Celebrex Premedication in Teeth With Symptomatic Irreversible Pulpitis
|ClinicalTrials.gov Identifier: NCT03339544|
Recruitment Status : Unknown
Verified November 2017 by Yousra Khaled Mohamed Ezzat, Cairo University.
Recruitment status was: Not yet recruiting
First Posted : November 13, 2017
Last Update Posted : November 13, 2017
|Condition or disease||Intervention/treatment||Phase|
|Pulpitis||Drug: Celebrex premedication Drug: Placebo||Not Applicable|
Owing to the painful nature of endodotnic treatment in teeth with irreversible pulpits, administration of an analgesic and anti-inflammatory could help to lessen the perception of pain, hence decreasing the patient apprehension.
Previous clinical trials have shown that the use of NSAIDS as a premedication prior to endodontic treatment was effective in reducing the pain and increasing the anesthetic success, since as high as 80% of the patients with pre-operative pain experience pain after endodontic treatment.
In this study, Celebrex (Celecoxib) 200mg will be given to the patients 1 hour before initiation of the treatment, and its effect on reducing the pain will be compared with a placebo.
Celebrex being a selective COX-2 inhibitor, it will spare the physiological tissue prostaglandin production while inhibiting the inflammatory prostaglandin production thus allow for effective analgesia with fewer side effects than Non-Selective NSAIDS (nsNSAIDS).
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||46 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effect of Celebrex Pre-medication on the Intra and Post-treatment Endodontic Pain in Teeth With Symptomatic Irreversible Pulpitis: Double Blind Randomized Clinical Trial|
|Estimated Study Start Date :||December 1, 2017|
|Estimated Primary Completion Date :||December 1, 2018|
|Estimated Study Completion Date :||December 2019|
Experimental: Celebrex premedication
Celebrex is a NSAID with selective COX-2 inhibition properties, is given as an intervention to assess the pain
Drug: Celebrex premedication
celebrex (celecoxib) 200mg is a non-steroidal anti-infalmmatory drug with selective COX-2 inhibition.
Other Name: Celecoxib
Placebo Comparator: Placebo tablets
placebo tablets to compare the efficacy of Celebrex on the intra-operative and post-operative pain accompanying endodontic treatment of teeth with irreversible pulpits
placebo is given as a tablet before initiation of endodontic treatment
- pain intensity (intra-operative pain) [ Time Frame: 1 hour after administration of the drug up to 2 hours till the end of endodontic treatment ]pain intensity during endodontic treatment, measured by Visual Analogue Scale (pain scale)
- alleviation of pain severity [ Time Frame: 24 hours ]severity of pain is measured by Visual Analogue Scale
- number of analgesic tablets taken by the patient after endodontic treatment [ Time Frame: 24 hours ]counting the number of analgesic tablets taken by the patient after the treatment
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03339544
|Contact: Yousra Khaledemail@example.com|
|Contact: Geraldine Ahmedfirstname.lastname@example.org|