Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome
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|ClinicalTrials.gov Identifier: NCT03092609|
Recruitment Status : Recruiting
First Posted : March 28, 2017
Last Update Posted : March 29, 2018
|Condition or disease||Intervention/treatment||Phase|
|Anxiety||Behavioral: Attention Bias Modification Behavioral: Attention Control||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome|
|Actual Study Start Date :||December 15, 2017|
|Estimated Primary Completion Date :||September 14, 2020|
|Estimated Study Completion Date :||September 14, 2020|
|Experimental: Attention Bias Modification||
Behavioral: Attention Bias Modification
Attention bias modification (ABM) sessions will consist of a modified dot-probe task that only contains incongruent trials (i.e., target-dot - neutral stimulus 100% pairing).
|Active Comparator: Attention Control||
Behavioral: Attention Control
Attention control (AC) sessions, will consist of a standard dot-probe task (i.e., target-dot - neutral/threat stimulus 50% pairing). Thus, for AC participants, bias should remain the same, while ABM participants should show a reduced bias to threat.
- Attentional Bias [ Time Frame: Baseline and after 6 weeks of the intervention ]Reaction time difference to congruent and incongruent trials in the dot-probe task, which measure heightened attentional bias to threat.
- State and Trait Anxiety [ Time Frame: Baseline and after 6 weeks of the intervention ]Anxiety as measured by the Speilberger State-Trait Anxiety Inventory
- MRI measures of gray matter volume [ Time Frame: Baseline and after 6 weeks of the intervention ]T1-weighted MRI measures of gray matter volume
- MRI measures of structural and functional connectivity [ Time Frame: Baseline and after 6 weeks of the intervention ]Diffusion-tensor weighted MRI based measures of structural connectivity and functional MRI based measures of functional connectivity.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03092609
|Contact: Lin Fang, PhDemail@example.com|
|United States, Michigan|
|Northern Michigan University||Recruiting|
|Marquette, Michigan, United States, 49855|
|Contact: Lin Fang, PhD 906-227-2954 firstname.lastname@example.org|
|Principal Investigator:||Joshua M Carlson, PhD||Northern Michigan University|