A Prospective Study of Evaluation of Minor Bleeding and Utility of Bleeding Criteria in Acute-on-chronic Liver Failure Patients in China
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ClinicalTrials.gov Identifier: NCT03281252
Recruitment Status : Unknown
Verified July 2017 by Nanfang Hospital of Southern Medical University. Recruitment status was: Recruiting
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. However, the minor and major bleeding events has not been described yet. We observe the patients' major and minor bleeding events and use 4 criteria, which include BARC, ISTH, TIMI, Gusto ,to evaluate the incident rate of bleeding events in ACLF patients and pre-ACLF patients.
Condition or disease
Liver Failure, Acute on ChronicHemostatic Disorder
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
pre-acute-on-chronic liver failure and acute-on-chronic liver failure
patient with previously or undiagnosed chronic liver disease/cirrhosis;
serum bilirubin higher than 3 mg/dl (51 mmol/L) or ALT>10ULN（male 300 U/L; female 200 U/L)
those who had or been diagnosed hepatocellular carcinoma or other types of malignancies;
obstructive biliary diseases or other disease lead to bilirubin evaluation;
using steroid or immunosuppressant in 4 weeks;
prior surgeries including splenectomy，subtotal splenectomy and disconnection，liver transplantation.
combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS<8)