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The Effects of a Train High, Sleep Low Strategy

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ClinicalTrials.gov Identifier: NCT03045588
Recruitment Status : Completed
First Posted : February 7, 2017
Last Update Posted : October 24, 2018
Sponsor:
Collaborator:
Team Denmark
Information provided by (Responsible Party):
University of Aarhus

Brief Summary:
The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise. This is done with a 4 week intervention study with moderately trained cyclists. Performance is tested pre and post intervention and muscle biopsies are obtained.

Condition or disease Intervention/treatment Phase
Cycling Performance Muscular Adaptations Substrate Utilization Other: Combined exercise and diet intervention Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Other
Official Title: The Effects of a Train High, Sleep Low Strategy on Performance, Substrate Utilization and Muscular Adaptations in Moderately Trained Cyclists
Actual Study Start Date : October 1, 2016
Actual Primary Completion Date : December 20, 2016
Actual Study Completion Date : October 10, 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Low group
This subjects in this group conducts all their morning exercise sessions with high fat oxidation (in a fasted condition). Thus, the subjects in this group after high intensity exercise in the evening do not get any carbohydrates to eat after training until the exercise session the following morning has been conducted.
Other: Combined exercise and diet intervention
Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.

Active Comparator: High group
This subjects in this group conducts all their morning exercise sessions with low fat oxidation (in a fed condition). Thus, the subjects in this group after high intensity exercise in the evening do get carbohydrates to eat after training until the exercise session the following morning has been conducted.
Other: Combined exercise and diet intervention
Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.




Primary Outcome Measures :
  1. Time trial performance measured in Watts [ Time Frame: Change from Baseline and after 4 weeks of training ]
    30 min time trial after 90 minutes of intensive cycling. The average amount of Watts during the 30 minutes will be measured.


Secondary Outcome Measures :
  1. Protein expression in skeletal muscle tissue [ Time Frame: Baseline and after 4 weeks of training ]
    Amount of mitochondrial proteins and enzymes will be measured with a Western Blotting technique

  2. The absolute amount of carbohydrate and fat which is metabolised during morning exercise, measured in grams/minute [ Time Frame: Baseline and after 4 weeks of training ]
    Fat and carbohydrate oxidation during exercise measured and estimated with indirect calorimetry.



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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Gender Based Eligibility:   Yes
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18-45 years
  • VO2-max>55 ml/kg/min
  • No smokers
  • Training 6 hours per week (cycling)
  • Training experience for more than 3 years.

Exclusion Criteria:

  • Less than 2 g carbohydrate/kg/day

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Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT03045588    
Other Study ID Numbers: Sleep low
First Posted: February 7, 2017    Key Record Dates
Last Update Posted: October 24, 2018
Last Verified: October 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No