Influence of Training Intensity in Coronary Artery Disease
|ClinicalTrials.gov Identifier: NCT03034980|
Recruitment Status : Completed
First Posted : January 27, 2017
Last Update Posted : February 27, 2018
Coronary artery disease (CAD) is associated with high mortality worldwide. Narrowing of the coronary arteries can cause an acute myocardial infarction. Patient with cardiac ischemia are often treated with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Following hospitalisation, the patients are offered to attend a classical rehabilitation program with moderate exercise intensity. Current exercise program for cardiac rehabilitation has proven to reduce cardiovascular risk factors 1. Is it possible to improve the exercise capacity and risk profile even more if the exercise program includes more vigorous training? The program starts one week after the cardiac incident (AMI, PCI or CABG) and takes 12 weeks to complete. Patients with heart failure and valvular disease are excluded. First ventilatory threshold (VT1) and second ventilatory threshold (VT2) are determined during cycloerometry. VT2 reflects aerobic-anaerobic transition and therefore the aerobic functional capacity2. Exercise load reached at VT2 is used to determine the training load during rehabilitation.
The research goal is to investigate the influence of training intensity on the exercise capacity and risk profile of CAD patients.
|Condition or disease||Intervention/treatment|
|Coronary Artery Disease||Other: Training intensity (workload) during ergospirometry|
|Study Type :||Observational|
|Estimated Enrollment :||343 participants|
|Official Title:||Influence of Training Intensity on Exercise Capacity and Risk Profile in Coronary Artery Disease|
|Actual Study Start Date :||December 20, 2016|
|Actual Primary Completion Date :||July 1, 2017|
|Actual Study Completion Date :||September 15, 2017|
Coronary Artery Disease (CAD) patients
Patients with proven coronary artery disease, who underwent the full cardiac revalidation program at Jessa Hospital from 10-1-2013 till 12-9-2016.
Other: Training intensity (workload) during ergospirometry
The reached workload (W) during each training is noted during 12 weeks of rehabilitation. The relative intensity is expressed as a percentage of VT1 and VT2.
- exercise capacity [ Time Frame: up to week 12 ]The primary endpoint is the relationship between the actual training load (W) and exercise capacity (VO2max) obtained at the end of the rehabilitation.
- cardiovascular risk profile [ Time Frame: up to week 12 ]The secondary endpoint is the relationship between relative training load and the cardiovascular risk factors.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03034980
|Hasselt, Belgium, 3500|
|Principal Investigator:||Kaatje Goetschalckx, MD||Catholic University Leuven, Belgium|