Study the Effect of Probiotics Combined With Bismuth Quadruple Rescue Therapy on H Pylori Infective Patients
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|ClinicalTrials.gov Identifier: NCT03297242|
Recruitment Status : Not yet recruiting
First Posted : September 29, 2017
Last Update Posted : December 7, 2017
|Condition or disease|
|Helicobacter Pylori Infection|
H pylori infection rate has been up to half of the world population. H pylori infection is associated with various diseases, especially gastric cancer.
With the increasingly resistant to antibiotics,the eradication rate has decreased a lot with traditional triple therapy. Exploring a valid scheem for patients who have failed multiple times is important.
Probiotics can improve gastrointestinal microenvironment, then release the adverse effects during the eradication process.Additionally,there is also a lot evidence that probiotics can inhibit H plori，but still controversially.
There is a low resistant rate about furazolidone and tetracycline. In this study investigators observe the efficacy of the therapy 2w's compound lactobacillus acidophilus followed by 10d's bismuth, furazolidone, tetracycline contained quadruple scheme on patients who have failed more than 2 times. 4 to 6 weeks after the therapy, if Urea Breath Test (UBT) is nedative which means eradicating H plori successfully.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||A Retrospective Study of the Efficacy of Compound Lactobacillus Acidophilus Combined With Bismuth Quadruple Rescue Therapy on Patients With H Pylori Eradication Failures|
|Estimated Study Start Date :||December 2017|
|Estimated Primary Completion Date :||September 2018|
|Estimated Study Completion Date :||September 2018|
- urea breath test [ Time Frame: 4-6 weeks after the quadruple therapy ]if urea breath test is negative,it means H pylori eradicated successfully
- adverse effects [ Time Frame: 1month ]adverse effects mean the new symptoms during the treatment process,such as nausea,vomiting.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03297242
|Contact: Yi Q Du, MDemail@example.com|
|Contact: Ai R Liu, MMfirstname.lastname@example.org|
|Principal Investigator:||Zhao S Li, MD|