: Collection of specimens prior to and during surgery
Collection of specimens prior to and during surgery
Other Name: Specimen collection




Primary Outcome Measures :
  1. Evidence of oral pathogens in knee joint [ Time Frame: 2 weeks ]
    Evidence of specified oral pathogens in the synovial fluid and/or tissue



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients attending The Stone Clinic for knee surgery as a result of a recent sports injury or known osteoarthritis can be considered if they fit the inclusion and exclusion criteria.
Criteria

Inclusion Criteria:

  • Skeletally mature (as evidenced by x-ray)
  • Aged 18 years or over
  • Patient will be undergoing orthopaedic surgery
  • If patient is "Non-OA," patient has no history of previous injury / surgery to operative joint
  • Patient is able to understand the requirements of the study, abide by the restrictions, and return for all required examinations and treatments.
  • Patient is able to give written informed consent

Exclusion Criteria:

  • A clinical diagnosis of inflammatory arthritis made by history, examination or serology.
  • An active or latent infection of the affected knee joint or any other systemic infection currently under treatment or treated within the previous 3 months.
  • A history of chronic alcohol or drug abuse during the six months prior to the study.
  • Clinically documented acute or unstable concomitant disease, other than the condition to be treated in this study that might affect make it difficult to interpret the patient's cartilage composition (i.e. renal, hepatic, cardiac, endocrine, hematologic, autoimmune, metabolic bone, crystal deposition, severe degenerative joint, neoplastic diseases).
  • Systemic administration, within twenty days prior to the procedure, of any type of corticosteroids, antineoplastic, immunostimulating or immunosuppressant agents.
  • Patients with a medical condition that interferes with their ability to participate in surgery or rehabilitation program.
  • Participation in any other investigational drug or device trial during the 30 days prior to screening visit or who will receive such a drug or device during the course of this study.
  • Pregnant females.
  • Subject's unable or unwilling to comply with the protocol or scheduled appointments.
  • Subject's unable to provide informed consent.
  • Subject's unable to understand verbal and/or written English.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03394170


Contacts
Contact: Susan Hennessy, PhD 415-921-1220 research@stoneresearch.org

Locations
United States, California
Stone Research Foundation Recruiting
San Francisco, California, United States, 94123
Contact: Susan Hennessy, PhD    415-921-1220    research@stoneresearch.org   
Sponsors and Collaborators
The Foundation for Sports Medicine and Arthritis Research
Investigators
Principal Investigator: Kevin R Stone, MD Foundation for Sports Medicine & Arthritis Research (Stone Research Foundation)

Responsible Party: The Foundation for Sports Medicine and Arthritis Research
ClinicalTrials.gov Identifier: NCT03394170     History of Changes
Other Study ID Numbers: SRF-025
First Posted: January 9, 2018    Key Record Dates
Last Update Posted: January 10, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Osteoarthritis
Osteoarthritis, Knee
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases