Isolation and Establishment of Gustatory Cell Lines in Patients Operated on for Cancer of the Mobile Tongue - ImmortTasteCELL
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|ClinicalTrials.gov Identifier: NCT03305302|
Recruitment Status : Completed
First Posted : October 9, 2017
Last Update Posted : September 15, 2020
In terms of incidence, cancer of the tongue is one of the leading cancers in France. Moreover, this cancer is associated with physiological complications ranging from swallowing disorders to loss of taste. Following surgery, impaired perception of food taste may lead to cachexia. It is therefore necessary to carry out research in the field of impaired taste, notably with regard to the regeneration of taste buds. However, there is currently no available functional model of taste bud cells.
It is therefore necessary to obtain a cell line of human taste cells. These immortalised human cells will allow us to better orient our investigations for applications in humans: search for and characterisation of "taste modifiers" synthesised using organic chemistry, able to trigger the perception of food in cases of taste loss or taste impairment.
Moreover, given recent studies conducted by the investigating team proposing the existence of a fatty taste and its implication in obesity, the work of the team could be oriented towards the synthesis of lipid-receptor agonists, by analogy with artificial sweeteners instead of sugar. The availability of these chemical molecules would lead to a reduction in lipid intake as these agents contain no (or very few) calories. They will act as an organoleptic decoy.
|Condition or disease||Intervention/treatment|
|Cancer of the Tongue||Procedure: Sample of cancerous epithelium from the tongue|
|Study Type :||Observational|
|Actual Enrollment :||50 participants|
|Official Title:||Isolation and Establishment of Gustatory Cell Lines in Patients Operated on for Cancer of the Mobile Tongue - ImmortTasteCELL|
|Actual Study Start Date :||November 2, 2017|
|Actual Primary Completion Date :||April 1, 2018|
|Actual Study Completion Date :||April 1, 2018|
- Procedure: Sample of cancerous epithelium from the tongue
Harvesting and culture of cancerous epithelium from the surgical piece
- Immortalised human taste bud cells, isolated from the fungiform tastebuds of patients with cancer of the mobile tongue. [ Time Frame: through study completion, an average of 1 year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03305302
|Chu Dijon Bourgogne|
|Dijon, France, 21000|