Study of Methotrexate Given to Juvenile Idiopathic Arthritis Patients Based on Pharmacogenomics and Pharmacometrics
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03006991|
Recruitment Status : Recruiting
First Posted : December 30, 2016
Last Update Posted : December 30, 2016
|Condition or disease||Intervention/treatment|
|Juvenile Idiopathic Arthritis||Other: therapeutic drug monitoring|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Individual Study of Methotrexate Based on Pharmacogenomics and Pharmacometrics|
|Study Start Date :||November 2016|
|Estimated Primary Completion Date :||December 2020|
|Estimated Study Completion Date :||December 2023|
using therapeutic drug monitoring to adjust the dose of methotrexate. patients can reach effective outcome.
Other: therapeutic drug monitoring
dose of methotrexate can be adjusted by therapeutic drug monitoring.
patients can not reach effective outcome.
- Genotypes as measured by polymerase chain reaction-restriction fragment length polymorphism [ Time Frame: 3 months ]genotype are collected from hospital system.
- Concentration as measured by liquid chromatography mass spectrometry [ Time Frame: 3 months ]concentration of methotrexate are collected from hospital system
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03006991
|Contact: Xiaolan Mo, master||18820095289 ext +email@example.com|
|Contact: Ping Zeng, master||18198915521 ext +firstname.lastname@example.org|
|Guangzhou Women and Children's Medical Center||Recruiting|
|Guandong, Guangdong, China, 510000|
|Contact: Huasong Zeng, Doctor 18902268736 ext +86 email@example.com|
|Contact: Hongwei Li, Master 18038767213 ext +86 firstname.lastname@example.org|
|Principal Investigator:||Xiaolan Mo, master||Guangzhou Women and Children's Medical Center|