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The Quebec Family Study (QFS): Role of Genetic Factors in Obesity and Its Related Risk Factors and Diseases (QFS)

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ClinicalTrials.gov Identifier: NCT03355729
Recruitment Status : Completed
First Posted : November 28, 2017
Last Update Posted : November 28, 2017
Sponsor:
Collaborator:
Canadian Institutes of Health Research (CIHR)
Information provided by (Responsible Party):
Louis Pérusse, Laval University

Brief Summary:
The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour.

Condition or disease
Obesity Physical Fitness

Detailed Description:
The Quebec Family Study was an observational study with three cycles of data collection between 1978 and 1992. During the first cycle of data collection (Phase 1: 1978-1982), a total of 1,650 subjects from 375 families were recruited. During the second cycle (Phase 2: 1989-1997), 385 subjects from 105 phase 1 families were retested and an additional 372 subject from 74 families were recruited. During the third cycle (Phase 3: 1998-2002), 204 subjects from phase 1 were tested a third time, 113 subjects from phase 2 were tested a second time and 194 new subjects from 44 families were recruited.

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Study Type : Observational
Actual Enrollment : 951 participants
Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: The Quebec Family Study: an Observational Study Aimed at Investigating the Role of Genetic Factors in Physical Fitness, Obesity and Risk Factors for Common Diseases and Health-related Behaviours
Actual Study Start Date : June 1978
Actual Primary Completion Date : September 5, 2002
Actual Study Completion Date : September 5, 2002

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Body composition [ Time Frame: Through study completion, an average of 24 years ]
    Body composition as assessed by underwater weighing

  2. Body mass index (kg/m^2) [ Time Frame: Through study completion, an average of 24 years ]
    Body mass index assessed from height and weight

  3. Abdominal fat [ Time Frame: Through study completion, an average of 24 years ]
    Abdominal fat as assessed by commuted tomography

  4. Waist and hip circumferences (cm) [ Time Frame: Through study completion, an average of 24 years ]
    Waist and hip circumferences (cm)


Secondary Outcome Measures :
  1. Caloric intake [ Time Frame: Through study completion, an average of 24 years ]
    Total caloric intake and macronutrient intake using a 3-day dietary record

  2. Eating behaviour [ Time Frame: Through study completion, an average of 24 years ]
    Eating behaviour assessed using the Three-Factor Eating questionnaire

  3. Energy expenditure [ Time Frame: Through study completion, an average of 24 years ]
    Oxygen consumption at rest and during exercise

  4. Physical activity level [ Time Frame: Through study completion, an average of 24 years ]
    Physical activity level assessed by questionnaire

  5. Blood pressure (mm Hg) [ Time Frame: Through study completion, an average of 24 years ]
    Systolic and diastolic blood pressure

  6. Plasma lipid levels (mmol/L) [ Time Frame: Through study completion, an average of 24 years ]
    Fasting levels of triglycerides, LDL-cholesterol and HDL-cholesterol in mmo/L

  7. Glucose levels (mmol/L) [ Time Frame: Through study completion, an average of 24 years ]

    Plasma glucose levels in a fasting state and following an oral glucose tolerance test, inflammatory markers.

    Plasma glucose levels in a fasting state and during an oral glucose tolerance test


  8. Insulin levels (pmol/L) [ Time Frame: Through study completion, an average of 24 years ]
    Plasma insulin levels in a fasting state and following an oral glucose tolerance test.

  9. C-reactive protein (CRP in mg/ml) [ Time Frame: Through study completion, an average of 24 years ]
    C-reactive protein (CRP in mg/ml)

  10. Adiponectin levels (in micrograms/ml) [ Time Frame: Through study completion, an average of 24 years ]
    Adiponectin levels (in micrograms/ml)

  11. Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml [ Time Frame: Through study completion, an average of 24 years ]
    Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml

  12. Smoking habits (nb of cigarettes per day) [ Time Frame: Through study completion, an average of 24 years ]
    Smoking habits (nb of cigarettes per day)

  13. Sleeping (hours/day) [ Time Frame: Through study completion, an average of 24 years ]
    Sleeping (hours/day)

  14. Alcohol consumption [ Time Frame: Through study completion, an average of 24 years ]
    Alcohol consumption (nb of drinks per week)


Biospecimen Retention:   Samples With DNA
DNA is available from subjects that were enrolled in Phases 2 and 3 of the study


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   10 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
The QFS cohort is a mixture of random sampling and ascertainment through obese individuals. In Phase 1 of the study, subjects were randomly selected from French-Canadian families living in the Quebec city area, In Phases 2 and 3 of the study, families with a least one obese parent and one obese offspring were recruited.
Criteria

Inclusion Criteria:

  • Age over 10 years

Exclusion Criteria:

  • Not applicable

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03355729


Sponsors and Collaborators
Louis Pérusse
Canadian Institutes of Health Research (CIHR)
Investigators
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Principal Investigator: Claude Bouchard, Ph.D. Pennington Biomedical Center
Study Director: Louis Perusse, Ph.D. Laval University
Additional Information:
Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Louis Pérusse, Professor, Laval University
ClinicalTrials.gov Identifier: NCT03355729    
Other Study ID Numbers: 2010-075 CG
First Posted: November 28, 2017    Key Record Dates
Last Update Posted: November 28, 2017
Last Verified: November 2017

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms