Association of Long-term Conditions With Survival Following Heart Attack in England and Wales
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This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.
Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.
Number of patients who died from any cause by the end of the study censoring period [ Time Frame: 8.4 years ]
Death data was obtained from national death records from the Office for National Statistics
Secondary Outcome Measures :
Number of patients who received guideline recommended therapy during the study period [ Time Frame: Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days ]
All guideline recommended therapies for acute myocardial infarction relevant to the duration of the study period (2003 to 2013) will be assessed.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) admitted to one of 247 hospitals in England and Wales between 1st January 2003 and 30th June 2013