Cardiovascular Effects of Aerobic and Strength Training in Hypertensive Middle-aged Individuals
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|ClinicalTrials.gov Identifier: NCT03282942|
Recruitment Status : Completed
First Posted : September 14, 2017
Last Update Posted : September 26, 2019
|Condition or disease||Intervention/treatment||Phase|
|Arterial Hypertension||Other: Strength training group Other: Aerobic Training Group||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||60 participants|
|Intervention Model:||Factorial Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Effects of Aerobic or Strength Training on Cardiovascular, Endothelial Response, and Blood Flow in Hypertensive Middle Ages Individuals: a Randomized Controlled Clinical Trial.|
|Actual Study Start Date :||June 2, 2018|
|Actual Primary Completion Date :||June 30, 2019|
|Actual Study Completion Date :||July 30, 2019|
Experimental: Exercise training protocols
Participants will be randomized in one of TWO groups: aerobic training group (AT) or strength training group (ST). Each training protocol will last 12 weeks, being the initial two weeks designed to participants' gradual adaptations to respective training protocol, with sessions performed three times per week in non-consecutive days.
Other: Strength training group
Individuals in the strength training group will perform exercises based on exercises with free weights and equipment, for upper and lower limbs with a weekly frequency of three times for twelve weeks. The periodization will start with 2 sets, 15 - 20 repetitions, passive rest of 120 seconds, exercises performed alternating by segments and the intensity of 50% of maximum repetition. After twelve weeks the periodization will be finished with 3 sets, 8-12 repetitions, passive rest of 120 seconds, exercises performed alternated by segments and the intensity of 70% of maximum repetition.
The following exercises will compose the strength training protocol:
Other: Aerobic Training Group
Individuals in the aerobic training group will perform aerobic treadmill exercise three times a week for twelve weeks. The training prescription will be performed through the percentage of maximum oxygen consumption with intensity in 60% to 80% with an average duration of 50 minutes of continuous exercise.
No Intervention: Control Group
The individuals who will be part of the control group will be instructed to follow their daily activities, avoiding any systematic exercise program and return to the end of the 12 weeks for reevaluation.
- Blood pressure [ Time Frame: End of 12-week exercise period ]24-h Ambulatory blood pressure
- Endothelial Function [ Time Frame: End of 12-week exercise period ]Flow mediated dilation to reactive hyperemia
- Endothelium derived factors [ Time Frame: End of 12-week exercise period ]The plasma levels of NOx and ET-1 will be determined by enzyme-linked immunosorbent assay
- Inflammatory Profile [ Time Frame: End of 12-week exercise period ]The inflammatory profile was accessed trough the cytokines and chemokines levels
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03282942
|Universidade Federal do Rio Grande do Sul|
|Porto Alegre, Rio Grande Do Sul, Brazil|
|Principal Investigator:||Alvaro Reischak-Oliveira, PhD||Federal University of Rio Grande do Sul|