Atorvastatin as an Adjunct to DFDBA in Intrabony Defects
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|ClinicalTrials.gov Identifier: NCT03009097|
Recruitment Status : Completed
First Posted : January 4, 2017
Last Update Posted : January 4, 2017
Periodontitis is a major oral health problem which leads to the progressive destruction of periodontal ligament and alveolar bone with pocket formation, recession or both. The ultimate goal of periodontal therapy is to regenerate the lost periodontal tissue. The most common form of regenerative periodontal therapy is the use of bone grafts which stimulate bone formation by the processes of osteoinduction and osteoconduction.
Statins are a group of lipid lowering drugs which inhibit bone resorption by inhibition of the enzyme HMG-CoA reductase. They also stimulate new bone formation by local stimulation of BMP-2, a major bone growth regulatory factor. They also have anti-inflammatory and anti oxidant properties.
Very few studies exist evaluating the beneficiary effects of grafts if combined with the statins which might enhance the regeneration by bone grafts.
Hence, the present study was carried out in an attempt to comparatively evaluate clinically and radiologically, the efficacy of atorvastatin gel as an adjunct to allograft in the treatment of intrabony defects.
|Condition or disease||Intervention/treatment||Phase|
|Chronic Periaortitis Intrabony Periodontal Defect||Biological: DFDBA Drug: DFDBA with atorvastatin||Phase 4|
A total of 26 intrabony defects in patients with chronic periodontitis as diagnosed by radiographs, were selected for the study after taking an informed consent. The selected sites were randomized in 2 treatment groups.
Group I - sites were treated with allograft (DFDBA) Group II - sites were treated with allograft (DFDBA) in combination with Atorvastatin gel.
Clinical parameters like probing depth and clinical attachment level and radiological assessment of intrabony defect fill were done at baseline and 3 and 6 months postoperatively.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||26 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||"Comparative Evaluation Of The Efficacy Of Atorvastatin Gel As An Adjunct To Allografts In The Treatment Of Intrabony Defects" - A Clinico Radiological Study|
|Study Start Date :||April 2013|
|Actual Primary Completion Date :||August 2014|
|Actual Study Completion Date :||August 2014|
Active Comparator: DFDBA
13 intrabony defects in chronic periodontitis patients were treated with DFDBA
13 intrabony defects in chronic periodontitis patients were treated with allograft (DFDBA)
Other Name: Allograft
Active Comparator: DFDBA with Atorvastatin
13 intrabony defects in chronic periodontitis patients were treated with DFDBA in combination with Atorvastatin gel.
Drug: DFDBA with atorvastatin
13 intrabony defects in chronic periodontitis patients were treated with allograft (DFDBA) in combination with atorvastatin gel
Other Name: atorvastatin gel
- bone fill in mm was measured by taking radiographs [ Time Frame: 6 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03009097
|Principal Investigator:||Etika Rathi, MDS||Kamineni Institute of Dental Sciences|