Cardiovascular Comorbidity in Children With Chronic Kidney Disease
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|ClinicalTrials.gov Identifier: NCT03227055|
Recruitment Status : Unknown
Verified July 2017 by Tain, You-Lin, Chang Gung Memorial Hospital.
Recruitment status was: Recruiting
First Posted : July 24, 2017
Last Update Posted : July 24, 2017
|Condition or disease|
|Childhood Chronic Kidney Disease|
Taiwan has the highest incidence and prevalence rates of end-stage renal disease all over the world. Chronic kidney disease (CKD) becomes a global public health burden, which can begin in earliest childhood. CKD in childhood differs from that in adults. Congenital anomalies of the kidney and urinary tract (CAKUT) is the leading cause of childhood CKD. Children with CKD due to CAKUT have the highest risk of having a genomic imbalance. Thus, early identification of genotype-phenotype correlations to develop novel therapeutic approaches might reduce the heavy burden of CKD for the future of Taiwan.
- A 3-year prospective cohort study.
- Sample size: 125 children and adolescents with stage G1-G4 CKD, age 3 to 18 yr, and 30 controls.
4. Measurement: Measurements of morphological (e.g., LVMI & cIMT) and functional characteristics (e.g., FMD & PWV) of the cardiovascular system and 24hr ABPM profile will serve as surrogate end points for CV comorbidity in this study. Possible associations of these end points with multiple molecular (ADMA & urine exosome miRNA), perceived value and behavior (EQ-5D-Y), pharmacological (NHIRD and CGRD), and environmental risk factors (patient and family survey) will be explored.
|Study Type :||Observational|
|Estimated Enrollment :||155 participants|
|Official Title:||Cardiovascular Comorbidity in Children With Chronic Kidney Disease: Identification of Novel Biomarkers and Therapeutic Targets|
|Actual Study Start Date :||December 30, 2016|
|Estimated Primary Completion Date :||December 31, 2019|
|Estimated Study Completion Date :||December 31, 2019|
Children and adolescents with stage G1-G4 CKD, age 3 to 18 yr
- Hypertension [ Time Frame: 1 year ]Abnormal ABPM profile
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03227055
|Contact: You-Lin Tain, MD, PhD||+886-7-7317123 ext firstname.lastname@example.org|
|Contact: Chien-Ning Hsu, PhD||+886-7-7317123 ext email@example.com|
|Kaohsiung Chang Gung Memorial Hospital||Recruiting|
|Kaohsiung, Taiwan, 833|
|Contact: You-Lin Tain, MD, PhD firstname.lastname@example.org|