Efficacy of Platelet-rich Plasma (PRP) in the Treatment of Dark Circles Under the Eyes
|ClinicalTrials.gov Identifier: NCT03114514|
Recruitment Status : Completed
First Posted : April 14, 2017
Last Update Posted : May 16, 2017
|Condition or disease||Intervention/treatment||Phase|
|Periorbital Hyperpigmentation||Biological: PRP||Not Applicable|
Dark circles around the eyes is a common problem pretending with relatively dark eyelids concerns many patients, especially women, because of the inconvenience caused by esthetic and negative impact on the psyche and the patient's quality of life. There are several causing factors (such as sun exposure, smoking, alcohol, sleep deprivation, genetic and structural factors). variety of treatments have been used for this situation , but without clear results.
The term 'Platelet-Rich Plasma (PRP)' is a general term used to describe hanging plasma that has been obtained from whole blood with concentration of platelets higher than normal concentration found in the circulating blood. PRP's work mechanism depends on the fact that platelets contain important substances called (growth factors), which have a known role in the process of reform and renewal of tissues.
Aim of the research:
This study was designed to evaluate the effectiveness of (PRP) injection in the treatment of dark circles under the eyes. This is an uncontrolled open therapeutic trial study which will be performed at the Hospital of Dermatology and Venereology of Damascus University in Damascus, Syria during the period from June 2016 to June 2017.
The results will be assessed by standardized digital photography month after each injection and three months after the latest assessment with the assistant of skin colors scale. In addition, the patient's satisfaction with the results and any treatment-related side effects will be recorded.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Efficacy of Platelet-Rich Plasma (PRP) in the Treatment of Periorbital Hyperpigmentation|
|Actual Study Start Date :||June 17, 2016|
|Actual Primary Completion Date :||April 20, 2017|
|Actual Study Completion Date :||May 10, 2017|
Experimental: PRP injection
A PRP-injection will be performed three times during the course of treatment
PRP will be injected subcutaneously around the eyes at three different time points with one-month interval
Other Name: platelet-rich plasma
- Change in Skin Color [ Time Frame: Color shade will be measured at one month following the first injection (T1) and at three months following the third injection (T2) ]Standardized digital photographs will be taken and a color scale will be used
- Satisfaction [ Time Frame: Satisfaction will be measured at three months following the last injection. ]Patients' satisfaction will be measured on a visual analog scale (VAS)
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03114514
|Syrian Arab Republic|
|Department of Dermatology and Venereology at Damascus University|
|Damascus, Syrian Arab Republic, DM20AM18|
|Principal Investigator:||Raed Sameer Noueihed, M.D.||Resident at the Dermatology and venereology Hospital of Damascus university.|