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How Many Days Would You Want to Practice a Skill to Achieve it?

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03249961
Recruitment Status : Active, not recruiting
First Posted : August 15, 2017
Last Update Posted : June 4, 2020
Sponsor:
Information provided by (Responsible Party):
Sunnybrook Health Sciences Centre

Brief Summary:
Practice is required to improve your shot in basketball or to play a musical instrument. The learning of these motor skills can be further enhanced by non-invasively stimulating regions of the brain that control movements with electrical currents. These electric currents can strengthen or weaken connections of the brain, which consequently affects a person's ability to improve their performance on a skill. Non-invasive brain stimulation (NIBS) is widely applied in many disciplines of neuroscience research, and has potential therapeutic application. There are two specific types of NIBS that will be used in this research study: 1) Transcranial Direct Current Stimulation (tDCS), which applies very weak electrical currents via two rubber electrodes on the scalp, and 2) Transcranial Magnetic Stimulation (TMS), which applies magnetic pulses via a coil against the head, to stimulate regions of the brain. Both types of non-invasive brain stimulation (i.e., tDCS, and TMS) are well-tolerated, painless, and safe. The application of tDCS to brain regions that control movements, concurrently with practice of a skill, results in better skill performance, than practice alone with no tDCS. Therefore, in this study, we will be testing different types of brain stimulation and different amounts of practice.

Condition or disease Intervention/treatment Phase
Motor Learning Device: Sham TDCS Device: Anodal TDCS Device: Transcranial Magnetic Stimulation (TMS) Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 27 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: How Many Days Would You Want to Practice a Skill to Achieve it?
Actual Study Start Date : April 20, 2018
Estimated Primary Completion Date : August 2020
Estimated Study Completion Date : August 2020

Arm Intervention/treatment
Experimental: Placebo Brain stimulation
Participants will receive Sham TDCS, and Transcranial Magnetic Stimulation (TMS)
Device: Sham TDCS
Placebo stimulation is applied to the left motor cortex while participants perform a motor task in the right hand. During the motor task, participants use their right hand to pinch a force transducer that controls an on-screen cursor to navigate between a start position and a sequence of 5 other positions to the right.

Device: Transcranial Magnetic Stimulation (TMS)
Participants will receive Transcranial Magnetic Stimulation (TMS) to allow research investigators to determine the location of the left motor cortex.

Experimental: Excitatory Brain Stimulation
Participants will receive Anodal TDCS, and Transcranial Magnetic Stimulation (TMS)
Device: Anodal TDCS
Excitatory stimulation is applied to the left motor cortex while participants perform a motor task in the right hand. During the motor task, participants use their right hand to pinch a force transducer that controls an on-screen cursor to navigate between a start position and a sequence of 5 other positions to the right.

Device: Transcranial Magnetic Stimulation (TMS)
Participants will receive Transcranial Magnetic Stimulation (TMS) to allow research investigators to determine the location of the left motor cortex.




Primary Outcome Measures :
  1. Accuracy [ Time Frame: Up to 8 days ]
    Accuracy is defined as the proportion of trials per block with hits to all targets in the correct sequence order.

  2. Speed [ Time Frame: Up to 8 days ]
    Speed is captured by the average sequence movement time per training block



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 44 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy

Exclusion Criteria:

  • prior history of neurological or psychiatric disease
  • prior experience with the motor task used
  • contraindications to TMS and TDCS (e.g., metal implants, history of seizures and headaches)
  • musculoskeletal injury to upper limb
  • drugs that interact with NIBS (e.g., antidepressants, antipsychotics, anticonvulsants)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03249961


Locations
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Canada, Ontario
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
Sunnybrook Health Sciences Centre
Investigators
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Principal Investigator: Joyce Chen, PhD Sunnybrook Research Institute
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Responsible Party: Sunnybrook Health Sciences Centre
ClinicalTrials.gov Identifier: NCT03249961    
Other Study ID Numbers: 175-2017
First Posted: August 15, 2017    Key Record Dates
Last Update Posted: June 4, 2020
Last Verified: June 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Sunnybrook Health Sciences Centre:
motor
transcranial direct current stimulation
transcranial magnetic stimulation