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The Effect of Tracheal Intubation on AC and DC Components of a Photoplethysmograph

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ClinicalTrials.gov Identifier: NCT03032939
Recruitment Status : Completed
First Posted : January 26, 2017
Last Update Posted : January 26, 2017
Sponsor:
Information provided by (Responsible Party):
Pekka Talke, University of California, San Francisco

Brief Summary:
Intraoperative stress responses (vasoconstriction and changes in heart rate) and postoperative pain can be monitored using photoplethysmography (PPG). PPG measures changes in tissue volume noninvasively. Therefore it can measure acute changes in arterial diameter (vasoconstriction). PPG signal has two components, AC and DC. Effects of noxious stimuli-induced stress responses (vasoconstriction) have not been studied on the DC component of PPG. The aim of this study was to investigate the effect of a known noxious stimulus (endotracheal intubation) on both the AC and DC components of PPG.

Condition or disease Intervention/treatment
Anesthesia Intubation Complication Procedure: endotracheal intubation

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Study Type : Observational
Actual Enrollment : 35 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Effect of Tracheal Intubation Induced Autonomic Response on Photoplethysmography
Actual Study Start Date : December 18, 2007
Actual Primary Completion Date : January 30, 2012
Actual Study Completion Date : January 30, 2015

Intervention Details:
  • Procedure: endotracheal intubation
    standard endotracheal intubation of surgical patients after induction of anesthesia


Primary Outcome Measures :
  1. Photoplethysmography [ Time Frame: within 60 seconds of intubation ]
    changes in AC and DC components of photoplethysmography


Secondary Outcome Measures :
  1. Pulse rate [ Time Frame: within 60 seconds of intubation ]
    Pulse rate from photoplethysmograph



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Elective, healthy surgical patients over 18 yrs of age
Criteria

Inclusion Criteria:

  • Elective surgery
  • General endotracheal anesthesia
  • Over 18 years of age
  • Healthy

Exclusion Criteria:

  • Vascular disease
  • Liver or kidney disease
  • Overweight

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03032939


Sponsors and Collaborators
University of California, San Francisco
Investigators
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Principal Investigator: Pekka O Talke, MD University of California, San Francisco
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Pekka Talke, Professor of Anesthesia, University of California, San Francisco
ClinicalTrials.gov Identifier: NCT03032939    
Other Study ID Numbers: PT071
First Posted: January 26, 2017    Key Record Dates
Last Update Posted: January 26, 2017
Last Verified: January 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: only a unique study number such as, IP01, that is unrelated to any patient identifiers will be used

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No