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Trial record 89 of 10364 for:    strength

Cardiovascular Effects of Aerobic and Strength Training in Hypertensive Middle-aged Individuals

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03282942
Recruitment Status : Completed
First Posted : September 14, 2017
Last Update Posted : September 26, 2019
Information provided by (Responsible Party):
Alvaro Reischak-Oliveira, Federal University of Rio Grande do Sul

Brief Summary:
Systemic arterial hypertension (SAH) is characterized by elevated and sustained blood pressure levels, related to several risk factors. Modifying lifestyle to combat risk factors associated with cardiovascular disease is critical, as such factors are related alteration of endothelial vasodilator response leading to progressive loss of its protective function. However, endothelial dysfunction related to hypertension is not only related to the decrease in the bioavailability of endothelium relaxants, but also to the time of presence of hypertension, increased production of vessel contraction factors and oxidative stress related to the disease. In this way, physical training presents as a non-drug strategy capable of directly and indirectly influencing the pathophysiology of hypertension. In this way the objective of the present work will be to evaluate the acute and chronic effect of aerobic exercise and strength on blood pressure, blood markers of vasodilation and vascular endothelial vasoconstriction, as well as the repercussion on flow-mediated dilatation and oxidative stress markers, In middle-aged hypertensive individuals before and after 12 weeks of training. Study hypothesis: The expected results of the research are that the endothelial response of biochemical markers of vasodilation and vasoconstriction will change positively after aerobic and strength training and the responses will be similar when compared between groups. There will be an improvement in the antioxidant capacity in both groups and the magnitude of the hypotensive effect will be greater in the aerobic group when compared to control and strength.

Condition or disease Intervention/treatment Phase
Arterial Hypertension Other: Strength training group Other: Aerobic Training Group Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effects of Aerobic or Strength Training on Cardiovascular, Endothelial Response, and Blood Flow in Hypertensive Middle Ages Individuals: a Randomized Controlled Clinical Trial.
Actual Study Start Date : June 2, 2018
Actual Primary Completion Date : June 30, 2019
Actual Study Completion Date : July 30, 2019

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Exercise training protocols
Participants will be randomized in one of TWO groups: aerobic training group (AT) or strength training group (ST). Each training protocol will last 12 weeks, being the initial two weeks designed to participants' gradual adaptations to respective training protocol, with sessions performed three times per week in non-consecutive days.
Other: Strength training group

Individuals in the strength training group will perform exercises based on exercises with free weights and equipment, for upper and lower limbs with a weekly frequency of three times for twelve weeks. The periodization will start with 2 sets, 15 - 20 repetitions, passive rest of 120 seconds, exercises performed alternating by segments and the intensity of 50% of maximum repetition. After twelve weeks the periodization will be finished with 3 sets, 8-12 repetitions, passive rest of 120 seconds, exercises performed alternated by segments and the intensity of 70% of maximum repetition.

The following exercises will compose the strength training protocol:

  • Squatting
  • Leg press
  • Knee Extension
  • Knee Flexion
  • Supine Challenge
  • High Pull
  • Elbow flexion
  • Extension of elbows
  • Development
  • Abdominal

Other: Aerobic Training Group
Individuals in the aerobic training group will perform aerobic treadmill exercise three times a week for twelve weeks. The training prescription will be performed through the percentage of maximum oxygen consumption with intensity in 60% to 80% with an average duration of 50 minutes of continuous exercise.

No Intervention: Control Group
The individuals who will be part of the control group will be instructed to follow their daily activities, avoiding any systematic exercise program and return to the end of the 12 weeks for reevaluation.

Primary Outcome Measures :
  1. Blood pressure [ Time Frame: End of 12-week exercise period ]
    24-h Ambulatory blood pressure

  2. Endothelial Function [ Time Frame: End of 12-week exercise period ]
    Flow mediated dilation to reactive hyperemia

  3. Endothelium derived factors [ Time Frame: End of 12-week exercise period ]
    The plasma levels of NOx and ET-1 will be determined by enzyme-linked immunosorbent assay

  4. Inflammatory Profile [ Time Frame: End of 12-week exercise period ]
    The inflammatory profile was accessed trough the cytokines and chemokines levels

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Ages Eligible for Study:   30 Years to 59 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Study inclusion criteria consisted of the following: 1) Individuals should use antihypertensive medication; 2) 30-59 years of age.

Exclusion Criteria:

The following aspects were regarded as exclusion criteria: 1) body mass index (BMI) up to 40 kg/m2; 2) regular engagement in any type of physical exercise training in the past 6 months prior to inclusion in the study; 3) symptomatic peripheral arterial occlusive disease; 4) aortic insufficiency or stenosis more than stage I; 5) hypertrophic obstructive cardiomyopathy; 6) congestive heart failure (>NYHA II); 7) uncontrolled cardiac arrhythmia with hemodynamic relevance; 7) change of antihypertensive medication in the past 4 weeks prior to inclusion in the study; 8) indication of unstable coronary artery disease. 9) use of tobacco products.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03282942

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Universidade Federal do Rio Grande do Sul
Porto Alegre, Rio Grande Do Sul, Brazil
Sponsors and Collaborators
Federal University of Rio Grande do Sul
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Principal Investigator: Alvaro Reischak-Oliveira, PhD Federal University of Rio Grande do Sul

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Responsible Party: Alvaro Reischak-Oliveira, Principal Investigator, Federal University of Rio Grande do Sul Identifier: NCT03282942     History of Changes
Other Study ID Numbers: 69373217.3.0000.5347
First Posted: September 14, 2017    Key Record Dates
Last Update Posted: September 26, 2019
Last Verified: September 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Alvaro Reischak-Oliveira, Federal University of Rio Grande do Sul:
Aerobic training
Strength training
Additional relevant MeSH terms:
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Vascular Diseases
Cardiovascular Diseases