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Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels

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ClinicalTrials.gov Identifier: NCT03034824
Recruitment Status : Completed
First Posted : January 27, 2017
Last Update Posted : February 24, 2017
Sponsor:
Information provided by (Responsible Party):
Ahmet Cemil Talmac, Yuzuncu Yıl University

Brief Summary:
The aim of our study is to determine the interleukin-1βeta (IL-1β), interleukin-8 (IL-8) and tumor necrosis factor-αlfa (Tnf-α) levels in gingival crevicular fluid (GCF) and clinical periodontal parameters following the treatment with Erbium,Chromium:Yttrium-Scandium-Gallium-Garnet (Er,Cr:YSGG) and diode lasers in adjunct to scaling and root planing (SRP) in patients with generalized aggressive periodontitis (GAgP). Twenty-six patients with GAgP (n=26) were enrolled in the study. The study was designed as a "split-mouth" study. In each patient, three quadrants were randomly determined as SRP-control, SRP+Er,Cr:YSGG and SRP+Diode laser. Clinical periodontal measurements were recorded at the baseline and third month after the treatment. Cytokines levels in GCF were determined by enzyme-linked immunosorbent assay (ELISA).

Condition or disease Intervention/treatment Phase
Aggressive Periodontitis Procedure: SRP+940±15 nm diode laser Procedure: SRP+Er,Cr:YSGG laser Procedure: Scaling and root planing (SRP)-Control Not Applicable

  Show Detailed Description

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 26 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Comparison Of Er,Cr:YSGG and Diode Laser on the Periodontal Parameters and Cytokines Levels in Patients With Generalized Aggressive Periodontitis
Study Start Date : January 2014
Actual Primary Completion Date : September 2014
Actual Study Completion Date : August 2015

Arm Intervention/treatment
Experimental: Scaling and root planing (SRP)-Control
Only non-surgical initial periodontal treatment (scaling and root planing)
Procedure: Scaling and root planing (SRP)-Control
Only Non-surgical periodontal treatment

Experimental: SRP+940±15 nm diode laser
In addition to non-surgical initial periodontal treatment (scaling and root planing), individuals received 940±15 nm Diode laser
Procedure: SRP+940±15 nm diode laser
In addition to Non-surgical periodontal treatment, the individuals diagnosed with Generalized Aggressive Periodontitis were applied the 940±15 nm diode laser.

Experimental: SRP+Er,Cr:YSGG laser
In addition to non-surgical initial periodontal treatment (scaling and root planing), individuals received Er,Cr:YSGG laser
Procedure: SRP+Er,Cr:YSGG laser
In addition to Non-surgical periodontal treatment, the individuals diagnosed with Generalized Aggressive Periodontitis were applied the Er,Cr:YSGG laser.




Primary Outcome Measures :
  1. Periodontal Clinical Indices [ Time Frame: 1 year ]
    Bleeding on probing

  2. Periodontal Clinical Indices [ Time Frame: 1 year ]
    Plaque index

  3. Periodontal Clinical Indices [ Time Frame: 1 year ]
    Gingival index

  4. Periodontal Clinical Indices [ Time Frame: 1 year ]
    Probing pocket depth

  5. Periodontal Clinical Indices [ Time Frame: 1 year ]
    Clinical attachment level


Secondary Outcome Measures :
  1. Cytokines levels in gingival crevicular fluids [ Time Frame: 1 year ]
    Interleukin-1β

  2. Cytokines levels in gingival crevicular fluids [ Time Frame: 1 year ]
    Interleukin-8

  3. Cytokines levels in gingival crevicular fluids [ Time Frame: 1 year ]
    Tumor necrosis factor-α



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Ages Eligible for Study:   20 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • No systemic diseases
  • Not used antibiotics or any other medication affecting the immune system in the previous six months
  • Non-smokers
  • Have at least 16 teeth in their mouth
  • Have not received any periodontal treatment in the previous 6 months

Exclusion Criteria:

  • Under 18 age
  • Pregnant women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03034824


Sponsors and Collaborators
Yuzuncu Yıl University
Investigators
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Principal Investigator: Ahmet C Talmac, PhD Researcher

Publications of Results:
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Responsible Party: Ahmet Cemil Talmac, PhD, Dr. Dt., Yuzuncu Yıl University
ClinicalTrials.gov Identifier: NCT03034824     History of Changes
Other Study ID Numbers: JOP-16-0797
First Posted: January 27, 2017    Key Record Dates
Last Update Posted: February 24, 2017
Last Verified: February 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Ahmet Cemil Talmac, Yuzuncu Yıl University:
diode laser
Er,Cr:YSGG laser
Aggressive Periodontitis
Clinical periodontal parameters
Gingival crevicular fluid cytokines levels

Additional relevant MeSH terms:
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Periodontitis
Aggression
Aggressive Periodontitis
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases
Behavioral Symptoms