Use of the Sit-To-Stand Task as a Screening Tool for Sarcopenia The
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|ClinicalTrials.gov Identifier: NCT03308903|
Recruitment Status : Recruiting
First Posted : October 13, 2017
Last Update Posted : October 10, 2018
A common condition associated with ageing is sarcopenia, which is a progressive decrease in muscle mass. Sarcopenia is associated with adverse outcomes including increased mortality, and places a major burden on healthcare spending, with the annual cost of sarcopenia in the United States exceeding that of osteoporosis and hip fracture. In the UK, the prevalence of sarcopenia in community-dwelling older people has been estimated at 5% for men and 8% for women. Current guidelines for sarcopenia diagnosis require muscle mass to be measured using costly devices such as Dual Energy X-ray Absorptiometry (DXA) and Magnetic Resonance Imaging (MRI). Previous research has found strong relationships between the sit-to-stand (STS) test and both muscle mass and muscle strength. This pilot study aims to examine this relationship in community-dwelling older people to develop predictive equations for initial screening of sarcopenia.
Forty subjects will be tested using the diagnostic criteria developed by the European Working Group on Sarcopenia in Older People (EWGSOP). Muscle mass will be measured using the DXA and diagnostic ultrasound. Muscle strength will be measured using isokinetic dynamometer, handgrip dynamometry, and hand-held dynamometry. Functional performance will be measured using the Timed-up-and-Go and gait velocity, and the STS. Subjects will perform two variants of the STS; the five times STS (5STS), which requires subjects to perform five consecutive STS movements as quick as possible, and the 30-second STS (30STS), which requires subjects to perform as many STS movements as possible in 30 seconds. All testing will be completed in a single session lasting 90 minutes for each subject. Testing will be performed at the University of Bedfordshire Polhill Campus. Subject recruitment will be recruited using advertisement posters and word of mouth.
|Condition or disease||Intervention/treatment|
|Sarcopenia||Diagnostic Test: DEXA scan|
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Official Title:||Can the Sit-to-Stand Test be Used as a Screening Tool to Detect Sarcopenia in Community-dwelling Older People?|
|Actual Study Start Date :||January 22, 2018|
|Estimated Primary Completion Date :||January 31, 2019|
|Estimated Study Completion Date :||March 31, 2019|
- Diagnostic Test: DEXA scan
The participant will undergo a whole-body DEXA (DEXA; GE Medical Systems, Chalfont St Giles, UK) scan, lasting approximately 5 minutes. This scan will produce body composition data, including estimates of lean body mass (LBM), appendicular lean mass (aLM) and body fat percentage (BF%).
- Muscle mass measurement using dual X-ray absorptiometry [ Time Frame: 5 minutes ]The participant will undergo a whole-body DEXA (DEXA; GE Medical Systems, Chalfont St Giles, UK) scan, lasting approximately 5 minutes. This scan will produce body composition data, including M and body fat percentage (BF%). For the purpose of this study, aLM values will be calculated in relation to height (sum of LBM in the arms and legs, scaled to height) (aLM/ht²).
- Hip and knee flexion and extension and ankle plantarflexion and dorsiflexion of both lower extremities on the Biodex System 3 Isokinetic Dynamometer [ Time Frame: 5 minutes ]Participants will perform two sets of five repetitions of hip and knee flexion and extension and ankle plantarflexion and dorsiflexion of both lower extremities on the Biodex System 3 Isokinetic Dynamometer (IKD) (Suffolk, UK), with a 2-minute rest period between sets. The angular velocity of the IKD will be set at 60º/s.
- Five times sit to stand test [ Time Frame: 5 minutes ]Participants will sit in a straight back chair with a solid seat that is 16" high. Participants will have their arms folded across their chest. They will then stand up and sit down as quickly as possible five times, keeping their arms folded across their chest. The test is measured with a stopwatch and is completed when the participant stands for the 5th time.
- Diagnostic ultrasound [ Time Frame: 5 minutes ]Sonographic estimates of LBM will be measured using a diagnostic ultrasound. Muscle thickness measurements will be taken from both arms and legs of the participants.
- Grip strength [ Time Frame: 5 minutes ]A measure of handgrip strength will be taken using the JAMAR PLUS + (Patterson Medical, IL, USA) of both the participant's upper extremities. Measures will be taken twice with a 2-minute rest period between trials. This requires the participant to exert their maximal grip in an isometric contraction.
- Handheld dynamometer assessment of muscle strength [ Time Frame: 5 minutes ]Measures of isometric muscle strength will be measured using the hand-held dynamometer (HHD). Measures will be taken from the hip flexors, quadriceps, hamstrings, gastroc-soleus complex and tibialis anterior of both lower extremities.
- Timed Up and Go test [ Time Frame: 2 minutes ]
The participant sits on a standard armchair, placing his/her back against the chair and resting his/her arms chair's arms. The participant is instructed to use a comfortable and safe walking speed. The participant walks to a line that is 3 meters away, turns around at the line, walks back to the chair, and sits down. The test ends when the patient's buttocks touch the seat.
A stopwatch is used to time the test (in seconds).
- 30-second sit to stand test [ Time Frame: 5 minutes ]Participants will sit in a straight back chair with a solid seat that is 16" high. Participants will have their arms folded across their chest. They will then stand up and sit down as quickly as possible for 30 seconds, keeping their arms folded across their chest. The test is measured with a stopwatch and is completed after 30 seconds, with the number of completed sit to stands taken as the score.
- Gait velocity [ Time Frame: 2 minutes ]Participants will be asked to walk at a comfortable pace between two lines, marked five metres apart. The time taken will be measured with a stopwatch, with total time taken as the score.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03308903
|Contact: David Hewson, PhD||0044 firstname.lastname@example.org|
|Contact: Daniel Bailey, PhD||0044 email@example.com|
|University of Bedfordshire||Recruiting|
|Bedford, Bedfordshire, United Kingdom, MK41 9EA|
|Contact: David Hewson, PhD 0044 7525 616645 firstname.lastname@example.org|