The Effect of Remote Ischemic Preconditioning in Living Donor Hepatectomy
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|ClinicalTrials.gov Identifier: NCT03386435|
Recruitment Status : Completed
First Posted : December 29, 2017
Last Update Posted : December 29, 2017
|Condition or disease||Intervention/treatment||Phase|
|Tissue Donors Liver Transplantation Ischemia Reperfusion Injury||Procedure: remote ischemic preconditioning||Not Applicable|
Liver ischemia/reperfusion (IR) injury (IRI) is a phenomenon in which cellular damage caused by hypoxia is accentuated following return of blood flow and restoration of oxygen delivery. This remains an important clinical problem during shock, hepatic resection, and liver transplantation.
Remote ischemic preconditioning (RIPC), involves brief periods of ischemia followed by reperfusion of one organ or tissue that subsequently affords protection to a remote organ or tissue suffering from a prolonged ischemic injury. RIPC of the limb reduces IRI to the heart, lungs, and other organs in humans and animals. Studies have investigated the protective effect of RIPC of the hind limb in reducing the adverse effects of liver IRI and underlying mechanism involved in increased hepatic blood ﬂow, the role of heme oxygenase, modulation of the hepatic microcirculation, the role of High Mobility Group-Box1and, and others.
However, impact of RIPC on living donor hepatectomy has not been elucidated. In this study, the investigators tried to elucidate the effects of RIPC on postoperative liver function test after living donor hepatectomy.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||148 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||study group : remote ischemic preconditioning control group : none|
|Masking Description:||single blind masking|
|Official Title:||The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial|
|Actual Study Start Date :||August 22, 2016|
|Actual Primary Completion Date :||August 31, 2017|
|Actual Study Completion Date :||October 30, 2017|
Active Comparator: RIPC group
received remote ischemic preconditioning
Procedure: remote ischemic preconditioning
transient brief episodes of ischemia at a remote site before a subsequent prolonged ischemia/reperfusion injury of the target organ
No Intervention: control group
- postoperative liver function [ Time Frame: 7 days ]laboratory findings in postoperative 7 days
- acute kidney injury [ Time Frame: 7 days ]serum creatinine levels in postoperative 7 days
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03386435
|Korea, Republic of|
|Asan medical center|
|Seoul, Songpa-gu, Korea, Republic of, 05505|
|Principal Investigator:||Jun-Gol Song, Ph.D.||Asan Medical Center|