Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or Colon Cancer
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|ClinicalTrials.gov Identifier: NCT03137706|
Recruitment Status : Recruiting
First Posted : May 3, 2017
Last Update Posted : May 16, 2019
|Condition or disease||Intervention/treatment|
|Colon Carcinoma Liver and Intrahepatic Bile Duct Carcinoma Pancreatic Carcinoma||Procedure: Biospecimen Collection Other: Laboratory Biomarker Analysis Other: Laboratory Procedure|
I. To determine if our optical polarimeter device is able to measure tissue stiffness across several human cancer types ex vivo.
I. To describe the inter- and intra-tumor heterogeneity of tissue stiffness. II. To determine if the measurements made by the optical polarimeter device are non-destructive.
I. Perform multi-variable cross-correlation statistical analysis to determine relationships between: tissue stiffness characteristics, molecular level signatures, and cellular level properties, and if numbers permit, response to treatment.
Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue samples are analyzed for tissue stiffness measurements using an optical polarimeter device and cell viability using an automated cell counter.
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Official Title:||Characterization of Mechanical Tissue Properties in Pancreas, Liver and Colon|
|Actual Study Start Date :||November 14, 2016|
|Estimated Primary Completion Date :||February 14, 2020|
|Estimated Study Completion Date :||February 14, 2021|
Ancillary-correlative (tissue stiffness analysis)
Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue samples are analyzed for tissue stiffness measurements using optical polarimeter device and cell viability using automated cell counter.
Procedure: Biospecimen Collection
Undergo fresh tumor tissue collection
Other: Laboratory Biomarker Analysis
Other: Laboratory Procedure
Tissue stiffness and cell viability analysis
- Young's modulus (stiffness) on fresh tissue [ Time Frame: Up to 15 months ]A portable optical fiber polarimetric sensor device to measure the Young's modulus in tissue samples will be used.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03137706
|Contact: Olga Castellanosfirstname.lastname@example.org|
|United States, California|
|USC / Norris Comprehensive Cancer Center||Recruiting|
|Los Angeles, California, United States, 90033|
|Contact: Shannon Mumenthaler 323-442-2529 email@example.com|
|Principal Investigator: Shannon Mumenthaler|
|Principal Investigator:||Shannon Mumenthaler, Ph.D.||University of Southern California|