We're building a better ClinicalTrials.gov. Check it out and tell us what you think!
Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

Cohort Study in South China

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03288805
Recruitment Status : Active, not recruiting
First Posted : September 20, 2017
Last Update Posted : May 5, 2022
Sponsor:
Collaborators:
Guangxi Medical University
Hainan Medical College
Guangzhou No.12 People's Hospital
Fujian Medical University
The First Affiliated Hospital of Xiamen University
Shenzhen Fifth People's Hospital
Guangzhou Medical University
Information provided by (Responsible Party):
Min Xia, Sun Yat-sen University

Brief Summary:
Healthy Chinese residents from South China will be recruited and followed up for at least 4 years to evaluate the association between climate, diet and lifestyle and risks for the development of chronic diseases. Physical examination, questionnaire survey and biological sample collection will be conducted at baseline and the incidence of chronic diseases will be investigated during follow-up.

Condition or disease
Chronic Disease

Detailed Description:
110,000 adult Chinese (35 to 74 years old) without chronic diseases and major disability who have been living in South China including Guangdong, Fujian, Guangxi and Hainan for more than 5 years will be recruited. All participants will be prospectively followed up for the incidence of chronic diseases (stroke, coronary heart disease, malignant neoplasms, chronic obstructive pulmonary diseases, diabetes and hypertension) and their risk factors (impaired glucose tolerance and obesity). Information about socio-demographic, diet, lifestyle, psychological status, medical history and current medication will be collected by questionnaires. Physical examinations including height, weight, waist and hip circumferences, blood pressure, fat mass and vital capacity will be conducted. Besides, blood, urine and fecal samples will be collected for further analysis. Annual meteorological data throughout the study period will also be collected. The associations between climate, diet and lifestyle and risks for chronic diseases will be evaluated.

Layout table for study information
Study Type : Observational
Estimated Enrollment : 110000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Cohort Study of Chronic Diseases in South China
Actual Study Start Date : January 1, 2017
Estimated Primary Completion Date : December 31, 2030
Estimated Study Completion Date : December 31, 2030





Primary Outcome Measures :
  1. Incidence of chronic disease [ Time Frame: 4 years ]
    Incidence of chronic disease, including stroke, coronary heart disease, cancer, chronic obstructive pulmonary disease, diabetes and hypertension


Secondary Outcome Measures :
  1. Risk factors for chronic diseases [ Time Frame: 4 years ]
    Incidence of impaired glucose tolerance and obesity


Biospecimen Retention:   Samples With DNA
Serum ,Urine and fecal samples for biochemical tests, biomarker examination and DNA extraction


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   35 Years to 74 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adult Chinese (35-74 years old) who have been living in South China including Guangdong, Fujian, Guangxi and Hainan provinces for more than 5 years.
Criteria

Inclusion Criteria:

  • adult Chinese (35-74 years old) who have been living in South China including Guangdong, Fujian, Guangxi and Hainan provinces for more than 5 years.

Exclusion Criteria:

  • any subject diagnosed with stroke, coronary heart disease, malignancy, chronic obstructive pulmonary disease, diabetes and hypertension.
  • any subject who suffer from major disability and cannot participate in the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03288805


Locations
Layout table for location information
China, Guangdong
Sun Yat-Sen University
Guangzhou, Guangdong, China, 510080
Sponsors and Collaborators
Min Xia
Guangxi Medical University
Hainan Medical College
Guangzhou No.12 People's Hospital
Fujian Medical University
The First Affiliated Hospital of Xiamen University
Shenzhen Fifth People's Hospital
Guangzhou Medical University
Investigators
Layout table for investigator information
Principal Investigator: Min Xia School of Public Health,Nutrition and Food Hygiene,Sun Yat-sen University
Layout table for additonal information
Responsible Party: Min Xia, Professor, Sun Yat-sen University
ClinicalTrials.gov Identifier: NCT03288805    
Other Study ID Numbers: 2017YFC0907100
First Posted: September 20, 2017    Key Record Dates
Last Update Posted: May 5, 2022
Last Verified: May 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
Layout table for MeSH terms
Chronic Disease
Disease Attributes
Pathologic Processes