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A Comparison of High-intensity Interval Training Protocols on Health and Fitness

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ClinicalTrials.gov Identifier: NCT03093441
Recruitment Status : Active, not recruiting
First Posted : March 28, 2017
Last Update Posted : August 22, 2018
Sponsor:
Information provided by (Responsible Party):
Elise Brown, Oakland University

Brief Summary:
Recently, it has been demonstrated that multimodal high-intensity interval training (MM-HIIT) (utilizing resistance-based and functional movements) can produce similar aerobic adaptations compared to high-intensity interval training (HIIT) using rowing but with greater muscle performance in females. In addition, HIIT has been shown to be more enjoyable than continuous training, and this may lead to enhanced self-efficacy and increased physical activity. To the investigators' knowledge, however, the cardiometabolic effects (blood pressure, abdominal/visceral fat, blood sugar, blood lipids/fats) of MM-HIIT have not been reported. The investigators aim to compare MM-HIIT with HIIT using a traditional aerobic fitness exercise (rowing) for the degree of cardiometabolic, physical performance (strength, endurance, power), and psychosocial (self-efficacy and enjoyment) adaptations.

Condition or disease Intervention/treatment Phase
Healthy Other: Multimodal High-Intensity Interval Training Intervention Not Applicable

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 72 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: A parallel-group randomized controlled trial will be conducted. Once initial screening is completed, participants will be randomized into one of three arms: 1) MM-HIIT, 2) R-HIIT, and 3) control.
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: A Comparison of High-intensity Interval Training Protocols on Cardiometabolic Markers, Physical Performance, and Psychosocial Markers in College Females
Actual Study Start Date : July 17, 2017
Estimated Primary Completion Date : October 8, 2018
Estimated Study Completion Date : December 8, 2018

Arm Intervention/treatment
Experimental: Multimodal
Multimodal High-Intensity Interval Training Intervention. This group will train using multimodal exercises for 5 sets of 60 seconds of all out work, followed by 3 minutes of rest. Each session will have the same exercises within each set, but every session will be different than the others for movements utilized. There will be three movements used in each set. The first movement will be a strength movement for 4-6 repetitions. The second movement follows the first immediately and is a faster body weight or light implement power movement for 6-8 repetitions. The third movement follows the second immediately and is a very fast, sprint-like movement for the remainder of the 60 seconds. The intent of each set is to be completed with as much effort as possible across the full 60 seconds.
Other: Multimodal High-Intensity Interval Training Intervention
The intervention will occur 3 times per week for 12 weeks and include a warm-up, MM-HIIT or R-HIIT training protocol, and a cool down.

Active Comparator: Rowing
Multimodal High-Intensity Interval Training Intervention. This group will train using a rowing ergometer for 5 sets of 60 seconds of all out work, followed by 3 minutes of rest (a total of 20 minutes each session). Each training session will be the same across the 12 weeks. The intent of each set is to be completed with as much effort as possible across the full 60 seconds.
Other: Multimodal High-Intensity Interval Training Intervention
The intervention will occur 3 times per week for 12 weeks and include a warm-up, MM-HIIT or R-HIIT training protocol, and a cool down.

No Intervention: Control
Multimodal High-Intensity Interval Training Intervention. This group will be instructed to continue with any activity they were involved in prior to the study and to not begin any new exercise programs during the course of the study. To incentive participation in this group, the control group will be offered the MM-HIIT intervention the following semester at no cost.



Primary Outcome Measures :
  1. Aerobic fitness [ Time Frame: 15 minutes ]
    Aerobic fitness will be directly assessed by a VO2max bicycle test. Each participant will be allowed to warm-up on the bicycle for 5 minutes at a low intensity. The VO2max bicycle test will include 3 minute stages with increasing intensity each stage of 30 - 60 watts. The required cadence will be maintained at 60 RPMs (revolutions per minute) for each stage. The test will be terminated at volitional fatigue defined as the participant no longer able to maintain 60 RPMs for 20 seconds after encouragement from the testers. For most people, the test will take approximately 10 minutes.


Secondary Outcome Measures :
  1. Triglycerides [ Time Frame: 10 minutes ]
    Following a 12-hour fast, participants will complete venipuncture collection procedures. Two invasive needle sticks will be performed during this investigation (one needle stick pre-intervention and another needle stick post-intervention). Four milliliters (mL) of blood will be collected both pre- and post-intervention for measurement of triglycerides (mmol/L). This total amount of blood (8mL) collected during this trial will equate to 1.6 teaspoons of blood (5mL = 1 teaspoon).

  2. Physical Activity Enjoyment scale [ Time Frame: 5 minutes ]
    The purpose of including this psychosocial assessment in the proposed study is to assess changes in physical activity enjoyment. Physical Activity Enjoyment Scale


Other Outcome Measures:
  1. Muscular Endurance [ Time Frame: 5 minutes ]
    Muscle endurance will be assessed by repetitive back squats to voluntary exhaustion. The load will be set at 70% of the pre-training 1RM back squat for both pre- and post-training tests. The total number of repetitions will be recorded.

  2. Total Cholesterol [ Time Frame: 5 minutes ]
    Following a 12-hour fast, participants will complete venipuncture collection procedures. Two invasive needle sticks will be performed during this investigation (one needle stick pre-intervention and another needle stick post-intervention). Four milliliters (mL) of blood will be collected both pre- and post-intervention for measurement of: total cholesterol (mmol/L), alanine aminotransferase, aspartate aminotransferase, glucose, and low-density lipoprotein cholesterol. This total amount of blood (8mL) collected during this trial will equate to 1.6 teaspoons of blood (5mL = 1 teaspoon).

  3. Visceral Fat [ Time Frame: 5 minutes ]
    For this measurement of visceral fat, each participant will be asked to lie flat on a special table below the DXA scan. A trained technician will position each participant's body under the scan and then perform the scan.

  4. Muscular Strength [ Time Frame: 90 minutes ]
    Each participant will complete three days of testing, with at least 48 hours between testing days. These testing sessions will occur at OU Recreation Center. Each of these test sessions will be preceded by a standardized warmup and instruction regarding the upcoming session. On separate days, muscle strength will be assessed using 1-repetition maximum (1RM) testing for back squat, press, and deadlift using standardized protocols. The back squat will be performed to below parallel (hip crease below the apex of the patella), the press will be initiated with the bar on the clavicles, and the deadlift will performed in the conventional stance. All testing days will be repeated following training.

  5. Muscular Power [ Time Frame: 10 minutes ]
    Muscle power will be assessed using a static broad jump. The best horizontal distance achieved out of 3 trials will be recorded. This test will be conducted immediately after the 1 RM testing for the deadlift.

  6. High-density lipoprotein cholesterol [ Time Frame: 10 minutes ]
    Following a 12-hour fast, participants will complete venipuncture collection procedures. Two invasive needle sticks will be performed during this investigation (one needle stick pre-intervention and another needle stick post-intervention). Four milliliters (mL) of blood will be collected both pre- and post-intervention for measurement of high-density lipoprotein cholesterol (mmol/L). This total amount of blood (8mL) collected during this trial will equate to 1.6 teaspoons of blood (5mL = 1 teaspoon).

  7. Alanine Aminotransferase [ Time Frame: 10 minutes ]
    Following a 12-hour fast, participants will complete venipuncture collection procedures. Two invasive needle sticks will be performed during this investigation (one needle stick pre-intervention and another needle stick post-intervention). Four milliliters (mL) of blood will be collected both pre- and post-intervention for measurement of alanine aminotransferase (U/L). This total amount of blood (8mL) collected during this trial will equate to 1.6 teaspoons of blood (5mL = 1 teaspoon).

  8. Asparate Aminotransferase [ Time Frame: 10 minutes ]
    Following a 12-hour fast, participants will complete venipuncture collection procedures. Two invasive needle sticks will be performed during this investigation (one needle stick pre-intervention and another needle stick post-intervention). Four milliliters (mL) of blood will be collected both pre- and post-intervention for measurement of asparate aminotransferase (U/L). This total amount of blood (8mL) collected during this trial will equate to 1.6 teaspoons of blood (5mL = 1 teaspoon).

  9. Glucose [ Time Frame: 10 minutes ]
    Following a 12-hour fast, participants will complete venipuncture collection procedures. Two invasive needle sticks will be performed during this investigation (one needle stick pre-intervention and another needle stick post-intervention). Four milliliters (mL) of blood will be collected both pre- and post-intervention for measurement of glucose (mmol/L). This total amount of blood (8mL) collected during this trial will equate to 1.6 teaspoons of blood (5mL = 1 teaspoon).

  10. Low-density lipoprotein cholesterol [ Time Frame: 10 minutes ]
    Following a 12-hour fast, participants will complete venipuncture collection procedures. Two invasive needle sticks will be performed during this investigation (one needle stick pre-intervention and another needle stick post-intervention). Four milliliters (mL) of blood will be collected both pre- and post-intervention for measurement of low-density lipoprotein cholesterol (mmol/L). This total amount of blood (8mL) collected during this trial will equate to 1.6 teaspoons of blood (5mL = 1 teaspoon).

  11. Exercise Self-Efficacy Scale [ Time Frame: 5 minutes ]
    The purpose of including this psychosocial assessments in the proposed study is to assess changes in exercise self-efficacy. Exercise Self-efficacy Scale.

  12. Body Mass Index [ Time Frame: 1 minutes ]
    Anthropometrics such as height (cm) using a stadiometer and weight (kg) using an eye-level beam scale will be obtained. Height and weight will then be converted to body mass index (kg/m2)

  13. Weight [ Time Frame: 1 minutes ]
    Anthropometrics such as weight (kg) using an eye-level beam scale will be obtained. Height and weight will then be converted to body mass index (kg/m2)

  14. Height [ Time Frame: 1 minutes ]
    Anthropometrics such as height (cm) using a stadiometer will be obtained. Height and weight will then be converted to body mass index (kg/m2)

  15. Waist Circumference [ Time Frame: 5 minutes ]
    Anthropometrics such as waist circumference (cm) using a Gulick tape will be obtained.

  16. Blood Pressure [ Time Frame: 10 minutes ]
    Vital sign measures such as and blood pressure (mmHg) sitting using a sphygmomanometer will be obtained.

  17. Heart Rate [ Time Frame: 2 minutes ]
    Vital sign measures such as heart rate (bpm) will be obtained.



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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Potential participants will be non-obese (waist circumference ≤ 88 cm) recreationally active females aged 18 - 40 years who do not engage in a regular training program. Recreationally active is defined as periodically participating in physical activity or exercise between 1 - 3 hours a week for at least a month, but not involved in a systematic endurance or weight training activity.

Exclusion Criteria:

  • Potential participants will be excluded if they have a history of exercise-limiting cardiovascular, respiratory, metabolic, or musculoskeletal illness/injury or if they are currently taking medication that would alter the physiological responses to exercise. They will also be excluded if they are pregnant or have a history of fainting while giving blood.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03093441


Locations
United States, Michigan
Oakland University
Rochester, Michigan, United States, 48309
Sponsors and Collaborators
Oakland University
Investigators
Principal Investigator: Elise Brown, PhD Oakland University

Responsible Party: Elise Brown, Assistant Professor, Oakland University
ClinicalTrials.gov Identifier: NCT03093441     History of Changes
Other Study ID Numbers: OU1002886
First Posted: March 28, 2017    Key Record Dates
Last Update Posted: August 22, 2018
Last Verified: August 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Elise Brown, Oakland University:
High-intensity interval training
cardiometabolic
physical performance
psychosocial adaptation