Emergency Department Assessment of Right Ventricular Function and Size in the Post Cardiac Arrest Patient
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|ClinicalTrials.gov Identifier: NCT03309852|
Recruitment Status : Recruiting
First Posted : October 16, 2017
Last Update Posted : April 17, 2019
|Condition or disease|
|Right Ventricular Dysfunction Cardiac Arrest|
The use of point of care ultrasound (PoCUS) has grown rapidly. The incorporation of PoCUS in the assessment of patients in shock and to identify a reversible etiology to a patients cardiac arrest is widely practiced and endorsed by several organizations. While often overlooked, the right ventricle (RV) plays a critical role and often can provide clues to the etiology of a patient who is in shock. The right ventricle is very unique, as its anatomic structure, and function are markedly different then the left ventricle. What is often assessed is the size of the right ventricle. If dilated, which is defined as being >0.6 times that of the left ventricle, this could be indicative of elevated right sided pressures. In the right clinical context this may be caused by an acute pulmonary embolus. While this particular finding may raise clinical suspicion of acute right ventricular strain, point of care ultrasound cannot safely rule out acute pulmonary embolism. Several publications demonstrate the use of thrombolytics if a dilated RV is seen on PoCUS. This applies in patients with cardiac function who have not sustained a cardiac arrest. But in those patients who do sustain a cardiac arrest, these patients fall into a black hole of PoCUS findings related to the right ventricle. The international liaison committee on resuscitation has urged caution due to the unknown PoCUS findings during cardiac arrest. If one were to presume a dilated RV in a setting of a patient who sustained cardiac arrest was due to a pulmonary embolus, thrombolytics would be indicated. However, exposing the patient to thrombolytics, which in themselves carry a hemorrhage risk of 20%, is not a benign decision. Thus PoCUS findings as they pertain to the RV, in patient who sustain a cardiac arrest are unknown how they clinically correlate. Literature from critical care demonstrates that the right ventricle dilates, exhibits RV dysfunction, and carries a worse prognosis then that of the left ventricle. Recent animal data suggests that RV dilatation does occur in a porcine induced cardiac arrest model. To date, no human assessment of RV function and size in the immediate post-arrest state exists, and clearly a need to study this is evident.
objectives and hypothesis Objectives To assess the right ventricular function and size in patients who are immediately post-arrest patients.
Hypothesis Our hypothesis is that right ventricular dysfunction and dilatation is prevalent in the patients who are in cardiac arrest and in the post-cardiac arrest patient population, irrespective of they etiology of their cardiac arrest.
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||Emergency Department Assessment of Right Ventricular Function and Size in the Post Cardiac Arrest Patient|
|Actual Study Start Date :||October 6, 2017|
|Estimated Primary Completion Date :||October 5, 2020|
|Estimated Study Completion Date :||October 6, 2020|
- Right ventricular dysfunction [ Time Frame: 12 months ]Assessment of RV dysfunction in post cardiac arrest patients.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03309852
|Contact: Tomislav Jelic, MDemail@example.com|
|Health Sciences Centre||Recruiting|
|Winnipeg, Manitoba, Canada, R3A1R9|
|Contact: Tomislav Jelic, MD 2048990802 firstname.lastname@example.org|
|Principal Investigator:||Tomislav Jelic, MD||University of Manitoba, Health Sciences Centre|