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Trial record 92 of 10364 for:    strength

The Effect of a Protein Hydrolysate on Muscle Strength Recovery

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03063346
Recruitment Status : Completed
First Posted : February 24, 2017
Last Update Posted : March 3, 2017
Information provided by (Responsible Party):

Brief Summary:

Overtraining is a real problem for (semi-)professional athletes. Overtraining is often caused by the bodies' lack of ability to recover between training. In addition, during high intensity training reactive oxygen species are formed up to 20 fold compared to resting values. This causes increased muscle tissue damage after intense exercise, which slows down recovery. Improving recovery may increase an athlete's ability to reach higher training volumes resulting in establishing a higher performance plateau.

It is known that hydrolyzed proteins have a positive effect on muscle protein synthesis due to its faster absorption rate. Therefore, it is hypothesized that a known protein hydrolysate may have positive effects on strength recovery.

Condition or disease Intervention/treatment Phase
Muscle Strength Recovery Dietary Supplement: Protein hydrolysate high dose Dietary Supplement: Protein hydrolysate low dose Dietary Supplement: Placebo Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 48 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Effect of a Protein Hydrolysate on Muscle Strength Recovery in Athletes
Actual Study Start Date : June 6, 2016
Actual Primary Completion Date : February 9, 2017
Actual Study Completion Date : February 20, 2017

Arm Intervention/treatment
Experimental: Protein hydrolysate high dose Dietary Supplement: Protein hydrolysate high dose
Experimental: Protein hydrolysate low dose Dietary Supplement: Protein hydrolysate low dose
Placebo Comparator: Placebo Dietary Supplement: Placebo

Primary Outcome Measures :
  1. Muscle strength recovery [ Time Frame: 4 weeks ]
    difference in peak force between the exhaustion challenge and the recovery challenge, measured with a linear encoder during a squat exercise

Secondary Outcome Measures :
  1. Blood lactate buildup [ Time Frame: 4 weeks ]
    in mmol/L, measured trough a finger prick after exhaustion and recovery challenge

  2. Body composition [ Time Frame: 4 weeks ]
    fat percentage, based on 4-point skin fold measurement

  3. Exercise volume [ Time Frame: 4 weeks ]
    amount of repetitions x time taken x power, measured with a linear encoder during squat exercise

  4. Peak force output [ Time Frame: 4 weeks ]
    measured with a linear encoder during the squat exercise

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy individuals (based on their medical history provided during a general health questionnaire)
  • Participants are amateur or (semi-) professional athletes in resistance or interval sports (engage in >6 hours of intense physical activity per week).
  • Age 18 - 35
  • Experience in resistance training

Exclusion Criteria:

  • Use of creatine supplements and/or anabolic steroids.
  • Allergy to test product/protein
  • Allergy to specific protein hydrolysate
  • BMI lower than 18 or higher than 30.
  • Lack of technique in correctly performing a barbell squat (judged by sports physiologist).
  • Recent muscle injury in legs or back less than one month before the start of the study.
  • Cardiovascular complications
  • Use of medication
  • Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator), in the 180 days prior to the study.
  • Abuse of products; alcohol (> 20 alcoholic units per week) and drugs

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Responsible Party: BioActor Identifier: NCT03063346     History of Changes
Other Study ID Numbers: MU-001
First Posted: February 24, 2017    Key Record Dates
Last Update Posted: March 3, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided