Evolution of the Heart Function When Monitoring Immunotherapies Anti-cancerous Inhibiting PD-1
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ClinicalTrials.gov Identifier: NCT03313544 |
Recruitment Status :
Not yet recruiting
First Posted : October 18, 2017
Last Update Posted : October 18, 2017
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Prospective, monocentric clinical study. Patients selected for nivolumab therapy in AP-HM for melanoma and non-small cell lung cancer will be eligible. Do not include patients with conditions that do not allow MRI, prior cardiovascular disease with LVEF<50%, cardiomyopathy, history of cardiac arrhythmia, history of cardiovascular toxicity under anticancer therapy, coronary artery disease or stroke less than 3 months Therapeutic management will not be modified and treatment will be administrated as usual.
Cardiovascular follow up will be identical to that recommended and realized in current care in the Cardio-Oncology unit of AP-HM. It will include clinical, biological (BNP and troponin) and trans-thoracic echocardiography (TTE) at baseline and then at 1, 3 and 6 months. Auto-antibodies against troponin I assay will be performed to avoid false negatives of normal blood level of troponin I at baseline and then at 6 months. Cardiac MRI will be performed as well at baseline and at the end of the study (6 months). MRI is the gold standard for ventricular function evaluation.
Primary endpoint will be left ventricular function evolution evaluated by global longitudinal strain (GLS, 2D speckles tracking) in TTE. Secondary endpoints will be left and right ventricular function parameters: LEVF by TTE and MRI, left ventricular indexed volumes by TTE and MRI, right ejection ventricular function and indexed volumes by TTE and MRI, systolic pulmonary arterial pressure by TTE, serum troponin I and BNP, arrhythmias and conduction disorders on the electrocardiogram (ECG).
Number of required subjects: GLS is recommended for following up left ventricular function under anticancer treatments. Based on the hypothesis of a significant GLS decrease (15%) in 20% of cases with alpha risk of 0.05 and accuracy of 0.12 which means expected confidence interval of 0.08-0.32, then the number of required subjects is 50 patients.
The inclusion period will be 18 months with a follow up if 6 months, ie a total duration of the study of 24 months.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Melanoma Non-small Cell Lung Cancer | Drug: Nivolumab Device: MRI Biological: BLOOD SAMPLES Device: trans-thoracic echocardiography | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 50 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Diagnostic |
Official Title: | Evolution of the Heart Function When Monitoring Immunotherapies Anti-cancerous Inhibiting Programmed Cell Death 1 (PD-1) |
Estimated Study Start Date : | October 2017 |
Estimated Primary Completion Date : | October 2020 |
Estimated Study Completion Date : | March 2021 |

Arm | Intervention/treatment |
---|---|
Experimental: NIVOLUMAB PATIENTS |
Drug: Nivolumab
NIVOLUMAB Device: MRI Cardiac MRI 6 MONTHS Biological: BLOOD SAMPLES biological (BNP and troponin) Device: trans-thoracic echocardiography 1, 3 and 6 months |
- systolic pulmonary arterial pressure [ Time Frame: 6 months ]trans-thoracic echocardiography
- ventricular function evaluation. [ Time Frame: 6 MONTHS ]MRI
- serum troponin I [ Time Frame: 1,3, 6 months ]BLOOD SAMPLES
- Brain natriuretic peptide (BNP) [ Time Frame: 1,3, 6 months ]BLOOD SAMPLES

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
patients treated with nivolumab
Exclusion Criteria:
- Age <18 years
- Preliminary cardiac disease with FeVG <50%
- Cardiomyopathy dilated, hypertrophic or restrictive
- History of cardiac arrhythmia
- History of cardiac toxicity under another anti-cancer treatment
- Known coronary disease
- History of stroke less than 3 months old
- Patient not wishing to participate in the study
- Vulnerable persons (pregnant women, adults under guardianship or guardianship, persons deprived of their liberty)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03313544
Contact: jennifer CAUTELA | 0491968289 | jennifer.cautela@ap-hm.fr | |
Contact: ALEXANDRA GIULIANI | 0491382747 | drci@ap-hm.fr |
France | |
Assistance Publique Hopitaux de Marseille | |
Marseille, France, 13354 | |
Contact: JENNIFER CAUTELA jennifer.cautela@ap-hm.fr | |
Principal Investigator: jennifer CAUTELA |
Study Director: | Jean-Olivier ARNAUD | assistance publique hôpitaux de marseille |
Responsible Party: | Assistance Publique Hopitaux De Marseille |
ClinicalTrials.gov Identifier: | NCT03313544 |
Other Study ID Numbers: |
2017-01 2017-001197-42 ( EudraCT Number ) |
First Posted: | October 18, 2017 Key Record Dates |
Last Update Posted: | October 18, 2017 |
Last Verified: | October 2017 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Melanoma Neuroendocrine Tumors Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal Neoplasms by Histologic Type Neoplasms |
Neoplasms, Nerve Tissue Nevi and Melanomas Nivolumab Antineoplastic Agents, Immunological Antineoplastic Agents |