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Association of Long-term Conditions With Survival Following Heart Attack in England and Wales

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ClinicalTrials.gov Identifier: NCT03037255
Recruitment Status : Unknown
Verified January 2017 by Marlous Hall, University of Leeds.
Recruitment status was:  Active, not recruiting
First Posted : January 31, 2017
Last Update Posted : January 31, 2017
Sponsor:
Information provided by (Responsible Party):
Marlous Hall, University of Leeds

Brief Summary:
This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.

Condition or disease Intervention/treatment
Acute Myocardial Infarction Diabetes Mellitus Peripheral Vascular Disease Chronic Heart Failure Cerebrovascular Disease Chronic Renal Failure Chronic Obstructive Pulmonary Disease Other: long term conditions

Detailed Description:
Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.

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Study Type : Observational [Patient Registry]
Actual Enrollment : 693633 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 8 Years
Official Title: Association of Long-term Conditions With Survival Following Acute Myocardial Infarction in England and Wales
Study Start Date : January 2003
Actual Primary Completion Date : December 2013
Estimated Study Completion Date : January 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack


Intervention Details:
  • Other: long term conditions
    Long term conditions including diabetes mellitus, chronic obstructive pulmonary disease or asthma, chronic heart failure, chronic renal failure, cerebrovascular disease or peripheral vascular disease.


Primary Outcome Measures :
  1. Number of patients who died from any cause by the end of the study censoring period [ Time Frame: 8.4 years ]
    Death data was obtained from national death records from the Office for National Statistics


Secondary Outcome Measures :
  1. Number of patients who received guideline recommended therapy during the study period [ Time Frame: Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days ]
    All guideline recommended therapies for acute myocardial infarction relevant to the duration of the study period (2003 to 2013) will be assessed.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) admitted to one of 247 hospitals in England and Wales between 1st January 2003 and 30th June 2013
Criteria

Inclusion Criteria:

  • Patients must be 18 years or older

Exclusion Criteria:

  • Patients for which mortality data are missing

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03037255


Sponsors and Collaborators
Marlous Hall
Investigators
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Principal Investigator: Chris Gale, PhD, FRCP University of Leeds

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Marlous Hall, Co-Investigator, University of Leeds
ClinicalTrials.gov Identifier: NCT03037255     History of Changes
Other Study ID Numbers: UoL_LTC
First Posted: January 31, 2017    Key Record Dates
Last Update Posted: January 31, 2017
Last Verified: January 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Additional relevant MeSH terms:
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Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Cerebrovascular Disorders
Kidney Failure, Chronic
Heart Failure
Myocardial Infarction
Vascular Diseases
Peripheral Vascular Diseases
Peripheral Arterial Disease
Infarction
Heart Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Renal Insufficiency
Kidney Diseases
Urologic Diseases
Atherosclerosis
Arteriosclerosis
Arterial Occlusive Diseases
Renal Insufficiency, Chronic
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases