Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa for Ovarian Stimulation in Donors
|ClinicalTrials.gov Identifier: NCT03354494|
Recruitment Status : Completed
First Posted : November 28, 2017
Last Update Posted : November 28, 2017
Currently, controlled ovarian stimulation (COS) in oocyte donors is performed by daily injections of gonadotropins( recombinant FSH) plus a GnRH Antagonist usually form 5th-6th stimulation day until ovulation induction with a bolus of another injection of a gonadotropin-releasing hormone (GnRH) Agonist. Injections of the GnRH Antagonist avoid untimely luteinizing hormone (LH) surge and spontaneous ovulation prior to follicular aspiration. There is a preparation of long-acting recombinant follicle stimulating hormone (rFSH= (corifollitropin alfa (FSH-CTP), Elonva®, MSD), that allows that a single subcutaneous injection substitutes the first 7 days of daily gonadotropin injections. On the other hand, a contraceptive oral progesterone only( Desogestrel, DSG) is available for contraception, avoiding the LH surge.
In donors, by administering a single injection of FSH-CTP and oral desogestrel since the first menstruation day, the total number of injections administered is reduced and less discomfort is experienced without adverse impact on ovarian response.
Other authors have reported good results using similar synthetic progestins (Medroxyprogesterone, dihydrogesterone, and natural progesterone).
No description of the hormonal and ovarian response under this protocol has been published. Direct comparison between this novel protocol and the classical GnRH- antagonist plus daily gonadotropins has not been reported.
|Condition or disease||Intervention/treatment|
|Controlled Ovaria Stimulation||Drug: Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa|
|Study Type :||Observational|
|Actual Enrollment :||40 participants|
|Official Title:||Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa for Ovarian Stimulation in Donors|
|Actual Study Start Date :||January 2016|
|Actual Primary Completion Date :||June 2017|
|Actual Study Completion Date :||September 2017|
Drug: Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa
- Total dose of gonadotrophins [ Time Frame: At the end of stimulation treatment period (from day of corifollitropin administration until the day of triggering) ) an average 10 days after beginning treatment ]Sum of gonadotrophins dose
- Oocyte retrieved [ Time Frame: Oocyte retrieval day an average 10 days after beginning treatment ]Number of oocyte retrieved