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Gastric Emptying of Rice With Different Starch Properties

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ClinicalTrials.gov Identifier: NCT03035981
Recruitment Status : Completed
First Posted : January 30, 2017
Last Update Posted : January 30, 2017
Sponsor:
Information provided by (Responsible Party):
Bruce R. Hamaker, Purdue University

Brief Summary:
Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has been studied for the purpose of slowing their digestion rate and improving related physiological outcomes, such as gastric emptying rate. The current study investigated the relationship among starch digestion, gastric emptying rate and satiety in white and brown rice.

Condition or disease Intervention/treatment Phase
Appetitive Behavior Other: White rice, low amylose Other: White rice, high amylose Other: White rice, slow Other: White rice, resistant Other: Brown rice, low amylose Other: Brown rice, high amylose Other: Fructooligosaccharide (FOS) Not Applicable

Detailed Description:
Studies have indicated that starch-based foods with somewhat high amylose content have slower in vitro starch digestion rates, which relate to a low glycemic response. Low glycemic response is associated with delayed gastric emptying rate as well. Therefore, we hypothesized that rice with a slow starch digesting property would delay gastric emptying. White and brown rice with varying amylose contents were used in this study. A 13C-labeled octanoic acid breath test method was used to measure gastric emptying rate, and questionnaires were used to assess hunger and fullness during the testing sessions. Twelve healthy volunteers were recruited to participate in a crossover design study with six rice treatments and outcome measurements were gastric emptying and satiety assessments. One fermentable carbohydrate (fructooligosaccharide, FOS) solution was used to validate the production of breath hydrogen.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Other
Official Title: Assessment of Gastric Emptying and Fullness of Rice With Different Starch Properties
Study Start Date : August 2014
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

Drug Information available for: Starch

Arm Intervention/treatment
Experimental: White rice, low amylose
Cooked white rice with low amylose content
Other: White rice, low amylose
White and brown rice were tested for differences in gastric emptying rate and appetitive response

Experimental: White rice, high amylose
Cooked white rice with high amylose content
Other: White rice, high amylose
White and brown rice were tested for differences in gastric emptying rate and appetitive response

Experimental: White rice, slow
Cooked white rice with slow digesting starch
Other: White rice, slow
White and brown rice were tested for differences in gastric emptying rate and appetitive response

Experimental: White rice, resistant
Cooked white rice with resistant starch
Other: White rice, resistant
White and brown rice were tested for differences in gastric emptying rate and appetitive response

Experimental: Brown rice, low amylose
Cooked brown rice with low amylose content
Other: Brown rice, low amylose
White and brown rice were tested for differences in gastric emptying rate and appetitive response

Experimental: Brown rice, high amylose
Cooked brown rice with high amylose content
Other: Brown rice, high amylose
White and brown rice were tested for differences in gastric emptying rate and appetitive response

Experimental: Fructooligosaccharide (FOS)
Fermentable carbohydrate solution
Other: Fructooligosaccharide (FOS)
White and brown rice were tested for differences in gastric emptying rate and appetitive response




Primary Outcome Measures :
  1. Gastric emptying [ Time Frame: Acute study, 4 hours after consumption of test food ]
    Breath test was performed using 13C-octanoic acid mixed into test meals

  2. Appetitive response [ Time Frame: Acute study, 4 hours after consumption of test food ]
    Fullness and hunger questionnaire was given at various time points after consumption of test foods


Secondary Outcome Measures :
  1. Breath hydrogen [ Time Frame: Acute study, 4 hours after consumption of test food ]
    Hydrogen breath test was performed following ingestion of test meals



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

Exclusion Criteria:

  • Under any medication
  • History of any gastrointestinal disease or surgery
  • Diabetes
  • Smoker

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Responsible Party: Bruce R. Hamaker, Professor, Purdue University
ClinicalTrials.gov Identifier: NCT03035981     History of Changes
Other Study ID Numbers: 1405014904
First Posted: January 30, 2017    Key Record Dates
Last Update Posted: January 30, 2017
Last Verified: January 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No