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Trial record 92 of 326 for:    clonidine

Comparison Between Epinephrine and Clonidine as Adjuvants to Lidocaine in Axillary Brachial Plexus Block.

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ClinicalTrials.gov Identifier: NCT03207022
Recruitment Status : Completed
First Posted : July 2, 2017
Last Update Posted : July 2, 2017
Sponsor:
Information provided by (Responsible Party):
Dr Anil Ranganath, Cork University Hospital

Brief Summary:

Adjuncts to local anaesthetics for the peripheral nerve blocks such as epinephrine, clonidine and opioids have been widely used to enhance quality, duration of anaesthesia and postoperative analgesia. Clonidine, an α2-adrenergic agonist, when combined with local anaesthetics in axillary brachial plexus block has shown to decrease block onset time and prolong the duration of anaesthesia.

We propose to compare the effects of combining both adjuvants to 20 mL of lidocaine 2% on the onset of ultrasound guided axillary brachial plexus block.


Condition or disease Intervention/treatment Phase
Brachial Plexus Blockade Procedure: axillary brachial plexus block Not Applicable

  Show Detailed Description

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Other
Official Title: Comparison Between Epinephrine and Clonidine as Adjuvants to Lidocaine in Ultrasound Guided Axillary Brachial Plexus Block.
Actual Study Start Date : June 11, 2014
Actual Primary Completion Date : July 14, 2016
Actual Study Completion Date : July 14, 2016


Arm Intervention/treatment
Active Comparator: lidocaine 2% with normal saline
Patients will receive ultrasound guided axillary brachial plexus block with 20 ml of lidocaine 2% with epinephrine mixed with 2 ml of 0.9% normal saline.
Procedure: axillary brachial plexus block
ultrasound guided axillary brachial plexus block with 20 ml local anaesthetic lidocaine with epinephrine and clonidine

Experimental: lidocaine 2% with clonidine
Patients will receive ultrasound guided axillary brachial plexus block with 20 ml of lidocaine 2% with epinephrine mixed with clonidine 1µg/kg in 2 ml of 0.9% normal saline.
Procedure: axillary brachial plexus block
ultrasound guided axillary brachial plexus block with 20 ml local anaesthetic lidocaine with epinephrine and clonidine




Primary Outcome Measures :
  1. onset of sensory block [ Time Frame: 1 day ]
    time taken for onset of Ultrasound guided axillary brachial plexus block


Secondary Outcome Measures :
  1. Onset of motor block. [ Time Frame: 1 day ]
    time taken for onset of motor block of ultrasound guided axillary brachial plexus block

  2. Duration of sensory and motor block [ Time Frame: 1 day ]
    Total duration of sensory block of ultrasound guided axillary brachial plexus block

  3. Duration of motor block [ Time Frame: 1 day ]
    Total duration of motor block of ultrasound guided axillary brachial plexus block

  4. Adverse effect perioperatively [ Time Frame: 1 day ]
    The incidence of side effects in both groups. : sedation, hypotension, nausea, us, vomiting convulsions or arrythmia



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ASA 1-2
  • Patients age >18 years
  • Undergoing elective upper limb (forearm, wrist or hand) surgery.

Exclusion Criteria:

  • Contraindications to regional anaesthesia
  • Hypersensitivity to amide local anaesthetics.
  • Chronic pain
  • Language barrier
  • Neuromuscular disorders or peripheral neuropathy
  • H/o postural hypotension or autonomic dysfunction.
  • Patients with a known sensitivity for local anaesthetics
  • Body mass index > 35
  • History of hepatic and renal insufficiency
  • Pregnancy
  • Cognitive or psychiatric disorder
  • Cardiac conduction abnormality.
  • Anti arrythmic or adrenergic medications.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03207022


Sponsors and Collaborators
Cork University Hospital
Investigators
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Principal Investigator: Anil Ranganath Cork University Hospital

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Responsible Party: Dr Anil Ranganath, Dr (Fellow in Regional Anaesthesia), Cork University Hospital
ClinicalTrials.gov Identifier: NCT03207022     History of Changes
Other Study ID Numbers: ECM 4 (aa)
First Posted: July 2, 2017    Key Record Dates
Last Update Posted: July 2, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Clonidine
Lidocaine
Epinephrine
Racepinephrine
Epinephryl borate
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Anti-Arrhythmia Agents
Voltage-Gated Sodium Channel Blockers
Sodium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Anti-Asthmatic Agents
Respiratory System Agents
Mydriatics
Sympathomimetics
Vasoconstrictor Agents
Analgesics
Antihypertensive Agents