Oxytocin Administration and Emotion Recognition Abilities in Adults Reporting Adverse Childhood Experiences
|ClinicalTrials.gov Identifier: NCT03335085|
Recruitment Status : Completed
First Posted : November 7, 2017
Last Update Posted : November 7, 2017
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Drug: Oxytocin Other: Placebo||Not Applicable|
Adverse childhood experience such as neglect or abuse can lead to long-term deficits in emotion processing abilities, and these effects might be mediated via alterations in oxytocin production or sensitivity. The goal of this study was to test whether emotion recognition abilities and empathy might be improved by intranasal oxytocin administration in adults with a history of childhood maltreatment.
In a double-blind, placebo-controlled experiment with a crossover design, we assessed the performance of 40 healthy participants with a history of childhood adversity on the Reading the Mind in the Eyes Test (RMET) and an emotion recognition task under 24 IU oxytocin vs. placebo and compared them to a control group of 40 matched individuals without traumatic childhood experiences.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||80 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Long-term Consequences of Childhood Adversity: Exploring Stress Responsive Molecular Pathways and Psychobiological Intervention Models|
|Actual Study Start Date :||July 1, 2011|
|Actual Primary Completion Date :||March 23, 2013|
|Actual Study Completion Date :||November 5, 2013|
Active Comparator: Oxytocin
Single dose of intranasally administered 24 IU of Oxytocin (Syntocinon-Spray Novartis, Switzerland)
Other Name: Syntocinon
Placebo Comparator: Placebo
All ingredients except for oxytocin.
- Reading the Mind in the Eyes Test [ Time Frame: 45 minutes post-dose ]Requires participants to infer complex mental states fromthe eye region
- Gradual Emotion Recognition Test [ Time Frame: 50 minutes post-dose ]Requires participants to swiftly and accurately detect basic emotions form naturalistic, animated stimuli.