Liraglutide on Decreasing Parenteral Support in Short Bowel Patients (SLIPS) (SLIPS)
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|ClinicalTrials.gov Identifier: NCT03371862|
Recruitment Status : Withdrawn (No participants recruited. Not able to recruit due to COVID 19.)
First Posted : December 13, 2017
Last Update Posted : August 14, 2020
|Condition or disease||Intervention/treatment||Phase|
|Short Bowel Syndrome||Drug: Liraglutide Pen Injector [Victoza]||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||Pilot study|
|Masking:||None (Open Label)|
|Official Title:||Pilot Study of the GLP-1 Agonist, Liraglutide, on Decreasing Parenteral Support Requirements in Short Bowel Patients.|
|Actual Study Start Date :||October 20, 2017|
|Actual Primary Completion Date :||August 6, 2020|
|Estimated Study Completion Date :||September 30, 2020|
|Experimental: Test group||
Drug: Liraglutide Pen Injector [Victoza]
Pilot study of liraglutide in patients with short bowel.
- Improvement in parenteral support [ Time Frame: 20 weeks post start of drug ]Improvement of parenteral support on 20 weeks of Liraglutide
- Improvement in quality of life [ Time Frame: 20 weeks post start of drug ]Improvement in Euroqol EQ5-D score. Level 1: indicating no problem, Level 5: indicating extreme problems.
- Duration of response [ Time Frame: 20 weeks ]Duration of response i.e. proportion of subjects who maintain reduction in weekly PN volume from baseline at week 20.
- Days/Nights not requiring PS [ Time Frame: 20 weeks ]Days/Nights not requiring PS
- Change in plasma citrulline, GLP-1, IGF-1 and PYY concentrations [ Time Frame: 20 weeks ]Change in plasma citrulline, GLP-1, IGF-1 and PYY concentrations
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03371862
|St Mark's Hospital|
|Harrow, United Kingdom, HA1 3UJ|
|Principal Investigator:||Siddhartha Oke||Imperial College London|