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Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight

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ClinicalTrials.gov Identifier: NCT03281512
Recruitment Status : Completed
First Posted : September 13, 2017
Last Update Posted : September 13, 2017
Sponsor:
Collaborator:
National Institute of Health and Nutrition
Information provided by (Responsible Party):
Jingjing Jiao, Zhejiang University

Brief Summary:
The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The investigators aim to use the data from the China Health and Nutrition Survey to assess the long-term association of SFAs intake with total mortality, diabetes, hypertension and overweight.

Condition or disease
Morality Diabetes Hypertension Overweight

Detailed Description:
The role of saturated fatty acids (SFAs) intake in the development of total death, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is lacking.The investigators aim to utilize the data from the China Health and Nutrition Survey. The investigators will calculate the cumulative average intake of SFAs based on 3 consecutive 24-h dietary recalls in each round.Sex-specific Cox regression models will be used to estimate the relative risk.Results from our work will be used to provide epidemiological evidence for improving recommendation on SFAs intake for Chinese in dietary guidelines.

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Study Type : Observational
Actual Enrollment : 14383 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight in the China Health and Nutrition Survey (CHNS)
Actual Study Start Date : January 1, 1989
Actual Primary Completion Date : December 31, 2011
Actual Study Completion Date : December 31, 2012

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Mortality [ Time Frame: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years ]
    Incidence of all-cause death, on basis of household members' report

  2. Diabetes [ Time Frame: From entry into the study (baseline: 1997-2009) until 2011 ]
    Incidence of diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%


Secondary Outcome Measures :
  1. Saturated fatty acids intake [ Time Frame: From entry into the study (baseline: 1997-2009) until 2011 ]
    Cumulative average intake of saturated fatty acids on basis of 3 consecutive 24-h dietary recalls

  2. Hypertension [ Time Frame: From entry into the study (baseline: 1997-2009) until 2011 ]
    Incidence of hypertension, on basis of self-reported physician diagnosis, systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg

  3. Overweight [ Time Frame: From entry into the study (baseline: 1997-2009) until 2011 ]
    Incidence of overweight, on basis of body mass index (BMI), BMI ≥ 24 kg/㎡



Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population.
Criteria

Inclusion Criteria:

  • Adults aged ≥20 with complete data on diet and follow-up time

Exclusion Criteria:

  • Cardiovascular diseases
  • Diabetes (for analyses of diabetes)
  • Body mass index ≥ 24 kg/㎡ (for analyses of overweight)
  • Hypertension (for analyses of hypertension)
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Jingjing Jiao, Associate Professor, Zhejiang University
ClinicalTrials.gov Identifier: NCT03281512    
Other Study ID Numbers: Cohort_SFA
First Posted: September 13, 2017    Key Record Dates
Last Update Posted: September 13, 2017
Last Verified: September 2017

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Jingjing Jiao, Zhejiang University:
Saturated fatty acids
CHNS
Additional relevant MeSH terms:
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Hypertension
Diabetes Mellitus
Overweight
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Vascular Diseases
Cardiovascular Diseases
Body Weight
Signs and Symptoms