SEEG Investigation of Mood Dysregulation in Epilepsy
|ClinicalTrials.gov Identifier: NCT03097809|
Recruitment Status : Enrolling by invitation
First Posted : March 31, 2017
Last Update Posted : June 26, 2019
|Condition or disease||Intervention/treatment|
|Epilepsy||Other: SEEG Recordings|
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Official Title:||SEEG Investigation of Mood Dysregulation in People With Epilepsy|
|Actual Study Start Date :||February 27, 2017|
|Estimated Primary Completion Date :||December 2020|
|Estimated Study Completion Date :||July 2021|
Subjects will be recruited from the epilepsy-monitoring unit. These subjects would have been already assessed by the Epilepsy Center at the Cleveland Clinic for surgical treatment of medically refractory epilepsy and would have already had SEEG electrodes placed in cortical and limbic areas for clinical diagnostic purposes.
Other: SEEG Recordings
To directly record brain activity from the frontal-limbic circuitry of subjects in the resting state and while they engage in behavioral tasks designed to assess emotional response to negative stimuli and different aspects of impulse control and emotional processing
- Emotional Face Task and Emotional Go-No Go Task [ Time Frame: 2 years ]To use face pictures depicting negative, positive and neutral emotions this task measures brain area activation abnormalities while responding and inhibiting responses to positive and negative emotions.
- Maintaining and suppressing emotions [ Time Frame: 2 years ]To use the International Affective Picture System, subjects will be asked to either maintain or suppress their emotions.
- Resting state cortico-limbic brain connectivity [ Time Frame: 2 years ]Resting state recordings will be collected from the cortical areas - prefrontal cortex, orbitofrontal cortex and anterior and posterior cingulate cortex as well as limbic areas - amygdala and hippocampus
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03097809
|United States, Ohio|
|Cleveland Clinic Foundation Center for Behavioral Health|
|Cleveland, Ohio, United States, 44195|
|Principal Investigator:||Amit Anand, MD||The Cleveland Clinic|