The Effect of Daily Mango Intake on Cardiovascular Health
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03203187|
Recruitment Status : Recruiting
First Posted : June 29, 2017
Last Update Posted : August 5, 2021
In the current proposal the investigators seek to evaluate the acute and short-term effects of mango intake on vascular and platelet function in postmenopausal women between 50 and 70 years old.
Our aims are 1) to determine if two weeks of daily mango intake will result in favorable changes in measures of vascular function, as measured using peripheral arterial tonometry (PAT) and platelet reactivity, in overweight and obese postmenopausal women. 2) to determine if two weeks of daily mango intake will change the fermentation capacity of gut microbiota.
Investigators hypothesize that the daily intake of 330 grams of mango (2 cups) will significantly increase PAT while reducing platelet aggregation after 2 hours and two weeks of daily intake.
|Condition or disease||Intervention/treatment||Phase|
|Cardiovascular Risk Factor||Other: Mango Other: No intervention||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||25 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Daily Mango Intake (Mangifera Indica L.) on Cardiovascular Health|
|Actual Study Start Date :||October 2, 2016|
|Estimated Primary Completion Date :||July 14, 2026|
|Estimated Study Completion Date :||August 14, 2026|
Placebo Comparator: No mango intake
No mango intake for two weeks
Other: No intervention
No mango intake for two weeks.
Experimental: 330 grams of daily mango intake
330 grams (2 cups) of daily mango intake for two weeks
330 grams (2 cups) of daily mango intake for two weeks, one cup in the morning, the other in the evening
- Acute vascular function [ Time Frame: change from baseline to 2 hours compared on days 0 14 and 28 ]Comparison of the effect of mango on acute vascular function between baseline and 2-hour postprandial response using PAT.
- Long-term vascular function [ Time Frame: Comparison of day 0, 14, and 28 ]The effect of mango on long-term vascular function between baseline, two week, and four week time points using PAT
- Acute platelet aggregation [ Time Frame: change from baseline to 2 hours compared on days 0 14 and 28 ]Comparison of the effect of mango on acute platelet aggregation between baseline and 2-hour postprandial time.
- Long-term platelet aggregation [ Time Frame: Comparison of day 0, 14, and 28 ]Comparison of the effect of mango on long-term platelet aggregation baseline, two week, and four week time points.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03203187
|Contact: Robert Hackman, PhDfirstname.lastname@example.org|
|United States, California|
|Regal Human Nutrition Research Center||Recruiting|
|Davis, California, United States, 95616|
|Contact: Xiang Li 530-761-8971 email@example.com|