Bispectral Index (BIS) Values Required for an Adequate Depth of Anesthesia in Elderly Patients Using Propofol
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|ClinicalTrials.gov Identifier: NCT03195530|
Recruitment Status : Terminated (Out of funding, no differences between groups)
First Posted : June 22, 2017
Last Update Posted : April 11, 2018
A correlation between the bispectral index values and electroencephalographic patterns at the loss of consciousness (LOC) when using propofol in elderly patients, has not been determined.
Our aim is to describe the BIS values and the power of the alpha band in the electroencephalography in elderly patients, at the LOC moment.
|Condition or disease||Intervention/treatment|
Propofol is an anesthetic drug regularly used in elderly patients requiring anesthesia. The electroencephalographic pattern recognized when propofol is administered, is different to the pattern obtained in younger patients. Both groups presents an alpha and slow bands, but they differ in the intensity of the signal. Younger patients presents more intense electroencephalographic bands than older patients.
Bispectral index (BIS) is a clinical indicator used to evaluate the depth of anesthesia. A correlation between this indicator and the power of electroencephalographic bands has not been determined.
We will describe the LOC moment of elderly patients receiving propofol as anesthetic for general surgery, with the EEG characteristic bands and the BIS value obtained at that moment. The BIS values related to the EEG characteristic bands can be described, to correlate the actual indicators of depth of anesthesia with new parameters.
|Study Type :||Observational|
|Actual Enrollment :||12 participants|
|Official Title:||Bispectral Index (BIS) Values Required for an Adequate Depth of Anesthesia in Elderly Patients Using Propofol, According to the Characteristic Electroencephalographic Pattern|
|Actual Study Start Date :||May 1, 2017|
|Actual Primary Completion Date :||January 31, 2018|
|Actual Study Completion Date :||March 31, 2018|
Patients over 65 years, scheduled to general surgery, requiring general anesthesia
Induction of anesthesia using propofol, and recording the BIS values and EEG patterns during the induction
- BIS values at which EEG patterns (Slow and alpha bands) appears in elderly population using propofol [ Time Frame: Induction of anesthesia ]To describe the BIS values correlated to specific EEG patterns
- Propofol concentration required to observe specific EEG patterns [ Time Frame: Induction of anesthesia ]To describe the serum propofol concentrations required for induction of anesthesia, to observe alpha and slow bands at the EEG.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03195530
|Division de Anestesia - Pontificia Universidad Catolica de Chile|
|Santiago, Region Metropolitana, Chile, 8330024|