Genetic Basis of Melanocytic Nevi
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|ClinicalTrials.gov Identifier: NCT03054584|
Recruitment Status : Recruiting
First Posted : February 15, 2017
Last Update Posted : October 30, 2019
The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.
Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:
- From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.
- From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
|Condition or disease||Intervention/treatment|
|Melanocytic Nevi||Other: Collecting Nevi|
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||Genetic Basis of Melanocytic Nevi|
|Actual Study Start Date :||June 26, 2017|
|Estimated Primary Completion Date :||January 2025|
|Estimated Study Completion Date :||January 2025|
- Other: Collecting Nevi
Will be collecting Nevi and completing a DNA analysis, no intervention will be made.
- Genome Wide Mutation Analysis [ Time Frame: Feb 2017 - December 2018 ]Will be performing genome wide mutation analysis to quantify the number of mutations.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03054584
|Contact: Maija Kiuru, MDemail@example.com|
|Contact: Iryna Rybakfirstname.lastname@example.org|
|United States, California|
|University of California-Davis, Department of Dermatology||Recruiting|
|Sacramento, California, United States, 95816|
|Contact: Iryna Rybak 916-734-1509 email@example.com|