Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke (CUSCAS)
|ClinicalTrials.gov Identifier: NCT03115242|
Recruitment Status : Completed
First Posted : April 14, 2017
Last Update Posted : March 15, 2018
|Condition or disease||Intervention/treatment||Phase|
|Cerebral Infarction||Other: Contrast injection Sonovue®||Not Applicable|
The main objective of this study is to evaluate the prevalence of the contrast taking carotid plaques in these acute ischemic strokes.
The secondary objectives are:
- to determine the clinical, sonographic, CT scanner and MRI characteristics of patients in constituted acute cerebral ischemia with carotid atherosclerotic plaque taking contrast to the doppler ultrasound.
- to explore of the plaque contrast enhancement at 6 months (new injection).
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||35 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke|
|Actual Study Start Date :||August 2015|
|Actual Primary Completion Date :||August 2017|
|Actual Study Completion Date :||August 2017|
Experimental: Acute ischemic carotid stroke
Patients hospitalized in the neurovascular intensive care unit for an acute ischemic stroke with a carotid plaque responding to inclusion criteria.
These patients receive a contrast injection Sonovue® will be performed during the neck vessels doppler ultrasound.
Other: Contrast injection Sonovue®
In addition to standardized assessment routine care, a contrast injection will be performed during the neck vessels doppler ultrasound.
- Contrast enhancement of carotid plaque prevalence in ultrasound doppler [ Time Frame: Day 1 ]
- Patient's demographics data [ Time Frame: Day 1 ]
- Patient's sonographic and MRI characteristics. [ Time Frame: Day1 ]confirmation of the recent character of stroke on the DWI, search for stroke sequelae and white matter disease on the FLAIR, search of the thrombus on the T2*, search occluded artery on the 3DTOF
- describe the aspect of the carotid plaque on CT angiography. [ Time Frame: between 1 to 5 days ]NASCET stenosis and the aspect (smooth, irregular, ulcerated)
- Persistence , decrease or loss of contrast enhancement in ultrasound doppler. [ Time Frame: Month 6 ]
- Cerebral infarction recurrence [ Time Frame: Month 6 ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03115242
|Centre Hospitalier de Versailles|
|Le Chesnay, France, 78150|
|Principal Investigator:||Jennifer YEUNG, Neurologist||Versailles Hospital|
|Principal Investigator:||Jean-Michel BAUD, Angiologist||Versailles Hospital|
|OverallOfficial:||Aurélien MAURIZOT, Angiologist||Versailles Hospital|
|OverallOfficial:||Simon CHABAY, Angiologist||Versailles Hospital|
|OverallOfficial:||Daniela STANCIU, Neurologist||Versailles Hospital|