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Trial record 36 of 1007 for:    Area Under Curve AND insulin

Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance

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ClinicalTrials.gov Identifier: NCT03159065
Recruitment Status : Completed
First Posted : May 18, 2017
Last Update Posted : May 19, 2017
Sponsor:
Information provided by (Responsible Party):
Åsa Håkansson, Lund University

Brief Summary:
Consumption of polyphenol-rich fruits and vegetables may improve the postprandial glucose and insulin responses and hence promote well-being. It has previously been observed that consumption of a bilberry drink decreases the postprandial insulin demand. In the present study, the impact of probiotic fruit beverages with different polyphenol profiles on the postprandial levels of glucose and insulin, were investigated.

Condition or disease Intervention/treatment Phase
Postprandial Hyperglycemia Other: Bilberry Other: Blackcurrant Other: Mango Other: Beetroot Other: Rose hip Other: Glucose drink Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Screening
Official Title: Early Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance in Healthy Adults
Actual Study Start Date : September 2014
Actual Primary Completion Date : November 2014
Actual Study Completion Date : January 2015

Arm Intervention/treatment
Experimental: Bilberry
A bilberry-based beverage with fermented oatmeal
Other: Bilberry
Fruit beverage with bilberry and fermented oatmeal

Experimental: Blackcurrant
A blackcurrant-based beverage with fermented oatmeal
Other: Blackcurrant
Fruit beverage with blackcurrant and fermented oatmeal

Experimental: Mango
A mango-based based beverage with fermented oatmeal
Other: Mango
Fruit beverage with mango and fermented oatmeal

Experimental: Beetroot
A beetroot-based based beverage with fermented oatmeal
Other: Beetroot
Fruit beverage with beetroot and fermented oatmeal

Experimental: Rose hip
A rose hip-based based beverage with fermented oatmeal
Other: Rose hip
Fruit beverage with rose hip and fermented oatmeal

Active Comparator: Glucose drink
A reference glucose drink
Other: Glucose drink
A reference glucose drink




Primary Outcome Measures :
  1. Efficacy of the study products on the postprandial serum insulin [ Time Frame: Incremental area under the curve for serum insulin from 0 min up to 120 min following the ingestion of the study product ]
    The postprandial incremental area under the curve for serum insulin


Secondary Outcome Measures :
  1. Efficacy of the study products on the postprandial serum glucose [ Time Frame: Incremental area under the curve for serum glucose from 0 min up to 120 min following the ingestion of the study product ]
    The postprandial incremental area under the curve for serum glucose



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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy, not on medication, non-allergic, individuals aged 18-65 years old, having a BMI between 20-30 kg/m2 and also maintaining stable body weight, i.e. less than 5% weight change in the last three months before the study.

Exclusion Criteria:

-


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03159065


Sponsors and Collaborators
Lund University
Investigators
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Study Director: Yvonne Granfeldt, Prof Lund University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Åsa Håkansson, Associate Senior Lecturer, Lund University
ClinicalTrials.gov Identifier: NCT03159065     History of Changes
Other Study ID Numbers: InVeg (1)
First Posted: May 18, 2017    Key Record Dates
Last Update Posted: May 19, 2017
Last Verified: May 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Insulin Resistance
Hyperglycemia
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases