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Brain Imaging, Attention, and Auditory Processing in Schizophrenia

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ClinicalTrials.gov Identifier: NCT03068806
Recruitment Status : Completed
First Posted : March 3, 2017
Last Update Posted : November 30, 2018
Sponsor:
Information provided by (Responsible Party):
Judith Ford, San Francisco Veterans Affairs Medical Center

Brief Summary:
This is a research study designed to examine how the psychiatric illness called schizophrenia affects brain function and thinking abilities such as attention and memory during simple computer-based tasks, and how measures of brain function are related to performance. The investigators do this by looking at brain activity using electroencephalography (EEG) and magnetic resonance imaging (MRI). The investigators compare participants' results to the activity in their brain as well as clinical measures and questionnaires also completed during this study.

Condition or disease Intervention/treatment
Schizophrenia Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)

  Show Detailed Description

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Study Type : Observational
Actual Enrollment : 202 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Predictive Coding Abnormalities in Psychosis: EEG and fMRI
Actual Study Start Date : December 1, 2014
Actual Primary Completion Date : May 11, 2018
Actual Study Completion Date : May 11, 2018

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Patients with Schizophrenia
Individuals who have been previously diagnosed with schizophrenia and meet our research criteria for symptoms indicative of schizophrenia within their lifetime.
Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)
The investigators will use these techniques combined with attention tests, memory tests, and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia and healthy controls.

Healthy Controls
Individuals who have not met criteria for a psychiatric disorder within their lifetime according to our research criteria for symptoms indicative of a psychiatric disorder.
Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)
The investigators will use these techniques combined with attention tests, memory tests, and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia and healthy controls.




Primary Outcome Measures :
  1. EEG [ Time Frame: Day 1 ]
    Electroencephalography, measures signals from the brain while participants conduct specific tasks that measure memory and attention.

  2. MRI [ Time Frame: Day 1 ]
    Magnetic Resonance Imaging, measures activity in, and takes detailed pictures of the brain while participants conduct specific tasks that measure memory and attention.

  3. Memory and Attention tasks [ Time Frame: Day 1 ]
    Tasks involve saying words, pressing buttons at specific times, listening, and viewing pictures.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients who have been diagnosed with schizophrenia and meet our research criteria of symptoms indicative of a diagnosis of schizophrenia within their lifetime are eligible for this study.

Healthy controls who have never met criteria for a psychiatric disorder and meet our research criteria will also be included in this study.

Criteria

Inclusion Criteria:

  • The subject population will include 18 to 75 year old participants of any gender, race, and ethnicity. All subjects will be able to speak and understand English.

Schizophrenia subjects:

1. Patients must be diagnosed with DSM-IV schizophrenia, schizophreniform, or schizoaffective disorder based on a SCID-P interview.

Comparison subjects:

1. Control participants must not have past or present Axis I diagnosis as determined by the SCID-NP.

Exclusion Criteria:

  • All subjects:

    1. A hearing deficit greater than 40dB in both ears detected during the hearing test
    2. Substance dependence, as per clinical judgment, in the past 1 year (except caffeine and nicotine)
    3. A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic or neurological
    4. History of head injury with loss of consciousness greater than 15 minutes
    5. Any other condition or medication, which in the opinion of the investigator would preclude participation in the study.
    6. Non-English speaking.

Comparison subjects:

1. Any first-degree relative with schizophrenia or bipolar disorder.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03068806


Locations
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United States, California
San Francisco VA Medical Center
San Francisco, California, United States, 94121
Sponsors and Collaborators
San Francisco Veterans Affairs Medical Center
Investigators
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Principal Investigator: Judith Ford, PhD San Francisco VA Medical Center

Additional Information:
Publications of Results:

Other Publications:

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Responsible Party: Judith Ford, Research Scientist and Professor of Psychiatry, San Francisco Veterans Affairs Medical Center
ClinicalTrials.gov Identifier: NCT03068806     History of Changes
Other Study ID Numbers: MH058262
First Posted: March 3, 2017    Key Record Dates
Last Update Posted: November 30, 2018
Last Verified: November 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders