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Catestatin and Hypertension in Pregnancy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03200743
Recruitment Status : Unknown
Verified June 2017 by Yuchen Pan, Peking University Third Hospital.
Recruitment status was:  Recruiting
First Posted : June 27, 2017
Last Update Posted : June 27, 2017
Information provided by (Responsible Party):
Yuchen Pan, Peking University Third Hospital

Brief Summary:
Catestatin is a kind of protein involved with cardiovascular disease. Accumulated evidence shows that Catestatin may be a predictor of primary hypertension, but whether it plays the same role in pregnant hypertensive disorders needs to be determined. By measuring the plasma level of Catestatin, main biochemical marks and UCG in healthy pregnancy and pregnancy with hypertension, the research may contribute to this problem.

Condition or disease
Pre-Eclampsia Eclampsia Hypertension, Pregnancy-Induced Hypertension in Pregnancy

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Study Type : Observational [Patient Registry]
Estimated Enrollment : 400 participants
Observational Model: Case-Control
Time Perspective: Prospective
Target Follow-Up Duration: 18 Years
Official Title: Relationship Between Catestatin and Pregnant Hypertensive Disorders
Actual Study Start Date : May 14, 2017
Estimated Primary Completion Date : December 2017
Estimated Study Completion Date : December 2017

Resource links provided by the National Library of Medicine


Primary Outcome Measures :
  1. plasma level of Catestatin [ Time Frame: once at the specified enrollment period ]
    plasma level of Catestatin with the unit "mmol/l"

Secondary Outcome Measures :
  1. blood pressure [ Time Frame: the specified enrollment period,42 days and 2 months after the pregnancy ]
    systolic and diastolic blood pressure with the unit "mmHg"

Biospecimen Retention:   None Retained

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients hospitalized in Peking University Third Hospital maternity ward after May, 2017

Inclusion Criteria:

  • Healthy pregnancy women
  • Pregnancy women with hypertension

    1. Despite the pregnant gestational age , systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured three times more than 24 hours apart
    2. Pregnant gestational age > 20 weeks, systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured twice more than 4 hours apart

Exclusion Criteria:

  • Lack of blood sample at the specified enrollment period
  • Women who refuse the study
  • Other illness which needs medications interfering with blood pressure (eg: Asthma requiring systemic steroids)
  • Known coronary artery disease or heart failure
  • Serious medical illness (eg: renal insufficiency, congestive heart disease, chronic respiratory insufficiency, uncontrolled infection).
  • multiple endocrine neoplasia or Cushing's syndrome or mixed tumours or pheochromocytoma or medullary thyroid carcinoma.
  • previous history of malignant tumour, with the exception of carcinoma in situ of the uterine cervix or non-melanoma skin cancer
  • renal insufficiency

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03200743

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Contact: Yuchen Pan, MD +8618810533382
Contact: Dan Zhu, MD

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China, Beijing
Peking University Third Hospital Recruiting
Beijin, Beijing, China, 100191
Contact: Yuchen Pan, MD    +8618810533382   
Contact: Dan Zhu, MD   
Sponsors and Collaborators
Yuchen Pan
Additional Information:

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Responsible Party: Yuchen Pan, Peking University Third Hospital Identifier: NCT03200743    
Other Study ID Numbers: 20170513
First Posted: June 27, 2017    Key Record Dates
Last Update Posted: June 27, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Yuchen Pan, Peking University Third Hospital:
Additional relevant MeSH terms:
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Hypertension, Pregnancy-Induced
Vascular Diseases
Cardiovascular Diseases
Pregnancy Complications