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Trial record 18 of 215 for:    TETRACYCLINE

Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Methods

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ClinicalTrials.gov Identifier: NCT03095378
Recruitment Status : Completed
First Posted : March 29, 2017
Last Update Posted : March 29, 2017
Sponsor:
Information provided by (Responsible Party):
Carla Andreotti Damante, University of Sao Paulo

Brief Summary:
The aim of this study was to evaluate the effect of two root-conditioning agents used in conjunction with subepithelial connective graft technique on root coverage outcomes. One is citric acid plus tetracycline and the other is antimicrobial photodynamic therapy.

Condition or disease Intervention/treatment Phase
Gingival Recession Procedure: Control Procedure: citric acid plus tetracycline Procedure: antimicrobial photodynamic therapy Not Applicable

Detailed Description:

Citric acid plus tetracycline has properties of root surface decontamination, surface demineralization and exposure of collagen fibers.

Antimicrobial photodynamic therapy has been widely used in Periodontics to obtain reduction of periodontopathogenic bacteria with absence of systemic side effects and minimal bacterial resistance. Also, it has properties of root demineralization and exposure of collagen fibers. These properties may enhance root coverage in procedures of subepithelial connective graft.


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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Interventions in different patients
Masking: Single (Outcomes Assessor)
Masking Description: The outcome assessor did not have access to patient's records
Primary Purpose: Treatment
Official Title: Evaluation of Root Coverage by Subepithelial Connective Graft Associated to Root Conditioning by Citric Acid Plus Tetracycline and Antimicrobial Photodynamic Therapy: A Randomized Clinical Trial
Actual Study Start Date : March 10, 2014
Actual Primary Completion Date : February 10, 2017
Actual Study Completion Date : March 10, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antibiotics

Arm Intervention/treatment
Active Comparator: Control
Root treatment with scaling and root planing.
Procedure: Control
Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with scaling and root planing

Experimental: Citric acid plus tetracycline
Root treatment with 50% citric acid plus 10% tetracycline, pH1, passive application for 90s.
Procedure: citric acid plus tetracycline
Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with citric acid plus tetracycline

Experimental: Antimicrobial photodynamic therapy
Antimicrobial photodynamic therapy with toluidine blue O (100ug/ml - 60s pre-irradiation - pH4) and red laser (660nm, 30 milliwatts, 45 joules per square centimeter, sweeping mode, 90s)
Procedure: antimicrobial photodynamic therapy
Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with antimicrobial photodynamic therapy




Primary Outcome Measures :
  1. Total root coverage measured with a periodontal probe in mm [ Time Frame: one year ]
    Distance from cemento-enamel junction to gingival margin = 0 mm


Secondary Outcome Measures :
  1. Keratinized mucosa width measured with a periodontal probe in mm [ Time Frame: one year ]
    Ideal if keratinized mucosa width > 5mm

  2. Dentin hypersensitivity measured by applying an air jet on teeth and patient fills up a visual analogue scale [ Time Frame: one year ]
    Ideal if scale = 0



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Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Gingival recession - Miller's class I or II (2 to 5 mm of height) at least in one tooth
  • Indication of root coverage by dentin hypersensitivity or esthetic

Exclusion Criteria:

  • Smokers
  • Pregnancy
  • Systemic medication use that could impair wound healing or surgery procedure
  • Systemic diseases as diabetes, uncontrolled hypertension, coagulation diseases, kidney diseases.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03095378


Locations
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Brazil
Bauru School of Dentistry
Bauru, Sao Paulo, Brazil, 17012-901
Sponsors and Collaborators
University of Sao Paulo

Publications:
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Responsible Party: Carla Andreotti Damante, Associate professor, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT03095378     History of Changes
Other Study ID Numbers: BauruSchoolDentistryPDT
First Posted: March 29, 2017    Key Record Dates
Last Update Posted: March 29, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Carla Andreotti Damante, University of Sao Paulo:
gingival recession
Additional relevant MeSH terms:
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Tetracycline
Gingival Recession
Gingival Diseases
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases
Periodontal Atrophy
Anti-Bacterial Agents
Sodium Citrate
Citric Acid
Anti-Infective Agents
Protein Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anticoagulants
Calcium Chelating Agents
Chelating Agents
Sequestering Agents